SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2xqr INVERTASE INHIBITOR
(Nicotiana
tabacum) 		3 / 3 ALA B  88
GLY B 139
SER B 107
 None
 0.58A 2ivuA-2xqrB:
2.3		 2ivuA-2xqrB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2xqr INVERTASE INHIBITOR
(Nicotiana
tabacum) 		4 / 8 ILE B  43
LEU B  85
ARG B 140
GLY B 103
 None
 0.82A 2vdbA-2xqrB:
undetectable		 2vdbA-2xqrB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2xqr INVERTASE INHIBITOR
(Nicotiana
tabacum) 		4 / 8 LEU B  22
ILE B  38
VAL B 138
THR B  11
 None
 0.80A 4ma7A-2xqrB:
undetectable		 4ma7A-2xqrB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2xqr INVERTASE INHIBITOR
(Nicotiana
tabacum) 		5 / 9 ALA B 100
GLY B 106
ILE B  80
ILE B 142
VAL B 143
 None
 1.10A 4nptA-2xqrB:
undetectable		 4nptA-2xqrB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2xqr INVERTASE INHIBITOR
(Nicotiana
tabacum) 		3 / 3 LEU B  81
VAL B  40
ASP B  41
 EPE  B1000 (-4.0A)
None
None
 0.65A 4y8wC-2xqrB:
undetectable		 4y8wC-2xqrB:
16.71