SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 TRP A 269
GLU A 205
TYR A 209
 None
 1.05A 2a3aA-2xlyA:
undetectable		 2a3aA-2xlyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 ASP A 182
VAL A 203
PRO A 197
 None
 0.80A 2avvA-2xlyA:
undetectable		 2avvA-2xlyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 7 THR A  91
LEU A 123
VAL A 164
ASP A  96
 None
 1.04A 2cppA-2xlyA:
undetectable		 2cppA-2xlyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 7 VAL A 216
LEU A 192
PHE A 186
HIS A 190
 None
 1.06A 2f78A-2xlyA:
undetectable		 2f78A-2xlyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		5 / 12 VAL A 266
LEU A 235
ARG A  66
ALA A  50
PHE A  68
 None
 1.20A 2jj8C-2xlyA:
undetectable		 2jj8C-2xlyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 THR A 219
ASP A 111
SER A 109
 None
 0.65A 2nxeA-2xlyA:
undetectable		 2nxeA-2xlyA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 THR A 219
ASP A 111
SER A 109
 None
 0.63A 2nxeB-2xlyA:
undetectable		 2nxeB-2xlyA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 THR A  51
ASP A 260
GLU A 290
 None
 0.83A 3qowA-2xlyA:
undetectable		 3qowA-2xlyA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		5 / 11 MET A 210
GLY A 301
GLY A 304
ILE A 134
LEU A 135
 None
 1.13A 4kt0A-2xlyA:
undetectable
4kt0J-2xlyA:
undetectable		 4kt0A-2xlyA:
19.36
4kt0J-2xlyA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 8 THR A  91
LEU A 123
VAL A 164
ASP A  96
 None
 1.03A 4l4dA-2xlyA:
undetectable		 4l4dA-2xlyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		5 / 12 TYR A 174
HIS A 190
PHE A 232
ASP A 276
GLY A 272
 None
 1.25A 4qa2B-2xlyA:
undetectable		 4qa2B-2xlyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 5 ALA A  47
THR A 285
THR A  51
TYR A 284
 None
 1.50A 4w5oA-2xlyA:
0.0		 4w5oA-2xlyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		3 / 3 THR A  51
ASP A 260
GLU A 290
 None
 0.79A 5fa8A-2xlyA:
undetectable		 5fa8A-2xlyA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 7 GLY A 110
SER A 109
PHE A  68
LEU A  52
 None
 0.82A 5izfA-2xlyA:
undetectable		 5izfA-2xlyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 7 VAL A 173
ALA A 162
LEU A 220
LEU A 222
 None
 0.59A 5jq7A-2xlyA:
undetectable		 5jq7A-2xlyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		4 / 6 PHE A  10
GLY A 286
THR A 285
ASN A 287
 None
 0.96A 5x24A-2xlyA:
undetectable		 5x24A-2xlyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		5 / 10 VAL A 173
ALA A 162
LEU A 220
LEU A 222
LEU A 135
 None
 0.95A 6f5uA-2xlyA:
undetectable
6f5uB-2xlyA:
undetectable		 6f5uA-2xlyA:
15.14
6f5uB-2xlyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2xly CLOQ
(Streptomyces
roseochromogenus) 		5 / 10 VAL A 173
ALA A 162
LEU A 220
LEU A 222
LEU A 135
 None
 0.97A 6f6nA-2xlyA:
undetectable
6f6nB-2xlyA:
undetectable		 6f6nA-2xlyA:
15.14
6f6nB-2xlyA:
13.00