SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 101
HIS A 135
HIS A  49
 FE  A 556 (-2.8A)
PO4  A1444 (-3.8A)
MN  A 555 ( 3.4A)
 0.61A 1oe1A-2xmoA:
undetectable		 1oe1A-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 101
HIS A 135
HIS A  49
 FE  A 556 (-2.8A)
PO4  A1444 (-3.8A)
MN  A 555 ( 3.4A)
 0.60A 1oe3A-2xmoA:
undetectable		 1oe3A-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLY A 106
GLU A 107
ASP A 136
 None
 0.68A 2b25B-2xmoA:
undetectable		 2b25B-2xmoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A  47
HIS A 243
SER A 279
HIS A 249
 MN  A 555 (-3.2A)
FE  A 556 (-3.4A)
None
None
 1.11A 2q0iA-2xmoA:
undetectable		 2q0iA-2xmoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  98
LEU A 114
GLU A 107
THR A 155
ILE A 164
 None
 1.10A 2vn0A-2xmoA:
undetectable		 2vn0A-2xmoA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 101
HIS A 135
HIS A  49
 FE  A 556 (-2.8A)
PO4  A1444 (-3.8A)
MN  A 555 ( 3.4A)
 0.61A 2xxgA-2xmoA:
undetectable		 2xxgA-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 101
HIS A 135
HIS A  49
 FE  A 556 (-2.8A)
PO4  A1444 (-3.8A)
MN  A 555 ( 3.4A)
 0.61A 2xxgC-2xmoA:
undetectable		 2xxgC-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  98
LEU A 102
THR A 126
VAL A  88
LEU A  85
 None
 1.18A 3a51C-2xmoA:
1.0		 3a51C-2xmoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLY A 169
PRO A 187
LEU A 193
 None
 0.63A 3hcpB-2xmoA:
undetectable		 3hcpB-2xmoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 HIS A 244
HIS A 243
HIS A 281
 None
FE  A 556 (-3.4A)
FE  A 556 ( 3.3A)
 0.63A 3mihA-2xmoA:
undetectable		 3mihA-2xmoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A 242
ASP A 197
ASP A 177
SER A 180
 None
 0.97A 3qj7A-2xmoA:
undetectable
3qj7D-2xmoA:
undetectable		 3qj7A-2xmoA:
20.85
3qj7D-2xmoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 HIS A 243
GLY A 133
VAL A  48
ASP A  47
GLY A 214
 FE  A 556 (-3.4A)
None
None
MN  A 555 (-3.2A)
None
 1.01A 3sudD-2xmoA:
undetectable		 3sudD-2xmoA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 HIS A 243
GLY A 133
VAL A  48
ASP A  47
GLY A 214
 FE  A 556 (-3.4A)
None
None
MN  A 555 (-3.2A)
None
 0.98A 3sueC-2xmoA:
undetectable		 3sueC-2xmoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 HIS A 243
GLY A 133
VAL A  48
ASP A  47
GLY A 214
 FE  A 556 (-3.4A)
None
None
MN  A 555 (-3.2A)
None
 0.98A 3sufD-2xmoA:
undetectable		 3sufD-2xmoA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A 194
SER A 182
TRP A 223
ASP A 222
 None
 1.10A 4drjB-2xmoA:
2.4		 4drjB-2xmoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 10 PHE A 276
THR A 303
SER A 279
ASP A  47
GLY A 314
 None
None
None
MN  A 555 (-3.2A)
None
 1.33A 4qb9A-2xmoA:
1.8		 4qb9A-2xmoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 10 PHE A 276
THR A 303
SER A 279
ASP A  47
GLY A 314
 None
None
None
MN  A 555 (-3.2A)
None
 1.47A 4qb9C-2xmoA:
1.0		 4qb9C-2xmoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 12 PHE A 276
THR A 303
SER A 279
ASP A  47
GLY A 314
 None
None
None
MN  A 555 (-3.2A)
None
 1.46A 4qb9E-2xmoA:
undetectable		 4qb9E-2xmoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 PHE A 325
ILE A 239
ASP A 300
 None
 0.75A 5cswA-2xmoA:
undetectable		 5cswA-2xmoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 438
ASN A 315
PHE A 400
 None
 0.75A 5jglB-2xmoA:
undetectable		 5jglB-2xmoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 6 ASP A 101
ASP A  47
HIS A  49
HIS A 283
HIS A 243
 FE  A 556 (-2.8A)
MN  A 555 (-3.2A)
MN  A 555 ( 3.4A)
MN  A 555 ( 3.4A)
FE  A 556 (-3.4A)
 1.08A 5ncdB-2xmoA:
undetectable
5ncdC-2xmoA:
2.7		 5ncdB-2xmoA:
18.69
5ncdC-2xmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 4 ASP A 101
HIS A 243
HIS A 281
HIS A 135
 FE  A 556 (-2.8A)
FE  A 556 (-3.4A)
FE  A 556 ( 3.3A)
PO4  A1444 (-3.8A)
 1.46A 5ncdD-2xmoA:
2.7		 5ncdD-2xmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		5 / 6 ASP A 101
ASP A  47
HIS A  49
HIS A 283
HIS A 243
 FE  A 556 (-2.8A)
MN  A 555 (-3.2A)
MN  A 555 ( 3.4A)
MN  A 555 ( 3.4A)
FE  A 556 (-3.4A)
 1.08A 5nelA-2xmoA:
2.6
5nelD-2xmoA:
undetectable		 5nelA-2xmoA:
18.69
5nelD-2xmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP A 101
HIS A  49
HIS A 283
HIS A 243
 FE  A 556 (-2.8A)
MN  A 555 ( 3.4A)
MN  A 555 ( 3.4A)
FE  A 556 (-3.4A)
 0.99A 5nelB-2xmoA:
undetectable
5nelC-2xmoA:
undetectable		 5nelB-2xmoA:
18.69
5nelC-2xmoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 7 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.18A 5u6mA-2xmoA:
undetectable		 5u6mA-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 7 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.28A 5u6mB-2xmoA:
undetectable		 5u6mB-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.24A 5u6nA-2xmoA:
undetectable		 5u6nA-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 6 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.21A 5u6nB-2xmoA:
1.2		 5u6nB-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 THR A 103
HIS A 243
ASN A 134
PRO A 210
 None
FE  A 556 (-3.4A)
PO4  A1444 ( 2.6A)
None
 1.23A 5v4vA-2xmoA:
2.1		 5v4vA-2xmoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 THR A 103
HIS A 243
ASN A 134
PRO A 210
 None
FE  A 556 (-3.4A)
PO4  A1444 ( 2.6A)
None
 1.23A 5v4vB-2xmoA:
undetectable		 5v4vB-2xmoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 135
ASP A 136
HIS A  49
ASN A 104
 PO4  A1444 (-3.8A)
None
MN  A 555 ( 3.4A)
None
 1.05A 5zj8A-2xmoA:
undetectable		 5zj8A-2xmoA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		3 / 3 TYR A 165
PRO A 132
LEU A 181
 None
 0.61A 6beoA-2xmoA:
undetectable		 6beoA-2xmoA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A 127
VAL A 128
PRO A 187
THR A  45
 None
 1.46A 6cduA-2xmoA:
undetectable
6cduB-2xmoA:
undetectable		 6cduA-2xmoA:
21.17
6cduB-2xmoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2xmo LMO2642 PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A 127
VAL A 128
PRO A 187
THR A  45
 None
 1.44A 6cduI-2xmoA:
undetectable
6cduJ-2xmoA:
undetectable		 6cduI-2xmoA:
21.17
6cduJ-2xmoA:
21.17