SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 9 ASN A 104
ILE A 107
GLY A 106
LEU A  52
ASP A  97
 None
 1.47A 1dgmA-2xr4A:
undetectable		 1dgmA-2xr4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		4 / 4 ILE A  93
LEU A   8
VAL A  64
ILE A  30
 None
 0.93A 1fm6D-2xr4A:
undetectable		 1fm6D-2xr4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 12 ASP A  97
SER A  95
VAL A  68
SER A  75
THR A  20
 None
 1.27A 3mbhB-2xr4A:
undetectable		 3mbhB-2xr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 12 ASP A  97
SER A  95
VAL A  68
SER A  75
THR A  20
 None
 1.26A 3mbhC-2xr4A:
undetectable		 3mbhC-2xr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 12 ASP A  97
SER A  95
VAL A  68
SER A  75
THR A  20
 None
 1.26A 3mbhD-2xr4A:
undetectable		 3mbhD-2xr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 12 ASP A  97
SER A  95
VAL A  68
SER A  75
THR A  20
 None
 1.25A 3mbhE-2xr4A:
undetectable		 3mbhE-2xr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		3 / 3 ARG A  65
ARG A  63
ILE A  67
 None
 0.86A 4b7qC-2xr4A:
undetectable		 4b7qC-2xr4A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2xr4 LECTIN
(Burkholderia
cenocepacia) 		5 / 12 ILE A  28
ILE A  67
ARG A  73
SER A  75
LEU A  77
 None
 0.98A 4mwzA-2xr4A:
undetectable		 4mwzA-2xr4A:
16.35