SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		4 / 6 PRO A 169
PHE A 330
LEU A 275
ILE A 316
 None
 0.95A 1sbrA-2xriA:
undetectable
1sbrB-2xriA:
undetectable		 1sbrA-2xriA:
18.70
1sbrB-2xriA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		4 / 8 ALA A 153
ILE A 165
GLY A 309
HIS A 307
 GOL  A1338 (-3.9A)
None
MG  A1337 ( 4.3A)
None
 0.75A 1sv9A-2xriA:
undetectable		 1sv9A-2xriA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		4 / 7 TYR A 260
GLU A 222
SER A 216
VAL A 191
 None
 1.24A 1tv8B-2xriA:
undetectable		 1tv8B-2xriA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		5 / 8 ILE A 170
LEU A 149
PHE A 242
TYR A 268
LEU A 221
 None
 1.33A 2einA-2xriA:
undetectable
2einJ-2xriA:
undetectable		 2einA-2xriA:
17.13
2einJ-2xriA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		3 / 3 ARG A 223
GLN A 214
PRO A 215
 None
 0.86A 2qhfA-2xriA:
undetectable		 2qhfA-2xriA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		4 / 7 VAL A 224
VAL A 220
LEU A 217
SER A 216
 None
 0.86A 3hs6B-2xriA:
undetectable		 3hs6B-2xriA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		5 / 10 ILE A 316
ILE A 319
LEU A 300
HIS A 185
ILE A 310
 None
 1.32A 5vkqA-2xriA:
undetectable
5vkqD-2xriA:
undetectable		 5vkqA-2xriA:
7.88
5vkqD-2xriA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		5 / 10 HIS A 185
ILE A 310
ILE A 316
ILE A 319
LEU A 300
 None
 1.31A 5vkqA-2xriA:
undetectable
5vkqB-2xriA:
undetectable		 5vkqA-2xriA:
7.88
5vkqB-2xriA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2xri ERI1 EXORIBONUCLEASE
3
(Homo
sapiens) 		5 / 10 HIS A 185
ILE A 310
ILE A 316
ILE A 319
LEU A 300
 None
 1.31A 5vkqC-2xriA:
undetectable
5vkqD-2xriA:
undetectable		 5vkqC-2xriA:
7.88
5vkqD-2xriA:
7.88