SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2xpp IWS1
(Encephalitozoon
cuniculi) 		3 / 3 ALA A 182
VAL A 184
TRP A 187
 None
 0.91A 1nt5B-2xppA:
undetectable		 1nt5B-2xppA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2xpp IWS1
(Encephalitozoon
cuniculi) 		3 / 3 ILE A 136
MET A  70
ARG A  69
 None
 0.86A 4lnwA-2xppA:
undetectable		 4lnwA-2xppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2xpp IWS1
(Encephalitozoon
cuniculi) 		3 / 3 ILE A 136
MET A  70
ARG A  69
 None
 0.85A 4lnxA-2xppA:
undetectable		 4lnxA-2xppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2xpp IWS1
(Encephalitozoon
cuniculi) 		5 / 12 GLY A 160
VAL A 159
ILE A 162
ILE A 149
LEU A 141
 None
 1.05A 4pd4C-2xppA:
undetectable		 4pd4C-2xppA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2xpp CHROMATIN STRUCTURE
MODULATOR
IWS1
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 141
VAL A 143
LEU A 116
TYR B  63
GLY A 121
 None
 1.31A 5i8fA-2xppA:
undetectable		 5i8fA-2xppA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xpp IWS1
CHROMATIN STRUCTURE
MODULATOR
(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		4 / 6 ILE B  56
ILE A 115
LEU A 111
HIS A 150
 None
 0.96A 5vkqB-2xppB:
undetectable
5vkqC-2xppB:
undetectable		 5vkqB-2xppB:
2.36
5vkqC-2xppB:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xpp IWS1
CHROMATIN STRUCTURE
MODULATOR
(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		4 / 6 ILE B  56
ILE A 115
LEU A 111
HIS A 150
 None
 0.94A 5vkqC-2xppB:
undetectable
5vkqD-2xppB:
undetectable		 5vkqC-2xppB:
2.36
5vkqD-2xppB:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2xpp IWS1
(Encephalitozoon
cuniculi) 		5 / 11 ASP A 117
LEU A 123
LEU A 101
ILE A 149
MET A 147
 None
 1.39A 6fgcA-2xppA:
undetectable		 6fgcA-2xppA:
17.61