SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 1d1vA-2xpiA:
1.1
1d1vB-2xpiA:
1.1		 1d1vA-2xpiA:
22.08
1d1vB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 1d1vA-2xpiA:
1.1
1d1vB-2xpiA:
1.0		 1d1vA-2xpiA:
22.08
1d1vB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 1d1wA-2xpiA:
1.1
1d1wB-2xpiA:
1.0		 1d1wA-2xpiA:
22.08
1d1wB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 1dm8A-2xpiA:
1.0
1dm8B-2xpiA:
1.0		 1dm8A-2xpiA:
22.08
1dm8B-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.46A 1dm8A-2xpiA:
1.1
1dm8B-2xpiA:
1.0		 1dm8A-2xpiA:
22.08
1dm8B-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 1dmiA-2xpiA:
1.8
1dmiB-2xpiA:
0.0		 1dmiA-2xpiA:
22.08
1dmiB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 1fopA-2xpiA:
0.0
1fopB-2xpiA:
1.1		 1fopA-2xpiA:
22.08
1fopB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 413
GLY A 412
 None
 1.02A 1mj2B-2xpiA:
undetectable		 1mj2B-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.29A 1mj2B-2xpiA:
undetectable		 1mj2B-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 413
GLY A 412
 None
 1.05A 1mj2D-2xpiA:
undetectable		 1mj2D-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.35A 1mj2D-2xpiA:
undetectable		 1mj2D-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 413
GLY A 412
 None
 1.05A 1mjoB-2xpiA:
undetectable		 1mjoB-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.28A 1mjoB-2xpiA:
undetectable		 1mjoB-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.26A 1mjoA-2xpiA:
undetectable		 1mjoA-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 413
GLY A 412
 None
 1.04A 1mjoD-2xpiA:
undetectable		 1mjoD-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.30A 1mjoD-2xpiA:
undetectable		 1mjoD-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 497
ALA A 494
PHE A 486
GLY A 482
 None
 1.32A 1mjoD-2xpiA:
undetectable		 1mjoD-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS A 415
ALA A 414
PHE A 413
GLY A 412
ALA A 426
 None
 1.16A 1mjqC-2xpiA:
undetectable
1mjqD-2xpiA:
undetectable		 1mjqC-2xpiA:
10.63
1mjqD-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 1nseA-2xpiA:
1.0
1nseB-2xpiA:
1.8		 1nseA-2xpiA:
22.08
1nseB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 1nseA-2xpiA:
1.1
1nseB-2xpiA:
1.8		 1nseA-2xpiA:
22.08
1nseB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 267
TYR A 260
TYR A 263
LEU A 295
LEU A 277
 None
 1.45A 1p33A-2xpiA:
undetectable		 1p33A-2xpiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 267
TYR A 260
TYR A 263
LEU A 295
LEU A 277
 None
 1.38A 1p33B-2xpiA:
undetectable		 1p33B-2xpiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 267
TYR A 260
TYR A 263
LEU A 295
LEU A 277
 None
 1.48A 1p33C-2xpiA:
undetectable		 1p33C-2xpiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.44A 1p6mA-2xpiA:
2.5
1p6mB-2xpiA:
0.0		 1p6mA-2xpiA:
20.39
1p6mB-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 1p6mA-2xpiA:
2.5
1p6mB-2xpiA:
0.0		 1p6mA-2xpiA:
20.39
1p6mB-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.44A 1p6nA-2xpiA:
1.8
1p6nB-2xpiA:
2.1		 1p6nA-2xpiA:
20.39
1p6nB-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 7 THR A 440
PHE A 437
PHE A 446
LEU A 344
 None
None
None
ACE  B   1 ( 4.0A)
 0.98A 1qcaA-2xpiA:
undetectable		 1qcaA-2xpiA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 127
LEU A 123
GLY A 115
ASP A 119
 None
 1.03A 1rmtC-2xpiA:
undetectable		 1rmtC-2xpiA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 1rs8A-2xpiA:
2.2
1rs8B-2xpiA:
undetectable		 1rs8A-2xpiA:
20.39
1rs8B-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.41A 1rs9A-2xpiA:
undetectable
1rs9B-2xpiA:
undetectable		 1rs9A-2xpiA:
20.39
1rs9B-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 464
SER A 467
TYR A 468
LEU A 481
 None
 1.23A 1xz1A-2xpiA:
undetectable		 1xz1A-2xpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 464
SER A 467
TYR A 468
LEU A 481
 None
 1.24A 1xz3A-2xpiA:
undetectable		 1xz3A-2xpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 279
GLU A 287
ALA A 291
TYR A 294
LEU A 295
 None
 1.24A 2azqA-2xpiA:
undetectable		 2azqA-2xpiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.93A 2bfpA-2xpiA:
undetectable		 2bfpA-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.91A 2bfpB-2xpiA:
undetectable		 2bfpB-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.93A 2bfpC-2xpiA:
undetectable		 2bfpC-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.91A 2bfpD-2xpiA:
undetectable		 2bfpD-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 400
PHE A 396
ALA A 392
LEU A 384
 None
 1.07A 2bxkA-2xpiA:
undetectable		 2bxkA-2xpiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 2hx2A-2xpiA:
undetectable
2hx2B-2xpiA:
undetectable		 2hx2A-2xpiA:
20.39
2hx2B-2xpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL A 505
ASN A 479
THR A 518
ALA A 516
SER A 546
 None
 1.36A 2ij7D-2xpiA:
0.0		 2ij7D-2xpiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL A 505
ASN A 479
THR A 518
ALA A 516
SER A 546
 None
 1.33A 2ij7F-2xpiA:
0.0		 2ij7F-2xpiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.44A 2nseA-2xpiA:
0.0
2nseB-2xpiA:
1.9		 2nseA-2xpiA:
22.08
2nseB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 317
ASN A 280
TRP A 252
 None
 1.02A 2y00B-2xpiA:
undetectable		 2y00B-2xpiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 481
LEU A 477
MET A 452
MET A 449
PHE A 498
 None
 1.48A 2yloA-2xpiA:
undetectable		 2yloA-2xpiA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 3n5qA-2xpiA:
0.0
3n5qB-2xpiA:
0.0		 3n5qA-2xpiA:
22.08
3n5qB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 3n5rA-2xpiA:
1.8
3n5rB-2xpiA:
1.1		 3n5rA-2xpiA:
22.08
3n5rB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 3n5rA-2xpiA:
1.8
3n5rB-2xpiA:
1.1		 3n5rA-2xpiA:
22.08
3n5rB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6B_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.34A 3n6bA-2xpiA:
2.2
3n6bB-2xpiA:
1.2		 3n6bA-2xpiA:
22.08
3n6bB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 3nlgA-2xpiA:
undetectable
3nlgB-2xpiA:
undetectable		 3nlgA-2xpiA:
22.08
3nlgB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 573
SER A 576
ALA A 550
LEU A 590
 None
 1.11A 3rd0A-2xpiA:
undetectable		 3rd0A-2xpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A 226
VAL A 229
ASP A 230
LEU A 198
 None
 0.73A 3roxA-2xpiA:
undetectable		 3roxA-2xpiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.44A 4c3aA-2xpiA:
2.3
4c3aB-2xpiA:
1.0		 4c3aA-2xpiA:
21.73
4c3aB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 4c3aA-2xpiA:
undetectable
4c3aB-2xpiA:
undetectable		 4c3aA-2xpiA:
21.73
4c3aB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 4cftA-2xpiA:
1.1
4cftB-2xpiA:
1.0		 4cftA-2xpiA:
21.73
4cftB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 4cftA-2xpiA:
1.0
4cftB-2xpiA:
1.2		 4cftA-2xpiA:
21.73
4cftB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 4cu1A-2xpiA:
2.2
4cu1B-2xpiA:
0.2		 4cu1A-2xpiA:
21.73
4cu1B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 4cu1A-2xpiA:
2.2
4cu1B-2xpiA:
0.0		 4cu1A-2xpiA:
21.73
4cu1B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 4cwvA-2xpiA:
undetectable
4cwvB-2xpiA:
undetectable		 4cwvA-2xpiA:
21.73
4cwvB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.50A 4cwvA-2xpiA:
2.3
4cwvB-2xpiA:
1.0		 4cwvA-2xpiA:
21.73
4cwvB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 4cwwA-2xpiA:
0.9
4cwwB-2xpiA:
0.0		 4cwwA-2xpiA:
21.73
4cwwB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 4cwxA-2xpiA:
2.3
4cwxB-2xpiA:
0.9		 4cwxA-2xpiA:
21.73
4cwxB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.46A 4cwxA-2xpiA:
undetectable
4cwxB-2xpiA:
undetectable		 4cwxA-2xpiA:
21.73
4cwxB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 4cwyA-2xpiA:
undetectable
4cwyB-2xpiA:
undetectable		 4cwyA-2xpiA:
21.73
4cwyB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 4cwyA-2xpiA:
undetectable
4cwyB-2xpiA:
undetectable		 4cwyA-2xpiA:
21.73
4cwyB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 4cwzA-2xpiA:
1.2
4cwzB-2xpiA:
1.2		 4cwzA-2xpiA:
21.79
4cwzB-2xpiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 4cwzA-2xpiA:
1.2
4cwzB-2xpiA:
1.0		 4cwzA-2xpiA:
21.79
4cwzB-2xpiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 4d1oA-2xpiA:
0.0
4d1oB-2xpiA:
1.0		 4d1oA-2xpiA:
20.66
4d1oB-2xpiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.46A 4d1oA-2xpiA:
undetectable
4d1oB-2xpiA:
undetectable		 4d1oA-2xpiA:
20.66
4d1oB-2xpiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 4d33A-2xpiA:
undetectable
4d33B-2xpiA:
undetectable		 4d33A-2xpiA:
21.73
4d33B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 4d33A-2xpiA:
0.7
4d33B-2xpiA:
0.0		 4d33A-2xpiA:
21.73
4d33B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.33A 4d35A-2xpiA:
1.8
4d35B-2xpiA:
1.0		 4d35A-2xpiA:
21.73
4d35B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 4d36A-2xpiA:
0.8
4d36B-2xpiA:
1.5		 4d36A-2xpiA:
21.73
4d36B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 4d37A-2xpiA:
undetectable
4d37B-2xpiA:
undetectable		 4d37A-2xpiA:
21.73
4d37B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 4d38A-2xpiA:
1.0
4d38B-2xpiA:
2.3		 4d38A-2xpiA:
21.73
4d38B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 4d38A-2xpiA:
1.0
4d38B-2xpiA:
2.3		 4d38A-2xpiA:
21.73
4d38B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 4d39A-2xpiA:
0.8
4d39B-2xpiA:
0.0		 4d39A-2xpiA:
21.73
4d39B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 4d39A-2xpiA:
0.6
4d39B-2xpiA:
0.0		 4d39A-2xpiA:
21.73
4d39B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 4d3aA-2xpiA:
2.0
4d3aB-2xpiA:
0.0		 4d3aA-2xpiA:
21.73
4d3aB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 503
LEU A 504
SER A 510
SER A 319
 None
 0.96A 4ikkA-2xpiA:
undetectable
4ikkB-2xpiA:
undetectable		 4ikkA-2xpiA:
12.61
4ikkB-2xpiA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 4imxA-2xpiA:
undetectable
4imxB-2xpiA:
undetectable		 4imxA-2xpiA:
21.73
4imxB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 4jsmA-2xpiA:
1.7
4jsmB-2xpiA:
1.1		 4jsmA-2xpiA:
21.73
4jsmB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.44A 4k5hA-2xpiA:
1.0
4k5hB-2xpiA:
1.1		 4k5hA-2xpiA:
21.73
4k5hB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.44A 4k5hA-2xpiA:
1.0
4k5hB-2xpiA:
1.1		 4k5hA-2xpiA:
21.73
4k5hB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 4k5iA-2xpiA:
2.3
4k5iB-2xpiA:
2.2		 4k5iA-2xpiA:
21.73
4k5iB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.46A 4k5iA-2xpiA:
2.3
4k5iB-2xpiA:
2.2		 4k5iA-2xpiA:
21.73
4k5iB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.42A 4k5jA-2xpiA:
2.1
4k5jB-2xpiA:
0.0		 4k5jA-2xpiA:
21.73
4k5jB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 4k5kA-2xpiA:
2.1
4k5kB-2xpiA:
0.0		 4k5kA-2xpiA:
21.73
4k5kB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 4kcpA-2xpiA:
1.3
4kcpB-2xpiA:
0.9		 4kcpA-2xpiA:
21.73
4kcpB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 4kcqA-2xpiA:
1.2
4kcqB-2xpiA:
1.2		 4kcqA-2xpiA:
21.73
4kcqB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 4kcqA-2xpiA:
1.2
4kcqB-2xpiA:
1.2		 4kcqA-2xpiA:
21.73
4kcqB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 4kcrA-2xpiA:
1.9
4kcrB-2xpiA:
1.2		 4kcrA-2xpiA:
21.73
4kcrB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 338
ASP A 306
ASP A 238
 None
 0.88A 4obwD-2xpiA:
undetectable		 4obwD-2xpiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 4uh8A-2xpiA:
2.2
4uh8B-2xpiA:
0.0		 4uh8A-2xpiA:
21.73
4uh8B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.44A 4uh8A-2xpiA:
2.2
4uh8B-2xpiA:
undetectable		 4uh8A-2xpiA:
21.73
4uh8B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 4uh9A-2xpiA:
2.1
4uh9B-2xpiA:
1.4		 4uh9A-2xpiA:
21.73
4uh9B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 4uh9A-2xpiA:
2.1
4uh9B-2xpiA:
1.4		 4uh9A-2xpiA:
21.73
4uh9B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.43A 4uhaA-2xpiA:
2.3
4uhaB-2xpiA:
1.2		 4uhaA-2xpiA:
21.73
4uhaB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 4upqA-2xpiA:
2.3
4upqB-2xpiA:
2.2		 4upqA-2xpiA:
21.73
4upqB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 4upqA-2xpiA:
undetectable
4upqB-2xpiA:
undetectable		 4upqA-2xpiA:
21.73
4upqB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  10
PHE A 486
ARG A 527
ILE B  12
 None
 1.29A 4zzcA-2xpiB:
undetectable
4zzcB-2xpiB:
undetectable		 4zzcA-2xpiB:
12.41
4zzcB-2xpiB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 5adjA-2xpiA:
2.4
5adjB-2xpiA:
1.2		 5adjA-2xpiA:
21.73
5adjB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.45A 5adjA-2xpiA:
undetectable
5adjB-2xpiA:
undetectable		 5adjA-2xpiA:
21.73
5adjB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 5adkA-2xpiA:
1.0
5adkB-2xpiA:
0.0		 5adkA-2xpiA:
21.73
5adkB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 5adkA-2xpiA:
1.0
5adkB-2xpiA:
0.0		 5adkA-2xpiA:
21.73
5adkB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 5adlA-2xpiA:
0.9
5adlB-2xpiA:
0.8		 5adlA-2xpiA:
21.73
5adlB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.44A 5admA-2xpiA:
undetectable
5admB-2xpiA:
undetectable		 5admA-2xpiA:
21.73
5admB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.47A 5adnA-2xpiA:
1.2
5adnB-2xpiA:
0.0		 5adnA-2xpiA:
21.73
5adnB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 5adnA-2xpiA:
1.1
5adnB-2xpiA:
0.0		 5adnA-2xpiA:
21.73
5adnB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 5 GLN A 499
HIS A 497
ILE A 495
TYR A 526
 None
 1.22A 5dnuA-2xpiA:
undetectable		 5dnuA-2xpiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 5 GLN A 499
HIS A 497
ILE A 495
TYR A 526
 None
 1.25A 5dnvA-2xpiA:
undetectable		 5dnvA-2xpiA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.46A 5fj2A-2xpiA:
1.2
5fj2B-2xpiA:
0.0		 5fj2A-2xpiA:
21.73
5fj2B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.47A 5fj2A-2xpiA:
undetectable
5fj2B-2xpiA:
undetectable		 5fj2A-2xpiA:
21.73
5fj2B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 5fj3A-2xpiA:
1.3
5fj3B-2xpiA:
1.1		 5fj3A-2xpiA:
21.73
5fj3B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 5fvyA-2xpiA:
1.9
5fvyB-2xpiA:
0.0		 5fvyA-2xpiA:
21.73
5fvyB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 5fvyA-2xpiA:
1.9
5fvyB-2xpiA:
0.0		 5fvyA-2xpiA:
21.73
5fvyB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 5uo9A-2xpiA:
undetectable
5uo9B-2xpiA:
0.0		 5uo9A-2xpiA:
20.66
5uo9B-2xpiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.50A 5uodA-2xpiA:
1.0
5uodB-2xpiA:
0.0		 5uodA-2xpiA:
21.73
5uodB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 559
ARG A 527
LEU A 543
ILE A 536
 None
 0.89A 5v0vA-2xpiA:
undetectable		 5v0vA-2xpiA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 248
VAL A 255
TYR A 234
ASP A 238
PHE A 237
 None
 1.37A 5vlmD-2xpiA:
1.4		 5vlmD-2xpiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 5vv7A-2xpiA:
1.1
5vv7B-2xpiA:
1.8		 5vv7A-2xpiA:
21.73
5vv7B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.45A 5vv9A-2xpiA:
undetectable
5vv9B-2xpiA:
undetectable		 5vv9A-2xpiA:
21.73
5vv9B-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.49A 5vvaA-2xpiA:
undetectable
5vvaB-2xpiA:
undetectable		 5vvaA-2xpiA:
21.73
5vvaB-2xpiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.48A 6av7C-2xpiA:
0.0
6av7D-2xpiA:
0.0		 6av7C-2xpiA:
8.01
6av7D-2xpiA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 4 GLY A 115
ARG A  88
ASN A 116
LEU A 111
 None
 1.42A 6b58A-2xpiA:
4.2		 6b58A-2xpiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 365
ALA A 378
LEU A 332
THR A 328
 None
 0.91A 6f88B-2xpiA:
undetectable		 6f88B-2xpiA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 505
ARG B   4
TRP A 515
PHE A 321
 None
 1.43A 8nseA-2xpiA:
1.9
8nseB-2xpiA:
1.0		 8nseA-2xpiA:
22.08
8nseB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.46A 8nseA-2xpiA:
undetectable
8nseB-2xpiA:
undetectable		 8nseA-2xpiA:
22.08
8nseB-2xpiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.48A 9nseA-2xpiA:
0.0
9nseB-2xpiA:
1.1		 9nseA-2xpiA:
22.08
9nseB-2xpiA:
22.08