SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 8 ALA A 160
LEU A 146
GLU A 279
THR A 114
 None
 0.93A 1ie4B-2xnhA:
undetectable
1ie4D-2xnhA:
undetectable		 1ie4B-2xnhA:
17.56
1ie4D-2xnhA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A  53
GLY A  75
ASP A  54
PHE A  68
ILE A  50
 None
 1.27A 3k13C-2xnhA:
undetectable		 3k13C-2xnhA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO A  95
MET A 130
GLY A 132
SER A 107
PRO A 100
 None
IOD  A1294 ( 4.0A)
None
None
IOD  A1294 ( 4.5A)
 1.18A 3v8vA-2xnhA:
undetectable		 3v8vA-2xnhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 270
ASP A 269
ILE A 199
PHE A 267
 None
 1.04A 4acbC-2xnhA:
3.1		 4acbC-2xnhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A 240
LEU A 210
VAL A 262
THR A 222
TRP A 266
 None
 1.22A 4k0sA-2xnhA:
undetectable		 4k0sA-2xnhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 167
PRO A 169
TYR A 156
LEU A 201
GLY A 274
 None
IOD  A1299 ( 4.7A)
None
None
None
 1.32A 4l9qA-2xnhA:
undetectable		 4l9qA-2xnhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 207
ILE A 205
VAL A 218
THR A 222
 None
 0.73A 4xdtA-2xnhA:
undetectable		 4xdtA-2xnhA:
20.16