SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J7X_A_ESTA1454_1 (ESTROGEN RECEPTOR BETA)	2xnf	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 (Homo sapiens)	5 / 12	LEU A 511 LEU A 525 LEU A 514 GLY A 462 LEU A 464	None	1.27A	2j7xA-2xnfA: undetectable	2j7xA-2xnfA: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KW4_A_TICA600_1 (CYTOCHROME P450 2B4)	2xnf	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 (Homo sapiens)	5 / 11	ILE A 526 PHE A 500 VAL A 431 VAL A 471 GLY A 524	None	0.90A	3kw4A-2xnfA: undetectable	3kw4A-2xnfA: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OWX_A_XRAA233_2 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	2xnf	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 (Homo sapiens)	4 / 5	VAL A 510 PHE A 473 PHE A 522 PHE A 475	None	1.07A	3owxB-2xnfA: undetectable	3owxB-2xnfA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J26_A_ESTA600_1 (ESTROGEN RECEPTOR BETA)	2xnf	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 (Homo sapiens)	5 / 12	LEU A 511 LEU A 525 LEU A 514 GLY A 462 LEU A 464	None	1.30A	4j26A-2xnfA: undetectable	4j26A-2xnfA: 19.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J7X_A_ESTA1454_1","ESTROGEN RECEPTOR BETA","2xnf","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25","Homo sapiens",5,"LEU A 511;LEU A 525;LEU A 514;GLY A 462;LEU A 464","None","1.27A","2j7xA-2xnfA:undetectable","2j7xA-2xnfA:20.33"],["3KW4_A_TICA600_1","CYTOCHROME P450 2B4","2xnf","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25","Homo sapiens",5,"ILE A 526;PHE A 500;VAL A 431;VAL A 471;GLY A 524","None","0.90A","3kw4A-2xnfA:undetectable","3kw4A-2xnfA:15.72"],["3OWX_A_XRAA233_2","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","2xnf","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25","Homo sapiens",4,"VAL A 510;PHE A 473;PHE A 522;PHE A 475","None","1.07A","3owxB-2xnfA:undetectable","3owxB-2xnfA:20.76"],["4J26_A_ESTA600_1","ESTROGEN RECEPTOR BETA","2xnf","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25","Homo sapiens",5,"LEU A 511;LEU A 525;LEU A 514;GLY A 462;LEU A 464","None","1.30A","4j26A-2xnfA:undetectable","4j26A-2xnfA:19.35"]]