SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		5 / 10 GLY A  22
PHE A  23
SER A  89
MET A  90
HIS A 243
 None
 0.86A 1a8uA-2xmzA:
28.1		 1a8uA-2xmzA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 7 TYR A  88
GLN A 159
SER A 158
GLN A 173
 None
 1.41A 1eiiA-2xmzA:
undetectable		 1eiiA-2xmzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 7 LEU A  20
ILE A 222
THR A 114
TRP A 198
 None
 1.29A 1kglA-2xmzA:
undetectable		 1kglA-2xmzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A  22
TYR A  30
SER A  89
PHE A 156
HIS A 243
 None
 1.41A 1maaC-2xmzA:
2.0		 1maaC-2xmzA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 8 PHE A  19
TYR A  30
LEU A 211
LEU A 209
 None
 0.99A 2bfpC-2xmzA:
4.2		 2bfpC-2xmzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 7 THR A  84
PHE A  19
PHE A 253
ILE A 257
 None
 0.66A 2y7wC-2xmzA:
undetectable		 2y7wC-2xmzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		5 / 10 TYR A  88
PHE A  19
ILE A 110
ALA A  95
PHE A  37
 None
 1.27A 3ay0A-2xmzA:
2.1		 3ay0A-2xmzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		3 / 3 PHE A  19
GLN A 173
PHE A  37
 None
 0.71A 3rv5A-2xmzA:
undetectable		 3rv5A-2xmzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		3 / 3 VAL A  43
ALA A   9
PHE A   6
 None
 0.74A 4olbA-2xmzA:
2.7		 4olbA-2xmzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		3 / 3 VAL A  43
ALA A   9
PHE A   6
 None
 0.82A 4w5nA-2xmzA:
2.2		 4w5nA-2xmzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 4 LEU A 209
LEU A 261
GLY A 259
GLU A 263
 None
 1.08A 5hhjA-2xmzA:
undetectable		 5hhjA-2xmzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 6 LEU A  20
ILE A 222
THR A 114
TRP A 198
 None
 1.37A 5ljeA-2xmzA:
undetectable		 5ljeA-2xmzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		5 / 10 ARG A 187
ALA A 135
LEU A 186
GLY A 190
LEU A 160
 None
 1.25A 5oy01-2xmzA:
undetectable
5oy07-2xmzA:
undetectable		 5oy01-2xmzA:
15.85
5oy07-2xmzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 6 PHE A  23
ARG A 174
ALA A 185
GLN A 173
 None
 0.99A 6b89B-2xmzA:
undetectable		 6b89B-2xmzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY
(Staphylococcus
aureus) 		4 / 6 GLY A  52
ASP A  47
SER A  27
ARG A  28
 None
 1.14A 6dwdA-2xmzA:
undetectable
6dwdC-2xmzA:
undetectable		 6dwdA-2xmzA:
19.89
6dwdC-2xmzA:
19.89