SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 10 PHE A  48
LEU A  57
PHE A  37
THR A 299
LEU A 300
 None
 1.09A 1a8uA-2xn6A:
undetectable		 1a8uA-2xn6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 10 PHE A  48
LEU A  57
PHE A  37
THR A 299
LEU A 300
 None
 1.07A 1a8uB-2xn6A:
undetectable		 1a8uB-2xn6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.86A 1i3wE-2xn6A:
undetectable		 1i3wE-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.85A 1i3wG-2xn6A:
undetectable		 1i3wG-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.84A 1i3wH-2xn6A:
undetectable		 1i3wH-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.81A 1mnvD-2xn6A:
undetectable		 1mnvD-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 8 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.12A 1os6A-2xn6A:
undetectable		 1os6A-2xn6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.84A 1ovfB-2xn6A:
undetectable		 1ovfB-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.83A 1unjF-2xn6A:
undetectable		 1unjF-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.85A 1unjL-2xn6A:
undetectable		 1unjL-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.85A 1unjL-2xn6A:
undetectable		 1unjL-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.85A 1unjR-2xn6A:
undetectable		 1unjR-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.83A 1unjR-2xn6A:
undetectable		 1unjR-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.84A 1unjW-2xn6A:
undetectable		 1unjW-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.85A 1unjX-2xn6A:
undetectable		 1unjX-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.83A 1unjX-2xn6A:
undetectable		 1unjX-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.87A 1unmE-2xn6A:
undetectable		 1unmE-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  41
THR A  38
PRO A  42
 EDO  A1363 ( 3.9A)
None
None
 0.83A 1unmE-2xn6A:
undetectable		 1unmE-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		3 / 3 THR A  38
PRO A  42
THR A  41
 None
None
EDO  A1363 ( 3.9A)
 0.85A 1unmF-2xn6A:
undetectable		 1unmF-2xn6A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 9 GLU A  71
LEU A 350
LEU A  57
ALA A  64
ALA A 308
 None
 1.17A 2bxcB-2xn6A:
undetectable		 2bxcB-2xn6A:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 11 ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
 0.43A 2ceoA-2xn6A:
41.3		 2ceoA-2xn6A:
86.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 11 ALA A  27
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.56A 2ceoA-2xn6A:
41.3		 2ceoA-2xn6A:
86.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 10 ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
 0.43A 2ceoB-2xn6A:
41.4		 2ceoB-2xn6A:
86.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 10 ALA A  27
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.56A 2ceoB-2xn6A:
41.4		 2ceoB-2xn6A:
86.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.02A 2dysC-2xn6A:
undetectable
2dysJ-2xn6A:
undetectable		 2dysC-2xn6A:
20.83
2dysJ-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 0.98A 2dysP-2xn6A:
undetectable
2dysW-2xn6A:
undetectable		 2dysP-2xn6A:
20.83
2dysW-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.07A 2einP-2xn6A:
undetectable
2einW-2xn6A:
undetectable		 2einP-2xn6A:
20.83
2einW-2xn6A:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 10 ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
 0.31A 2riwA-2xn6A:
54.1
2riwB-2xn6A:
undetectable		 2riwA-2xn6A:
97.97
2riwB-2xn6A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 VAL A  58
ILE A 110
LEU A  95
PHE A  92
SER A  49
 None
 1.11A 2w3vA-2xn6A:
undetectable		 2w3vA-2xn6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 11 SER A  49
SER A  52
ALA A 347
GLY A 346
ALA A 345
 None
 1.23A 2xh9A-2xn6A:
1.4		 2xh9A-2xn6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 10 SER A  49
SER A  52
ALA A 347
GLY A 346
ALA A 345
 None
 1.24A 2xh9B-2xn6A:
1.4		 2xh9B-2xn6A:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		6 / 8 GLN A 238
LEU A 246
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.18A 2xn3A-2xn6A:
53.6
2xn3B-2xn6A:
undetectable		 2xn3A-2xn6A:
99.42
2xn3B-2xn6A:
7.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		6 / 11 GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
 1.18A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		8 / 11 SER A  23
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
 0.95A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		10 / 11 SER A  23
SER A  24
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.48A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		10 / 11 SER A  23
SER A  24
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
LYS A 270
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
 0.75A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		6 / 11 SER A  24
GLN A 238
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
None
T44  A1370 (-4.0A)
None
 1.25A 2xn5A-2xn6A:
53.6		 2xn5A-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 10 ALA A  27
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.33A 2xn7A-2xn6A:
53.8
2xn7B-2xn6A:
undetectable		 2xn7A-2xn6A:
99.71
2xn7B-2xn6A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.03A 2zxwP-2xn6A:
undetectable
2zxwW-2xn6A:
undetectable		 2zxwP-2xn6A:
20.83
2zxwW-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 9 MET A 348
ALA A 329
LEU A 326
ILE A  72
LEU A  76
 None
 1.37A 3fl9D-2xn6A:
undetectable		 3fl9D-2xn6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 ILE A  46
ALA A 292
PHE A  37
SER A  52
ILE A  53
 None
EDO  A1363 (-3.3A)
None
None
None
 1.19A 3ia4D-2xn6A:
undetectable		 3ia4D-2xn6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 ALA A 308
LEU A 127
LEU A 324
PHE A 315
MET A 178
 None
 1.12A 3k2hA-2xn6A:
undetectable		 3k2hA-2xn6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 ALA A 308
LEU A 127
LEU A 324
PHE A 315
MET A 178
 None
 1.12A 3k2hB-2xn6A:
undetectable		 3k2hB-2xn6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 SER A 310
TYR A 309
ALA A 313
LEU A 301
 None
 1.16A 3rd0A-2xn6A:
undetectable		 3rd0A-2xn6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 8 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.11A 3selX-2xn6A:
undetectable		 3selX-2xn6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 4 GLY A  63
GLY A 317
THR A 319
LEU A 324
 None
 0.91A 3si7C-2xn6A:
undetectable
3si7D-2xn6A:
undetectable		 3si7C-2xn6A:
20.44
3si7D-2xn6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 ILE A 116
LYS A 125
PHE A 126
GLY A  63
 None
 1.12A 3sj0X-2xn6A:
undetectable		 3sj0X-2xn6A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 6 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.13A 3sj1X-2xn6A:
undetectable		 3sj1X-2xn6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 9 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.10A 3sj4X-2xn6A:
undetectable		 3sj4X-2xn6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 PHE A  92
ASN A  26
PHE A  29
ALA A  30
 None
 1.04A 3t3sB-2xn6A:
undetectable		 3t3sB-2xn6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 9 ILE A  46
ALA A 292
PHE A  37
SER A  52
ILE A  53
 None
EDO  A1363 (-3.3A)
None
None
None
 1.19A 3tq8A-2xn6A:
undetectable		 3tq8A-2xn6A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 7 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.14A 4hajA-2xn6A:
undetectable		 4hajA-2xn6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 7 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.10A 4hbfA-2xn6A:
undetectable		 4hbfA-2xn6A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 ILE A 116
LEU A 114
LYS A 125
GLY A  63
 None
 0.89A 4hc3A-2xn6A:
undetectable		 4hc3A-2xn6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.05A 4hc3A-2xn6A:
undetectable		 4hc3A-2xn6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 ARG A  36
ILE A  53
PHE A  29
LEU A  57
 None
 0.90A 4mmcA-2xn6A:
undetectable		 4mmcA-2xn6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 7 PHE A 249
LEU A 237
THR A 342
VAL A 285
 None
 0.75A 4wnvD-2xn6A:
undetectable		 4wnvD-2xn6A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 9 ALA A  27
GLN A 238
LEU A 246
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.35A 4x30A-2xn6A:
41.3		 4x30A-2xn6A:
88.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		6 / 10 GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
 T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
 1.22A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		7 / 10 SER A  23
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
 1.12A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		8 / 10 SER A  23
SER A  24
GLN A 238
SER A 266
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.91A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		8 / 10 SER A  24
GLN A 238
LEU A 246
LEU A 248
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.49A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		8 / 10 SER A  24
GLN A 238
LEU A 248
SER A 266
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 0.78A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 10 SER A  24
LEU A 269
TRP A 272
ASN A 273
LEU A 276
 T44  A1370 ( 4.7A)
T44  A1370 (-4.0A)
None
T44  A1370 ( 3.3A)
None
 1.18A 4yiaA-2xn6A:
54.1		 4yiaA-2xn6A:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 8 LEU A 114
PHE A 126
GLY A  63
LEU A 324
 None
 0.89A 5eseA-2xn6A:
undetectable		 5eseA-2xn6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 LEU A 300
LEU A 350
ALA A 329
ILE A  46
ILE A  53
 None
 1.17A 5h8tA-2xn6A:
undetectable		 5h8tA-2xn6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 5 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.06A 5iy5P-2xn6A:
undetectable
5iy5W-2xn6A:
undetectable		 5iy5P-2xn6A:
20.89
5iy5W-2xn6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 6 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.02A 5w97C-2xn6A:
undetectable
5w97J-2xn6A:
undetectable		 5w97C-2xn6A:
20.83
5w97J-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		5 / 12 ALA A  56
GLY A 111
GLY A  63
LEU A 324
LEU A 318
 None
 1.13A 5wwsA-2xn6A:
undetectable		 5wwsA-2xn6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 5 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.03A 5x1fC-2xn6A:
undetectable
5x1fJ-2xn6A:
undetectable		 5x1fC-2xn6A:
20.83
5x1fJ-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 5 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.13A 5xdxC-2xn6A:
undetectable
5xdxJ-2xn6A:
undetectable		 5xdxC-2xn6A:
20.89
5xdxJ-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens) 		4 / 5 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.11A 5xdxP-2xn6A:
undetectable
5xdxW-2xn6A:
undetectable		 5xdxP-2xn6A:
20.89
5xdxW-2xn6A:
11.11