SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICR_A_NIOA604_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 5	SER A 207 THR A 187 GLU A 205 GLY A 204	None	1.05A	1icrA-2xrdA: undetectable 1icrB-2xrdA: undetectable	1icrA-2xrdA: 19.00 1icrB-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICR_B_NIOB602_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 5	GLU A 205 GLY A 204 SER A 207 THR A 187	None	1.07A	1icrA-2xrdA: undetectable 1icrB-2xrdA: undetectable	1icrA-2xrdA: 19.00 1icrB-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_A_NIOA221_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 6	SER A 207 THR A 187 GLU A 205 GLY A 204	None	1.07A	1icuA-2xrdA: undetectable 1icuB-2xrdA: undetectable	1icuA-2xrdA: 19.00 1icuB-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_B_NIOB219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 6	GLU A 205 GLY A 204 SER A 207 THR A 187	None	1.07A	1icuA-2xrdA: undetectable 1icuB-2xrdA: undetectable	1icuA-2xrdA: 19.00 1icuB-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_C_NIOC225_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 6	SER A 207 THR A 187 GLU A 205 GLY A 204	None	1.02A	1icuC-2xrdA: undetectable 1icuD-2xrdA: undetectable	1icuC-2xrdA: 19.00 1icuD-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICV_C_NIOC708_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 5	SER A 207 THR A 187 GLU A 205 GLY A 204	None	1.07A	1icvC-2xrdA: undetectable 1icvD-2xrdA: undetectable	1icvC-2xrdA: 19.00 1icvD-2xrdA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_C_BEZC522_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 6	SER A 207 THR A 187 GLU A 205 GLY A 204	None	1.07A	1kqbC-2xrdA: undetectable 1kqbD-2xrdA: undetectable	1kqbC-2xrdA: 21.33 1kqbD-2xrdA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA309_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	2xrd	COMPLEMENT REGULATORY PROTEIN CRRY (Rattus norvegicus)	4 / 4	LEU A 132 GLY A 134 SER A 135 SER A 137	None	1.32A	5uunA-2xrdA: undetectable	5uunA-2xrdA: 19.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICR_A_NIOA604_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"SER A 207;THR A 187;GLU A 205;GLY A 204","None","1.05A","1icrA-2xrdA:undetectable;1icrB-2xrdA:undetectable","1icrA-2xrdA:19.00;1icrB-2xrdA:19.00"],["1ICR_B_NIOB602_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"GLU A 205;GLY A 204;SER A 207;THR A 187","None","1.07A","1icrA-2xrdA:undetectable;1icrB-2xrdA:undetectable","1icrA-2xrdA:19.00;1icrB-2xrdA:19.00"],["1ICU_A_NIOA221_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"SER A 207;THR A 187;GLU A 205;GLY A 204","None","1.07A","1icuA-2xrdA:undetectable;1icuB-2xrdA:undetectable","1icuA-2xrdA:19.00;1icuB-2xrdA:19.00"],["1ICU_B_NIOB219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"GLU A 205;GLY A 204;SER A 207;THR A 187","None","1.07A","1icuA-2xrdA:undetectable;1icuB-2xrdA:undetectable","1icuA-2xrdA:19.00;1icuB-2xrdA:19.00"],["1ICU_C_NIOC225_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"SER A 207;THR A 187;GLU A 205;GLY A 204","None","1.02A","1icuC-2xrdA:undetectable;1icuD-2xrdA:undetectable","1icuC-2xrdA:19.00;1icuD-2xrdA:19.00"],["1ICV_C_NIOC708_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"SER A 207;THR A 187;GLU A 205;GLY A 204","None","1.07A","1icvC-2xrdA:undetectable;1icvD-2xrdA:undetectable","1icvC-2xrdA:19.00;1icvD-2xrdA:19.00"],["1KQB_C_BEZC522_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"SER A 207;THR A 187;GLU A 205;GLY A 204","None","1.07A","1kqbC-2xrdA:undetectable;1kqbD-2xrdA:undetectable","1kqbC-2xrdA:21.33;1kqbD-2xrdA:21.33"],["5UUN_A_ACTA309_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","2xrd","COMPLEMENT REGULATORY PROTEIN CRRY","Rattus norvegicus",4,"LEU A 132;GLY A 134;SER A 135;SER A 137","None","1.32A","5uunA-2xrdA:undetectable","5uunA-2xrdA:19.76"]]