SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 10 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 1.04A 1d4yA-2xrmA:
undetectable		 1d4yA-2xrmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 9 GLY A  87
ALA A 250
THR A  93
THR A 151
ALA A 253
 None
 1.35A 1gtnQ-2xrmA:
undetectable
1gtnR-2xrmA:
undetectable		 1gtnQ-2xrmA:
15.72
1gtnR-2xrmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.90A 1jnoA-2xrmA:
undetectable		 1jnoA-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.90A 1jnoB-2xrmA:
undetectable		 1jnoB-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.73A 1jo3A-2xrmA:
undetectable		 1jo3A-2xrmA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.73A 1jo3B-2xrmA:
undetectable		 1jo3B-2xrmA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.94A 1jo4A-2xrmA:
undetectable		 1jo4A-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.94A 1jo4B-2xrmA:
undetectable		 1jo4B-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 11 GLY A 102
SER A  19
GLY A  92
LEU A 112
ILE A  63
 NA  A 401 ( 4.7A)
None
None
None
None
 1.07A 1jzsA-2xrmA:
undetectable		 1jzsA-2xrmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.86A 1ng8A-2xrmA:
undetectable		 1ng8A-2xrmA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.86A 1ng8B-2xrmA:
undetectable		 1ng8B-2xrmA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.96A 1nrmA-2xrmA:
undetectable		 1nrmA-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.96A 1nrmB-2xrmA:
undetectable		 1nrmB-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.94A 1nruA-2xrmA:
undetectable		 1nruA-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		3 / 3 ALA A  96
VAL A 106
TRP A  34
 None
 0.94A 1nruB-2xrmA:
undetectable		 1nruB-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 11 THR A 151
VAL A  94
GLY A 258
ILE A 150
VAL A 178
 None
 1.19A 1phgA-2xrmA:
undetectable		 1phgA-2xrmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A 154
LEU A 118
GLY A 127
ALA A 130
ALA A 166
 None
 1.14A 2br4A-2xrmA:
undetectable		 2br4A-2xrmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A 154
LEU A 118
GLY A 127
ALA A 130
ALA A 166
 None
 1.15A 2br4E-2xrmA:
undetectable		 2br4E-2xrmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 LEU A 154
LEU A 118
GLY A 127
ALA A 130
ALA A 166
 None
 1.02A 2br4F-2xrmA:
undetectable		 2br4F-2xrmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 0.97A 2nnkB-2xrmA:
undetectable		 2nnkB-2xrmA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 11 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 1.09A 2o4pA-2xrmA:
undetectable		 2o4pA-2xrmA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 LEU A 163
VAL A 167
LYS A 168
ILE A 133
 None
 0.89A 2piwA-2xrmA:
undetectable		 2piwA-2xrmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		6 / 10 VAL A  25
GLY A  24
GLY A 258
LEU A 262
LEU A 305
ALA A  30
 None
 1.30A 2v3kA-2xrmA:
undetectable		 2v3kA-2xrmA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 GLY A 156
ALA A 195
LEU A 163
PRO A 197
 None
 0.85A 3bgdA-2xrmA:
undetectable		 3bgdA-2xrmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 9 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 1.05A 3ekyB-2xrmA:
undetectable		 3ekyB-2xrmA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 11 GLY A 299
PHE A 302
ALA A 288
ASP A 226
ILE A 227
 None
None
None
SR  A 403 ( 2.2A)
None
 1.38A 3id5B-2xrmA:
undetectable		 3id5B-2xrmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 11 GLY A 299
PHE A 302
ALA A 288
ASP A 226
ILE A 227
 None
None
None
SR  A 403 ( 2.2A)
None
 1.38A 3id5F-2xrmA:
undetectable		 3id5F-2xrmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 GLY A 299
ALA A 297
PHE A 302
ALA A 288
ILE A 227
 None
 1.03A 3id6C-2xrmA:
undetectable		 3id6C-2xrmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 10 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 0.96A 3lzvA-2xrmA:
undetectable		 3lzvA-2xrmA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 9 ASP A  49
ILE A 115
GLY A  46
ILE A 149
VAL A 167
 None
 1.05A 3ndwB-2xrmA:
undetectable		 3ndwB-2xrmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 GLY A  46
ALA A 136
ILE A 149
ALA A 257
VAL A  47
 None
 1.02A 3nvkI-2xrmA:
undetectable		 3nvkI-2xrmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ALA A 259
ILE A 263
LEU A 305
ALA A 229
 None
 0.90A 3r9sA-2xrmA:
3.2		 3r9sA-2xrmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ALA A 259
ILE A 263
LEU A 305
ALA A 229
 None
 0.87A 3r9sC-2xrmA:
4.1		 3r9sC-2xrmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 7 GLU A  98
THR A 237
LEU A 112
SER A 101
 None
None
None
NA  A 401 (-4.0A)
 1.13A 4pfjA-2xrmA:
4.8		 4pfjA-2xrmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 10 HIS A  86
LEU A 118
ALA A 181
ALA A 250
GLY A 155
 None
 1.24A 4rn6A-2xrmA:
undetectable		 4rn6A-2xrmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 10 HIS A  86
LEU A 118
ALA A 198
ALA A 250
GLY A 155
 None
 1.22A 4rn6A-2xrmA:
undetectable		 4rn6A-2xrmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ILE A 149
ARG A 148
ILE A 280
GLU A 277
 None
None
None
1PE  A 410 (-4.1A)
 1.36A 4zzcA-2xrmA:
undetectable
4zzcB-2xrmA:
undetectable		 4zzcA-2xrmA:
20.36
4zzcB-2xrmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ILE A 149
ARG A 148
ILE A 280
GLU A 277
 None
None
None
1PE  A 410 (-4.1A)
 1.32A 4zzcB-2xrmA:
undetectable
4zzcC-2xrmA:
undetectable		 4zzcB-2xrmA:
20.36
4zzcC-2xrmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 ALA A  60
PHE A 211
ILE A  27
GLY A 231
THR A  88
 None
 1.22A 5jlcA-2xrmA:
undetectable		 5jlcA-2xrmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 8 ALA A 229
VAL A 228
PHE A 293
THR A 289
 None
 1.00A 5v0vA-2xrmA:
undetectable		 5v0vA-2xrmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 8 PRO A 197
ALA A 253
THR A 151
ALA A 117
 None
 1.01A 5x2tI-2xrmA:
undetectable
5x2tJ-2xrmA:
undetectable
5x2tK-2xrmA:
undetectable
5x2tL-2xrmA:
undetectable		 5x2tI-2xrmA:
20.48
5x2tJ-2xrmA:
16.35
5x2tK-2xrmA:
20.48
5x2tL-2xrmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		5 / 12 HIS A 255
GLY A  24
VAL A 209
ILE A  45
GLY A 105
 None
 1.14A 6c2mA-2xrmA:
undetectable		 6c2mA-2xrmA:
14.92