SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 243
GLN A  92
ILE A 155
ASN A 154
LEU A 153
 None
 1.20A 1dhfB-2xpzA:
undetectable		 1dhfB-2xpzA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 243
GLN A  92
ILE A 155
ASN A 154
LEU A 153
 None
 1.12A 1dlsA-2xpzA:
undetectable		 1dlsA-2xpzA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 586
LEU A 527
LEU A 582
GLU A 522
 None
 1.02A 1i7zA-2xpzA:
2.4		 1i7zA-2xpzA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.90A 1j36A-2xpzA:
5.3		 1j36A-2xpzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.91A 1j36B-2xpzA:
5.4		 1j36B-2xpzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.91A 1j37A-2xpzA:
5.9		 1j37A-2xpzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.91A 1j37B-2xpzA:
5.3		 1j37B-2xpzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 597
HIS A 340
GLU A 341
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-2.2A)
None
 1.20A 1o86A-2xpzA:
5.2		 1o86A-2xpzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.92A 1o86A-2xpzA:
5.2		 1o86A-2xpzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 390
ILE A 389
VAL A 367
SER A 386
 None
 1.01A 1rs7B-2xpzA:
undetectable		 1rs7B-2xpzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.88A 2c6nA-2xpzA:
5.8		 2c6nA-2xpzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.95A 2c6nB-2xpzA:
7.0		 2c6nB-2xpzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  74
LEU A  76
VAL A  78
PHE A 218
LEU A 185
 None
 1.23A 2q6hA-2xpzA:
undetectable		 2q6hA-2xpzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.88A 2x8zA-2xpzA:
6.0		 2x8zA-2xpzA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.89A 2x91A-2xpzA:
undetectable		 2x91A-2xpzA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A  90
GLN A 156
ASP A  73
SER A  88
 None
 1.34A 2xz5A-2xpzA:
3.1
2xz5C-2xpzA:
3.0		 2xz5A-2xpzA:
16.88
2xz5C-2xpzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 285
ILE A 338
LEU A 552
ASP A 393
GLU A 430
 None
 1.41A 3aocC-2xpzA:
undetectable		 3aocC-2xpzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 366
LEU A 369
GLY A 348
ILE A 293
VAL A 239
 ZN  A1673 ( 4.8A)
None
None
None
None
 0.85A 3frqB-2xpzA:
undetectable		 3frqB-2xpzA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 452
ILE A 453
THR A 473
VAL A 351
 None
 0.91A 3me6B-2xpzA:
undetectable		 3me6B-2xpzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 570
ILE A 542
LEU A 583
THR A 530
 None
 1.28A 3nxuA-2xpzA:
undetectable		 3nxuA-2xpzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 109
GLU A 130
SER A 201
 None
 0.63A 3p2kA-2xpzA:
undetectable		 3p2kA-2xpzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 485
LEU A 471
HIS A 438
VAL A 411
 None
 0.78A 3r9vA-2xpzA:
undetectable
3r9vB-2xpzA:
undetectable		 3r9vA-2xpzA:
18.44
3r9vB-2xpzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 340
GLU A 341
HIS A 344
GLU A 363
TYR A 429
 ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
ZN  A1673 (-2.2A)
None
 0.94A 4c2pA-2xpzA:
undetectable		 4c2pA-2xpzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 639
LEU A 671
GLY A 634
VAL A 665
GLY A 623
 None
 0.87A 4dc3A-2xpzA:
undetectable		 4dc3A-2xpzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 639
LEU A 671
GLY A 634
VAL A 665
GLY A 623
 None
 0.92A 4dc3B-2xpzA:
undetectable		 4dc3B-2xpzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 452
LEU A 435
LEU A 436
LEU A 471
LEU A 485
 None
 1.18A 4dm8A-2xpzA:
undetectable		 4dm8A-2xpzA:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 313
HIS A 340
GLU A 341
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-2.2A)
None
 0.89A 4dprA-2xpzA:
43.1		 4dprA-2xpzA:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 314
HIS A 340
GLU A 341
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-2.2A)
None
 1.10A 4dprA-2xpzA:
43.1		 4dprA-2xpzA:
40.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 457
TYR A 456
PHE A 452
ILE A 293
 None
 1.17A 4jx1E-2xpzA:
undetectable		 4jx1E-2xpzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 390
ILE A 389
VAL A 367
SER A 386
 None
 0.99A 4kcnA-2xpzA:
undetectable		 4kcnA-2xpzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 198
VAL A  69
PHE A  91
SER A  62
THR A  72
 None
 1.28A 4mmaA-2xpzA:
undetectable		 4mmaA-2xpzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 436
HIS A 344
HIS A 340
GLU A 363
 None
ZN  A1673 (-3.5A)
ZN  A1673 (-3.3A)
ZN  A1673 (-2.2A)
 0.92A 4pahA-2xpzA:
undetectable		 4pahA-2xpzA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		8 / 12 ALA A 187
HIS A 340
GLU A 341
HIS A 344
TRP A 356
PHE A 359
GLU A 363
TYR A 429
 None
ZN  A1673 (-3.3A)
None
ZN  A1673 (-3.5A)
None
None
ZN  A1673 (-2.2A)
None
 0.65A 4r7lA-2xpzA:
51.2		 4r7lA-2xpzA:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 187
HIS A 340
HIS A 344
TRP A 356
PHE A 359
LEU A 414
TYR A 429
 None
ZN  A1673 (-3.3A)
ZN  A1673 (-3.5A)
None
None
None
None
 0.60A 4r7lA-2xpzA:
51.2		 4r7lA-2xpzA:
40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 485
ILE A 484
LEU A 443
GLU A 448
 None
 0.89A 4w5nA-2xpzA:
3.4		 4w5nA-2xpzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 517
GLN A 606
LEU A 583
LEU A 557
LEU A 582
 None
 1.29A 4x30A-2xpzA:
undetectable		 4x30A-2xpzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 394
SER A 408
PRO A 404
PHE A 407
 None
 1.27A 5b8iA-2xpzA:
undetectable		 5b8iA-2xpzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 430
GLY A 390
ARG A 371
PHE A 505
 None
 1.05A 5jcnB-2xpzA:
undetectable		 5jcnB-2xpzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 414
ALA A 423
PHE A 407
TYR A 495
LEU A 435
 None
 1.41A 5ljbA-2xpzA:
undetectable		 5ljbA-2xpzA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 338
ILE A 335
ILE A 377
ILE A 373
ILE A 374
 None
 0.94A 5murE-2xpzA:
4.6		 5murE-2xpzA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 406
PHE A 359
LEU A 414
 None
 0.92A 5x1bC-2xpzA:
undetectable		 5x1bC-2xpzA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 248
ASN A  75
THR A 159
PHE A 157
 None
 1.09A 5x23A-2xpzA:
undetectable		 5x23A-2xpzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  76
GLY A 247
ALA A 208
PRO A 318
GLU A 316
 None
None
None
None
ZN  A1673 ( 4.5A)
 1.25A 5x6yC-2xpzA:
undetectable		 5x6yC-2xpzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  48
ILE A  45
SER A  44
 None
 0.81A 5zw2A-2xpzA:
undetectable		 5zw2A-2xpzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 485
ILE A 484
LYS A 459
GLY A 444
LEU A 439
 None
 1.15A 6a7pA-2xpzA:
undetectable		 6a7pA-2xpzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 189
THR A 199
PRO A 135
GLY A 137
LEU A 136
 None
 1.14A 6b0lB-2xpzA:
undetectable		 6b0lB-2xpzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 319
GLU A 236
GLN A 237
PRO A 318
GLY A 247
 None
 1.42A 6gnfC-2xpzA:
undetectable		 6gnfC-2xpzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 327
THR A 324
GLY A 313
ARG A 627
 None
 1.20A 6gtqB-2xpzA:
undetectable
6gtqD-2xpzA:
undetectable		 6gtqB-2xpzA:
16.94
6gtqD-2xpzA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 436
HIS A 344
HIS A 340
GLU A 363
 None
ZN  A1673 (-3.5A)
ZN  A1673 (-3.3A)
ZN  A1673 (-2.2A)
 0.96A 6pahA-2xpzA:
undetectable		 6pahA-2xpzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2xpz LEUKOTRIENE A-4
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  45
TRP A 490
LEU A 485
ASP A 472
PHE A 468
 None
 1.32A 6r2eG-2xpzA:
undetectable		 6r2eG-2xpzA:
18.57