SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		3 / 3 TRP A  84
ALA A 149
VAL A 154
 None
 0.97A 1bdwA-2xqwA:
undetectable
1bdwB-2xqwA:
undetectable		 1bdwA-2xqwA:
4.72
1bdwB-2xqwA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 6 LEU A  85
GLY A  18
ILE A 132
HIS A 133
 None
 0.80A 1yajF-2xqwA:
undetectable		 1yajF-2xqwA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		5 / 12 THR A 276
ILE A 137
VAL A 131
ILE A  23
LEU A  85
 None
 1.21A 1z9hD-2xqwA:
2.0		 1z9hD-2xqwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 7 ALA A  31
ASP A  36
LEU A  35
ARG A  49
 None
 0.78A 2uyqA-2xqwA:
undetectable		 2uyqA-2xqwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		3 / 3 PRO A 212
LEU A 213
ARG A 208
 None
 0.62A 3aqiB-2xqwA:
undetectable		 3aqiB-2xqwA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 8 SER A  94
LEU A  95
PHE A 280
GLN A 205
 None
 1.21A 4j7uD-2xqwA:
undetectable		 4j7uD-2xqwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 6 LEU A  95
ILE A  23
THR A  26
MET A 136
 None
 1.37A 5ljeA-2xqwA:
undetectable		 5ljeA-2xqwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 5 TYR A 268
TYR A 269
GLY A 270
GLY A 271
 None
 0.95A 5x7pA-2xqwA:
undetectable		 5x7pA-2xqwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 6 TYR A 268
TYR A 269
GLY A 270
GLY A 271
 None
 0.97A 5x7pB-2xqwA:
undetectable		 5x7pB-2xqwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		4 / 7 VAL A  89
VAL A  29
GLY A  59
TYR A  60
 None
 1.00A 5x80C-2xqwA:
0.6
5x80D-2xqwA:
0.7		 5x80C-2xqwA:
20.61
5x80D-2xqwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2xqw COMPLEMENT C3
(Homo
sapiens) 		5 / 12 GLN A 290
VAL A 282
TYR A 268
THR A 279
LEU A  10
 None
 1.29A 6ak3A-2xqwA:
1.2		 6ak3A-2xqwA:
14.08