SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  95
THR A 120
LEU A 124
GLY A 122
PHE A  67
 None
 1.34A 1d4fA-2xomA:
undetectable		 1d4fA-2xomA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 7 PHE A  35
PHE A  30
PHE A 160
VAL A  40
 None
 0.92A 1lh6A-2xomA:
undetectable		 1lh6A-2xomA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 4 GLY A 155
VAL A 100
TRP A  68
GLY A 152
 None
None
GAL  A1166 ( 4.3A)
None
 1.42A 1ng8A-2xomA:
undetectable		 1ng8A-2xomA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 4 GLY A 155
VAL A 100
TRP A  68
GLY A 152
 None
None
GAL  A1166 ( 4.3A)
None
 1.42A 1ng8B-2xomA:
undetectable		 1ng8B-2xomA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 5 PHE A  35
PHE A  30
PHE A 160
VAL A  40
 None
 0.93A 2lh6A-2xomA:
undetectable		 2lh6A-2xomA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		5 / 12 HIS A  95
THR A 120
LEU A 124
GLY A 122
PHE A  67
 None
 1.37A 3n58A-2xomA:
undetectable		 3n58A-2xomA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1491_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 4 GLY A 122
TRP A 126
GLU A 125
THR A 121
 None
 1.38A 4at0A-2xomA:
0.0		 4at0A-2xomA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		5 / 12 PHE A  92
ILE A 157
GLY A  29
PHE A 160
ALA A  52
 None
None
CA  A1169 (-3.7A)
None
None
 1.20A 4eb4A-2xomA:
undetectable		 4eb4A-2xomA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		5 / 12 PHE A  92
ILE A 157
GLY A  29
PHE A 160
ALA A  52
 None
None
CA  A1169 (-3.7A)
None
None
 1.21A 4eb4B-2xomA:
undetectable		 4eb4B-2xomA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 6 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.04A 4mi4A-2xomA:
undetectable		 4mi4A-2xomA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 7 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.03A 4mi4B-2xomA:
undetectable
4mi4C-2xomA:
undetectable		 4mi4B-2xomA:
24.04
4mi4C-2xomA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 8 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.01A 4mj8A-2xomA:
undetectable
4mj8C-2xomA:
undetectable		 4mj8A-2xomA:
23.56
4mj8C-2xomA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE
(Thermotoga
maritima) 		4 / 8 ASN A 133
GLU A 130
TYR A  88
GLU A 165
 None
 1.01A 4mj8B-2xomA:
undetectable
4mj8C-2xomA:
undetectable		 4mj8B-2xomA:
23.56
4mj8C-2xomA:
23.56