SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens) 		4 / 4 ASP A 591
LEU A 606
GLY A 605
ARG A 610
 None
 1.47A 2j2pD-2xocA:
0.0
2j2pE-2xocA:
0.0		 2j2pD-2xocA:
20.88
2j2pE-2xocA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens) 		3 / 3 CYH A 524
CYH A 532
HIS A 519
 ZN  A 993 ( 2.4A)
ZN  A 993 (-2.4A)
None
 0.77A 3dtuB-2xocA:
undetectable		 3dtuB-2xocA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens) 		3 / 3 CYH A 524
CYH A 532
HIS A 519
 ZN  A 993 ( 2.4A)
ZN  A 993 (-2.4A)
None
 0.77A 3dtuD-2xocA:
undetectable		 3dtuD-2xocA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens) 		3 / 3 ILE A 559
VAL A 629
ARG A 632
 None
 0.57A 3p73A-2xocA:
undetectable		 3p73A-2xocA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens) 		4 / 7 ARG A 504
VAL A 505
GLU A 498
ARG A 495
 None
 1.32A 4mv7A-2xocA:
undetectable		 4mv7A-2xocA:
17.47