SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		3 / 3 THR A 267
THR A 269
PRO A 266
 None
 0.80A 1dscC-2xmrA:
undetectable		 1dscC-2xmrA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		3 / 3 ASP A 158
ASP A 228
ASP A 255
 None
 0.63A 1eizA-2xmrA:
undetectable		 1eizA-2xmrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		3 / 3 ASP A 158
ASP A 228
ASP A 255
 None
 0.61A 1ej0A-2xmrA:
2.5		 1ej0A-2xmrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 7 LEU A  52
ALA A  50
VAL A  82
VAL A  40
TYR A 120
 None
 1.48A 1epbA-2xmrA:
undetectable		 1epbA-2xmrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 9 ASN A 160
LEU A 229
ALA A 139
LEU A 143
LEU A 239
 None
 1.33A 1hwiA-2xmrA:
undetectable		 1hwiA-2xmrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 GLY A 278
SER A 277
GLU A 192
ILE A 200
LEU A 199
 None
 1.08A 1kyvA-2xmrA:
undetectable
1kyvE-2xmrA:
undetectable		 1kyvA-2xmrA:
20.76
1kyvE-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.10A 1kyvA-2xmrA:
undetectable
1kyvB-2xmrA:
undetectable		 1kyvA-2xmrA:
20.76
1kyvB-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.07A 1kyvB-2xmrA:
undetectable
1kyvC-2xmrA:
undetectable		 1kyvB-2xmrA:
20.76
1kyvC-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.08A 1kyvC-2xmrA:
undetectable
1kyvD-2xmrA:
undetectable		 1kyvC-2xmrA:
20.76
1kyvD-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.09A 1kyvD-2xmrA:
undetectable
1kyvE-2xmrA:
undetectable		 1kyvD-2xmrA:
20.76
1kyvE-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.11A 2a58A-2xmrA:
undetectable
2a58B-2xmrA:
undetectable		 2a58A-2xmrA:
20.76
2a58B-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.11A 2a58B-2xmrA:
undetectable
2a58C-2xmrA:
undetectable		 2a58B-2xmrA:
20.76
2a58C-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.11A 2a58D-2xmrA:
undetectable
2a58E-2xmrA:
undetectable		 2a58D-2xmrA:
20.76
2a58E-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 4 ASP A 158
ASP A 228
ASP A 255
GLY A 163
 None
 1.21A 2igtC-2xmrA:
2.0		 2igtC-2xmrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 5 ALA A 251
ASP A 158
ASP A 228
ASP A 255
 None
 1.11A 2nyuB-2xmrA:
undetectable		 2nyuB-2xmrA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 7 TYR A  41
GLN A  66
PHE A  69
ARG A  83
HIS A  85
 ACT  A1306 ( 3.9A)
None
None
ACT  A1306 (-3.7A)
ACT  A1306 (-3.9A)
 0.44A 2qmqA-2xmrA:
46.5		 2qmqA-2xmrA:
91.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 7 TYR A  41
GLN A  70
PHE A  69
ARG A  83
HIS A  85
 ACT  A1306 ( 3.9A)
None
None
ACT  A1306 (-3.7A)
ACT  A1306 (-3.9A)
 0.73A 2qmqA-2xmrA:
46.5		 2qmqA-2xmrA:
91.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 7 TYR A  41
TYR A  61
GLN A  70
ARG A  83
HIS A  85
 ACT  A1306 ( 3.9A)
None
None
ACT  A1306 (-3.7A)
ACT  A1306 (-3.9A)
 1.06A 2qmqA-2xmrA:
46.5		 2qmqA-2xmrA:
91.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 10 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.03A 3dcwA-2xmrA:
undetectable		 3dcwA-2xmrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 10 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.05A 3dd0A-2xmrA:
undetectable		 3dd0A-2xmrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		3 / 3 ASP A 158
ASP A 228
ASP A 255
 None
 0.68A 3douA-2xmrA:
3.3		 3douA-2xmrA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 VAL A 129
ILE A 155
VAL A 153
LEU A 289
THR A 290
 None
 0.91A 3fw3A-2xmrA:
undetectable		 3fw3A-2xmrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.07A 3kwaA-2xmrA:
undetectable		 3kwaA-2xmrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.06A 4e47A-2xmrA:
undetectable		 4e47A-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.04A 4e47B-2xmrA:
undetectable		 4e47B-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.11A 4e47C-2xmrA:
undetectable		 4e47C-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.04A 4jdsA-2xmrA:
undetectable		 4jdsA-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.05A 4jdsB-2xmrA:
undetectable		 4jdsB-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.12A 4jdsC-2xmrA:
undetectable		 4jdsC-2xmrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.09A 4k0zA-2xmrA:
undetectable		 4k0zA-2xmrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 11 ILE A 155
GLY A 248
GLU A 254
GLY A 185
ASN A 156
 None
 1.08A 5ayfA-2xmrA:
undetectable		 5ayfA-2xmrA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 PHE A  81
ILE A  78
LEU A  52
PHE A  69
THR A  53
 None
 1.14A 5byjA-2xmrA:
undetectable		 5byjA-2xmrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 LEU A  52
TYR A  61
TYR A 219
TYR A 141
LEU A 138
 None
 1.29A 5czyA-2xmrA:
undetectable		 5czyA-2xmrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 5 VAL A 131
VAL A 129
GLY A 128
PHE A  65
 None
 1.10A 5d4nA-2xmrA:
undetectable
5d4nC-2xmrA:
undetectable		 5d4nA-2xmrA:
18.12
5d4nC-2xmrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 8 HIS A 253
GLY A 132
VAL A 257
HIS A 186
 None
 0.75A 5f8yA-2xmrA:
undetectable		 5f8yA-2xmrA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 8 HIS A 253
GLY A 132
VAL A 257
HIS A 186
 None
 0.77A 5f8yB-2xmrA:
undetectable		 5f8yB-2xmrA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		4 / 6 ARG A  48
ARG A  83
ALA A  50
PRO A  49
 None
ACT  A1306 (-3.7A)
None
None
 1.22A 5odqA-2xmrA:
2.4		 5odqA-2xmrA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 ILE A  51
PHE A 296
GLY A 151
LEU A 154
MET A 244
 None
 1.20A 5v5zA-2xmrA:
undetectable		 5v5zA-2xmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.05A 6bccA-2xmrA:
undetectable		 6bccA-2xmrA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2xmr PROTEIN NDRG2
(Homo
sapiens) 		5 / 12 GLU A 291
GLY A 287
TYR A 295
PRO A 242
PRO A 281
 None
 1.38A 6gngA-2xmrA:
5.8		 6gngA-2xmrA:
17.32