SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		5 / 11 ALA A  26
ILE A  17
VAL A  43
LEU A  74
VAL A  63
 None
 1.18A 1rv7A-2xroA:
undetectable
1rv7B-2xroA:
undetectable		 1rv7A-2xroA:
17.89
1rv7B-2xroA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		5 / 9 SER A 219
ALA A 221
THR A 145
VAL A 120
VAL A 223
 None
 1.05A 1td2B-2xroA:
undetectable		 1td2B-2xroA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 8 ALA A  20
ALA A  56
LEU A  74
VAL A  63
 None
 0.89A 2bxgA-2xroA:
undetectable		 2bxgA-2xroA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		5 / 10 ALA A 101
LEU A 211
LEU A 110
LEU A  97
LEU A 220
 None
 1.20A 2riwA-2xroA:
undetectable
2riwB-2xroA:
undetectable		 2riwA-2xroA:
23.86
2riwB-2xroA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		3 / 3 MET A 224
VAL A 140
GLU A 199
 None
 0.87A 2x9gA-2xroA:
undetectable		 2x9gA-2xroA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 6 GLN A 184
ALA A 142
ALA A 144
THR A 175
 None
 0.99A 2xfhA-2xroA:
undetectable		 2xfhA-2xroA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		5 / 12 ILE A  53
ILE A  54
LEU A  57
ALA A  26
VAL A  63
 None
 1.00A 3rukB-2xroA:
undetectable		 3rukB-2xroA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 6 LYS A 244
ILE A 247
VAL A  93
LEU A  97
 None
 0.67A 4em2A-2xroA:
7.9		 4em2A-2xroA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		5 / 12 ILE A  53
ILE A  54
LEU A  57
ALA A  26
VAL A  63
 None
 0.99A 4nkvB-2xroA:
undetectable		 4nkvB-2xroA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 6 VAL A 140
VAL A 223
SER A 109
ILE A 124
 None
 1.09A 5jw1B-2xroA:
undetectable		 5jw1B-2xroA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 6 PHE A  72
LEU A  57
ARG A  73
GLY A  75
 None
 0.95A 5o4yA-2xroA:
undetectable		 5o4yA-2xroA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV
(Pseudomonas
putida) 		4 / 6 PHE A  72
LEU A  57
ARG A  73
GLY A  75
 None
 0.86A 5o4yF-2xroA:
undetectable		 5o4yF-2xroA:
3.32