SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL H 211
TYR H 194
VAL H 184
SER H 130
 None
 1.19A 2x45A-2xraH:
undetectable		 2x45A-2xraH:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER H 128
LEU H 124
ALA H 137
SER H 127
 None
 0.84A 4ikjA-2xraH:
3.4
4ikjB-2xraH:
undetectable		 4ikjA-2xraH:
22.83
4ikjB-2xraH:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 LEU H 124
ALA H 137
SER H 127
SER H 128
 None
 0.84A 4ikkA-2xraH:
undetectable
4ikkB-2xraH:
undetectable		 4ikkA-2xraH:
22.83
4ikkB-2xraH:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.01A 6drzA-2xraH:
undetectable		 6drzA-2xraH:
17.99