SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 HIS A 244
GLY A 579
HIS A 329
GLU A 377
ASP A 246
 ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.5A)
None
ZN  A1639 (-2.7A)
 1.35A 1a4lD-2xr1A:
undetectable		 1a4lD-2xr1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 5 THR A 269
THR A 266
THR A 350
HIS A 247
 None
None
None
ZN  A1639 (-3.3A)
 1.38A 1d4fB-2xr1A:
undetectable		 1d4fB-2xr1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.14A 1dfoA-2xr1A:
undetectable		 1dfoA-2xr1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.14A 1dfoB-2xr1A:
undetectable		 1dfoB-2xr1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.14A 1dfoC-2xr1A:
undetectable		 1dfoC-2xr1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.14A 1dfoD-2xr1A:
undetectable		 1dfoD-2xr1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 5 HIS A 247
HIS A 329
HIS A 580
HIS A 604
ASP A 246
 ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
None
ZN  A1639 (-3.3A)
ZN  A1639 (-2.7A)
 1.20A 1e9yB-2xr1A:
undetectable		 1e9yB-2xr1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.13A 1eqbA-2xr1A:
undetectable		 1eqbA-2xr1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.13A 1eqbB-2xr1A:
undetectable		 1eqbB-2xr1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.13A 1eqbC-2xr1A:
undetectable		 1eqbC-2xr1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.13A 1eqbD-2xr1A:
undetectable		 1eqbD-2xr1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 6 HIS A 247
HIS A 329
HIS A 580
HIS A 604
ASP A 246
 ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
None
ZN  A1639 (-3.3A)
ZN  A1639 (-2.7A)
 1.19A 1fweC-2xr1A:
undetectable		 1fweC-2xr1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 GLU A  15
HIS A  12
ASP A  26
 None
 0.78A 1i9gA-2xr1A:
3.2		 1i9gA-2xr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 PHE A 338
LEU A 636
VAL A 183
PHE A 349
VAL A 347
 None
 1.39A 1q23K-2xr1A:
undetectable		 1q23K-2xr1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 586
THR A 350
ASP A 352
GLY A 605
HIS A 604
 None
None
ZN  A1639 ( 2.3A)
None
ZN  A1639 (-3.3A)
 1.33A 1v8bA-2xr1A:
undetectable		 1v8bA-2xr1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 586
THR A 350
ASP A 352
GLY A 605
HIS A 604
 None
None
ZN  A1639 ( 2.3A)
None
ZN  A1639 (-3.3A)
 1.35A 1v8bB-2xr1A:
undetectable		 1v8bB-2xr1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 VAL A  27
ILE A  24
LEU A  36
LEU A  58
LEU A  54
 None
 1.25A 2a15A-2xr1A:
undetectable		 2a15A-2xr1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 ASP A 315
LYS A 321
PHE A 324
ASP A 309
 None
 0.94A 2aouA-2xr1A:
undetectable		 2aouA-2xr1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 VAL A 274
LEU A 278
TYR A 293
GLY A 296
ALA A 299
 None
 1.11A 2aylA-2xr1A:
undetectable		 2aylA-2xr1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 THR A 269
THR A 301
VAL A 251
GLY A 249
VAL A 298
 None
 1.37A 2cp4A-2xr1A:
undetectable		 2cp4A-2xr1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 7 SER A 195
ASP A 209
VAL A 192
LEU A 586
 None
 0.97A 2hdnE-2xr1A:
undetectable
2hdnF-2xr1A:
undetectable
2hdnH-2xr1A:
undetectable		 2hdnE-2xr1A:
6.81
2hdnF-2xr1A:
20.68
2hdnH-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 7 VAL A 192
LEU A 586
SER A 195
ASP A 209
 None
 1.01A 2hdnF-2xr1A:
undetectable
2hdnG-2xr1A:
undetectable
2hdnH-2xr1A:
undetectable		 2hdnF-2xr1A:
20.68
2hdnG-2xr1A:
6.81
2hdnH-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 6 THR A 241
SER A 195
ASP A 209
VAL A 192
 None
 1.12A 2hdnI-2xr1A:
undetectable
2hdnJ-2xr1A:
undetectable
2hdnL-2xr1A:
undetectable		 2hdnI-2xr1A:
6.81
2hdnJ-2xr1A:
20.68
2hdnL-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 6 VAL A 192
THR A 241
SER A 195
ASP A 209
 None
 1.11A 2hdnJ-2xr1A:
undetectable
2hdnK-2xr1A:
undetectable
2hdnL-2xr1A:
undetectable		 2hdnJ-2xr1A:
20.68
2hdnK-2xr1A:
6.81
2hdnL-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 HIS A 244
ILE A 330
GLY A 579
HIS A 604
ASP A 246
 ZN  A1638 (-3.0A)
None
None
ZN  A1639 (-3.3A)
ZN  A1639 (-2.7A)
 1.11A 2pgfA-2xr1A:
undetectable		 2pgfA-2xr1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 HIS A 242
HIS A 244
HIS A 329
GLU A 377
ASP A 246
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1638 (-3.5A)
None
ZN  A1639 (-2.7A)
 1.05A 2pgrA-2xr1A:
undetectable		 2pgrA-2xr1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 HIS A 244
ILE A 330
GLY A 579
HIS A 604
ASP A 246
 ZN  A1638 (-3.0A)
None
None
ZN  A1639 (-3.3A)
ZN  A1639 (-2.7A)
 1.06A 2pgrA-2xr1A:
undetectable		 2pgrA-2xr1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 ASP A 246
HIS A 247
HIS A 329
ASP A 352
HIS A 604
 ZN  A1639 (-2.7A)
ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
ZN  A1639 ( 2.3A)
ZN  A1639 (-3.3A)
 0.63A 2q0jB-2xr1A:
12.1		 2q0jB-2xr1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 VAL A 412
PHE A 520
THR A 541
ASN A 512
GLY A 514
 None
 1.28A 2x2iC-2xr1A:
undetectable		 2x2iC-2xr1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 4 LEU A 308
GLN A  33
THR A 314
THR A 305
 None
 1.44A 2zj0D-2xr1A:
undetectable		 2zj0D-2xr1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 HIS A 244
ILE A 330
HIS A 242
HIS A 604
HIS A 580
 ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.2A)
ZN  A1639 (-3.3A)
None
 1.50A 2zwfA-2xr1A:
undetectable
2zwfB-2xr1A:
undetectable		 2zwfA-2xr1A:
18.35
2zwfB-2xr1A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
 None
 1.21A 3a51A-2xr1A:
undetectable		 3a51A-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
 None
 1.19A 3a51C-2xr1A:
undetectable		 3a51C-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
 None
 1.21A 3a51D-2xr1A:
undetectable		 3a51D-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
 None
 1.23A 3a51E-2xr1A:
undetectable		 3a51E-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 ALA A 451
LEU A 331
ILE A 470
LEU A 466
PHE A 478
 None
 1.15A 3fl9C-2xr1A:
undetectable		 3fl9C-2xr1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 ALA A 451
LEU A 331
ILE A 470
LEU A 466
PHE A 478
 None
 1.11A 3fl9E-2xr1A:
undetectable		 3fl9E-2xr1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 451
LEU A 331
ILE A 470
LEU A 466
PHE A 478
 None
 1.15A 3fl9G-2xr1A:
undetectable		 3fl9G-2xr1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 ASP A 279
LEU A 275
GLN A 422
 None
 0.74A 3g4lA-2xr1A:
undetectable		 3g4lA-2xr1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A  23
LYS A 160
GLU A  15
 None
 0.95A 3ijdB-2xr1A:
undetectable		 3ijdB-2xr1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 ALA A 451
LEU A 331
ILE A 470
LEU A 466
PHE A 478
 None
 1.11A 3jw5B-2xr1A:
2.2		 3jw5B-2xr1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 PHE A 197
PHE A 349
GLY A 211
PHE A 601
 None
 1.06A 3ko0B-2xr1A:
undetectable
3ko0J-2xr1A:
undetectable		 3ko0B-2xr1A:
9.52
3ko0J-2xr1A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 7 PHE A 197
PHE A 349
GLY A 211
PHE A 601
 None
 1.04A 3ko0K-2xr1A:
undetectable
3ko0S-2xr1A:
undetectable		 3ko0K-2xr1A:
9.52
3ko0S-2xr1A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 378
GLY A 605
ASP A 582
LEU A 586
ALA A 627
 None
 1.05A 3ou6A-2xr1A:
undetectable		 3ou6A-2xr1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 5 ASN A 512
ASP A 246
GLU A 603
SER A 508
 None
ZN  A1639 (-2.7A)
None
None
 1.45A 3p2kC-2xr1A:
undetectable		 3p2kC-2xr1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 TYR A 353
HIS A 580
ASP A 352
GLY A 535
PHE A 416
 None
None
ZN  A1639 ( 2.3A)
None
None
 1.13A 3sufC-2xr1A:
undetectable		 3sufC-2xr1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 PHE A 338
LEU A 636
VAL A 183
PHE A 349
VAL A 347
 None
 1.41A 3u9fJ-2xr1A:
undetectable
3u9fK-2xr1A:
undetectable		 3u9fJ-2xr1A:
15.11
3u9fK-2xr1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 PHE A 338
LEU A 636
VAL A 183
PHE A 349
VAL A 347
 None
 1.44A 3u9fR-2xr1A:
undetectable		 3u9fR-2xr1A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 327
ASN A 326
ASP A 246
ASP A 209
HIS A 604
 None
None
ZN  A1639 (-2.7A)
None
ZN  A1639 (-3.3A)
 1.31A 3w37A-2xr1A:
undetectable		 3w37A-2xr1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 327
ASN A 326
ASP A 246
ASP A 209
HIS A 604
 None
None
ZN  A1639 (-2.7A)
None
ZN  A1639 (-3.3A)
 1.32A 3welA-2xr1A:
undetectable		 3welA-2xr1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 327
ASN A 326
ASP A 246
ASP A 209
HIS A 604
 None
None
ZN  A1639 (-2.7A)
None
ZN  A1639 (-3.3A)
 1.33A 3wemA-2xr1A:
undetectable		 3wemA-2xr1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 327
ASN A 326
ASP A 246
ASP A 209
HIS A 604
 None
None
ZN  A1639 (-2.7A)
None
ZN  A1639 (-3.3A)
 1.32A 3wenA-2xr1A:
undetectable		 3wenA-2xr1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ALA A 327
ASN A 326
ASP A 246
ASP A 209
HIS A 604
 None
None
ZN  A1639 (-2.7A)
None
ZN  A1639 (-3.3A)
 1.34A 3weoA-2xr1A:
undetectable		 3weoA-2xr1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 HIS A 242
HIS A 244
ASP A 246
HIS A 329
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.84A 4c1dB-2xr1A:
8.9		 4c1dB-2xr1A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 HIS A 242
HIS A 244
ASP A 246
HIS A 329
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.85A 4c1fA-2xr1A:
9.5
4c1fB-2xr1A:
2.7		 4c1fA-2xr1A:
17.17
4c1fB-2xr1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 VAL A 214
HIS A 242
HIS A 244
HIS A 329
HIS A 604
 None
ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.87A 4c1fA-2xr1A:
9.5
4c1fB-2xr1A:
2.7		 4c1fA-2xr1A:
17.17
4c1fB-2xr1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 9 HIS A 242
HIS A 244
ASP A 246
HIS A 329
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.85A 4c1hA-2xr1A:
undetectable		 4c1hA-2xr1A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 HIS A 244
ASP A 246
HIS A 329
HIS A 604
 ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.77A 4exsB-2xr1A:
9.9		 4exsB-2xr1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 5 HIS A 247
HIS A 329
HIS A 580
HIS A 604
ASP A 246
 ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
None
ZN  A1639 (-3.3A)
ZN  A1639 (-2.7A)
 1.18A 4h9mA-2xr1A:
undetectable		 4h9mA-2xr1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 GLU A 161
GLY A 261
ALA A 237
ILE A 316
ARG A 168
 None
 1.18A 4hytA-2xr1A:
undetectable		 4hytA-2xr1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 GLU A 161
GLY A 261
ALA A 237
ILE A 316
ARG A 168
 None
 1.17A 4hytC-2xr1A:
undetectable		 4hytC-2xr1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 5 TYR A  94
THR A  73
PHE A  96
ILE A  80
 None
 1.25A 4jx1E-2xr1A:
undetectable		 4jx1E-2xr1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 HIS A  12
ASP A   5
LEU A   8
ASP A  26
 None
 0.98A 4k0bA-2xr1A:
undetectable		 4k0bA-2xr1A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 HIS A  12
ASP A   5
LEU A   8
ASP A  26
 None
 0.96A 4l7iA-2xr1A:
undetectable		 4l7iA-2xr1A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 636
ARG A 182
ALA A 317
ILE A 375
LEU A 198
 None
 1.16A 4l9qA-2xr1A:
undetectable		 4l9qA-2xr1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 6 ASP A 362
ASN A 326
ALA A 364
TYR A 355
 None
 1.03A 4mdbA-2xr1A:
undetectable		 4mdbA-2xr1A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 250
GLY A 249
VAL A 214
MET A 273
VAL A 418
 None
 1.41A 4okxA-2xr1A:
undetectable		 4okxA-2xr1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ILE A 104
ILE A 148
PRO A  98
VAL A 274
THR A 144
 None
 1.00A 4q5mA-2xr1A:
undetectable		 4q5mA-2xr1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 8 VAL A 192
HIS A 244
ASP A 246
HIS A 329
HIS A 604
 None
ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 1.05A 5a5zA-2xr1A:
9.9		 5a5zA-2xr1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 PRO A 414
PHE A 416
PHE A 533
TYR A 380
 None
 1.24A 5amkA-2xr1A:
undetectable		 5amkA-2xr1A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		6 / 11 HIS A 242
HIS A 244
ASP A 246
HIS A 247
HIS A 329
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.44A 5ayaA-2xr1A:
11.8		 5ayaA-2xr1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 GLU A  15
HIS A  12
ASP A  26
 None
 0.79A 5c0oG-2xr1A:
3.2		 5c0oG-2xr1A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 SER A 142
ALA A 453
LEU A 275
LEU A 272
 None
 1.20A 5dzkF-2xr1A:
undetectable
5dzkT-2xr1A:
undetectable		 5dzkF-2xr1A:
15.70
5dzkT-2xr1A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 9 HIS A 242
TYR A 353
GLY A 351
HIS A 329
HIS A 247
 ZN  A1638 (-3.2A)
None
None
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 1.46A 5f8yA-2xr1A:
undetectable		 5f8yA-2xr1A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 ILE A 128
TRP A 130
ILE A  91
PHE A  96
 None
 0.93A 5hw8H-2xr1A:
undetectable		 5hw8H-2xr1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 ILE A 375
LEU A 628
HIS A 244
GLY A 351
HIS A 329
 None
None
ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.5A)
 1.00A 5l6eA-2xr1A:
undetectable		 5l6eA-2xr1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 HIS A 580
HIS A 604
HIS A 242
HIS A 244
LEU A 245
 None
ZN  A1639 (-3.3A)
ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
None
 1.30A 5m8nA-2xr1A:
undetectable		 5m8nA-2xr1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 HIS A 580
HIS A 604
HIS A 242
HIS A 244
LEU A 245
 None
ZN  A1639 (-3.3A)
ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
None
 1.34A 5m8nB-2xr1A:
0.0		 5m8nB-2xr1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 ASP A 352
HIS A 247
HIS A 604
HIS A 329
 ZN  A1639 ( 2.3A)
ZN  A1639 (-3.3A)
ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
 0.92A 5nekD-2xr1A:
undetectable		 5nekD-2xr1A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 HIS A 580
VAL A 214
GLY A 193
GLY A 211
HIS A 604
 None
None
None
None
ZN  A1639 (-3.3A)
 1.22A 5nnaB-2xr1A:
undetectable		 5nnaB-2xr1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		7 / 10 HIS A 242
HIS A 244
HIS A 247
HIS A 329
ASP A 352
TYR A 380
HIS A 580
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
ZN  A1639 ( 2.3A)
None
None
 0.40A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 HIS A 242
HIS A 329
HIS A 247
THR A 602
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
None
ZN  A1639 (-3.3A)
 1.09A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 10 HIS A 329
HIS A 242
HIS A 580
ASP A 352
HIS A 604
 ZN  A1638 (-3.5A)
ZN  A1638 (-3.2A)
None
ZN  A1639 ( 2.3A)
ZN  A1639 (-3.3A)
 0.96A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 12 LEU A 586
THR A 350
ASP A 352
GLY A 605
HIS A 604
 None
None
ZN  A1639 ( 2.3A)
None
ZN  A1639 (-3.3A)
 1.37A 5utuF-2xr1A:
undetectable		 5utuF-2xr1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 (-3.5A)
 0.87A 5xioA-2xr1A:
undetectable		 5xioA-2xr1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 (-3.5A)
 0.87A 5xiqB-2xr1A:
undetectable		 5xiqB-2xr1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 THR A 379
GLU A 377
HIS A 329
 None
None
ZN  A1638 (-3.5A)
 0.90A 5xiqD-2xr1A:
undetectable		 5xiqD-2xr1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		5 / 11 HIS A 244
ILE A 330
HIS A 242
HIS A 604
HIS A 580
 ZN  A1638 (-3.0A)
None
ZN  A1638 (-3.2A)
ZN  A1639 (-3.3A)
None
 1.48A 5z0mA-2xr1A:
undetectable
5z0mB-2xr1A:
undetectable		 5z0mA-2xr1A:
8.12
5z0mB-2xr1A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 8 HIS A 244
ASP A 246
HIS A 329
HIS A 604
 ZN  A1638 (-3.0A)
ZN  A1639 (-2.7A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
 0.82A 5zj8A-2xr1A:
9.9		 5zj8A-2xr1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		3 / 3 GLY A  21
THR A  23
GLU A  40
 None
 0.63A 6b58A-2xr1A:
undetectable		 6b58A-2xr1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT
(Methanosarcina
mazei) 		4 / 4 LEU A 156
ASP A  99
PRO A  98
ARG A 159
 None
 1.36A 6fgdA-2xr1A:
undetectable		 6fgdA-2xr1A:
21.60