SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 5 PHE A 247
TYR A 217
LEU A 189
ASP A 246
 None
 1.34A 1dz6A-2xotA:
undetectable		 1dz6A-2xotA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 LEU A 139
PHE A 130
LEU A 160
MET A 157
ILE A 146
 None
 1.43A 1hrkB-2xotA:
undetectable		 1hrkB-2xotA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 11 LEU A 112
ASP A 156
ILE A 101
PRO A 108
VAL A 109
 None
 0.92A 1hxwB-2xotA:
undetectable		 1hxwB-2xotA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 11 LEU A 115
ASN A 168
ILE A 146
LEU A 125
PHE A 154
 None
 1.46A 1tw4A-2xotA:
undetectable		 1tw4A-2xotA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 6 LEU A 129
LEU A 165
LEU A 122
ILE A 170
 None
 0.86A 1z95A-2xotA:
undetectable		 1z95A-2xotA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 6 LEU A 165
LEU A 192
LEU A 177
LEU A 160
 None
 1.02A 2ab2A-2xotA:
undetectable		 2ab2A-2xotA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 LEU A 139
PHE A 130
LEU A 160
MET A 157
ILE A 146
 None
 1.29A 2pnjB-2xotA:
undetectable		 2pnjB-2xotA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 LEU A 117
LEU A 141
LEU A 165
LEU A 133
MET A 157
 None
 1.36A 3d90A-2xotA:
undetectable		 3d90A-2xotA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 TYR A 142
ASP A  67
SER A  90
TYR A 114
ASN A  96
 None
 1.42A 3hiiA-2xotA:
2.1		 3hiiA-2xotA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 TYR A 142
ASP A  67
SER A  90
TYR A 114
ASN A  96
 None
 1.45A 3hiiB-2xotA:
undetectable		 3hiiB-2xotA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 PRO A 174
LEU A 190
LEU A 163
LEU A 141
ILE A 170
 None
 1.06A 4a7aB-2xotA:
undetectable		 4a7aB-2xotA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 8 LEU A  93
LEU A 117
LEU A 139
VAL A 109
 None
 0.86A 4klaA-2xotA:
undetectable		 4klaA-2xotA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		6 / 10 LEU A 141
LEU A  91
LEU A  76
ILE A 101
LEU A  98
LEU A 125
 None
 1.39A 4odoA-2xotA:
undetectable		 4odoA-2xotA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		6 / 10 LEU A 141
LEU A  91
LEU A  76
ILE A 101
LEU A  98
LEU A 125
 None
 1.39A 4odoB-2xotA:
undetectable		 4odoB-2xotA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 7 LEU A 129
LEU A 165
LEU A 122
ILE A 170
 None
 0.97A 4okwA-2xotA:
undetectable		 4okwA-2xotA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 7 GLN A 248
TYR A 230
SER A 264
ASN A 261
 None
 1.16A 4ws0A-2xotA:
undetectable		 4ws0A-2xotA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		4 / 4 ASN A 195
LEU A 197
SER A 193
LEU A 216
 None
 1.34A 5kb5A-2xotA:
undetectable		 5kb5A-2xotA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		3 / 3 ALA A 342
GLN A 294
THR A 292
 None
 0.72A 5n0oA-2xotA:
undetectable		 5n0oA-2xotA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		5 / 12 ILE A 101
LEU A 192
PHE A 106
PHE A 154
LEU A 177
 None
 1.12A 6a93A-2xotA:
undetectable		 6a93A-2xotA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2xot AMPHOTERIN-INDUCED
PROTEIN 1
(Mus
musculus) 		3 / 3 SER A  48
LYS A  49
SER A  69
 None
 0.82A 6az3P-2xotA:
undetectable		 6az3P-2xotA:
10.99