SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2xme CTP-INOSITOL-1-PHOSP
HATE
CYTIDYLYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 9 ILE A 135
ILE A 112
GLY A 131
ALA A 128
THR A 114
 None
 1.31A 2dtjA-2xmeA:
undetectable
2dtjB-2xmeA:
undetectable		 2dtjA-2xmeA:
22.76
2dtjB-2xmeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2xme CTP-INOSITOL-1-PHOSP
HATE
CYTIDYLYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 7 ILE A  63
PRO A  38
ILE A  73
LEU A  77
ILE A  48
 None
 1.36A 2q83A-2xmeA:
undetectable		 2q83A-2xmeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2xme CTP-INOSITOL-1-PHOSP
HATE
CYTIDYLYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 174
ASP A 117
ASP A 172
ILE A 161
GLY A 162
 None
 0.97A 3eeyJ-2xmeA:
3.5		 3eeyJ-2xmeA:
23.35