SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xrc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 6 ILE A 300
ARG A 299
TYR A  67
PHE A  82
 None
 1.49A 1e73M-2xrcA:
undetectable		 1e73M-2xrcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.28A 1p6kA-2xrcA:
undetectable		 1p6kA-2xrcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.30A 1zzqA-2xrcA:
undetectable		 1zzqA-2xrcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.27A 1zzqB-2xrcA:
undetectable		 1zzqB-2xrcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.25A 1zzuA-2xrcA:
undetectable		 1zzuA-2xrcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 SER A 475
ASN A 446
GLN A 444
ASN A 476
 NAG  A 676 (-4.5A)
NAG  A 646 (-2.5A)
None
NAG  A 676 (-2.5A)
 1.23A 1zzuB-2xrcA:
undetectable		 1zzuB-2xrcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 ASP A 447
VAL A 471
PRO A 538
 None
 0.65A 2avvA-2xrcA:
undetectable		 2avvA-2xrcA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		5 / 12 TYR A 408
VAL A 526
TRP A 528
GLY A 539
TYR A 541
 None
 0.50A 2p16A-2xrcA:
22.1		 2p16A-2xrcA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		5 / 12 TYR A 408
VAL A 526
TRP A 528
GLY A 539
TYR A 541
 None
 0.39A 2w26A-2xrcA:
22.2		 2w26A-2xrcA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 6 ASP A 411
TYR A 408
TYR A 486
TYR A 547
 None
 1.23A 2w98A-2xrcA:
undetectable
2w98B-2xrcA:
undetectable		 2w98A-2xrcA:
20.62
2w98B-2xrcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 GLN A 143
ASP A 231
TYR A 216
SER A 233
 None
 1.25A 2xz5C-2xrcA:
undetectable
2xz5D-2xrcA:
undetectable		 2xz5C-2xrcA:
17.68
2xz5D-2xrcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 5 VAL A 522
VAL A 436
THR A 359
THR A 520
 None
 1.24A 3bjwG-2xrcA:
undetectable		 3bjwG-2xrcA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 5 VAL A 522
VAL A 436
THR A 359
THR A 520
 None
 1.22A 3bjwD-2xrcA:
undetectable		 3bjwD-2xrcA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 THR A 268
ASP A 271
GLU A 263
 None
CA  A 600 (-3.3A)
None
 0.85A 3qowA-2xrcA:
undetectable		 3qowA-2xrcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 PHE A  94
GLN A  70
PHE A 180
 None
 0.76A 3rv5A-2xrcA:
undetectable		 3rv5A-2xrcA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 6 ILE A 352
ILE A 267
TRP A 438
TRP A 523
 None
 1.26A 3welA-2xrcA:
undetectable		 3welA-2xrcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		5 / 12 GLY A 349
GLN A 336
VAL A 451
ILE A 412
VAL A 544
 None
 1.33A 4okwA-2xrcA:
undetectable		 4okwA-2xrcA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 6 LYS A 301
LEU A 304
PRO A  50
ARG A 169
 None
 1.40A 4yv5A-2xrcA:
undetectable		 4yv5A-2xrcA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		5 / 12 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5igyA-2xrcA:
undetectable		 5igyA-2xrcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		5 / 12 ILE A 339
GLY A 348
PHE A 399
ALA A 361
ILE A 352
 None
 1.04A 5ih0A-2xrcA:
undetectable		 5ih0A-2xrcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 8 ASN A 159
THR A 185
GLN A 189
GLY A 187
 NAG  A 659 (-1.9A)
None
None
None
 0.94A 5nzxA-2xrcA:
undetectable		 5nzxA-2xrcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		4 / 7 ASN A 159
THR A 185
GLN A 189
GLY A 187
 NAG  A 659 (-1.9A)
None
None
None
 0.92A 5nzyA-2xrcA:
undetectable		 5nzyA-2xrcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 THR A 268
GLU A 270
HIS A 247
 None
 0.87A 5xioA-2xrcA:
undetectable		 5xioA-2xrcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 THR A 268
GLU A 270
HIS A 247
 None
 0.87A 5xiqB-2xrcA:
undetectable		 5xiqB-2xrcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 THR A 268
GLU A 270
HIS A 247
 None
 0.86A 5xiqD-2xrcA:
undetectable		 5xiqD-2xrcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens) 		3 / 3 PHE A 191
ASP A 193
LYS A 124
 None
 0.62A 6awtD-2xrcA:
undetectable		 6awtD-2xrcA:
14.79