SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 PHE A  39
SER A   1
ALA A  42
ILE A  43
 None
 0.95A 1fxhA-2xryA:
undetectable
1fxhB-2xryA:
undetectable		 1fxhA-2xryA:
17.15
1fxhB-2xryA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 PHE A  39
SER A   1
ALA A  42
ILE A  43
 None
 0.89A 1pnlA-2xryA:
undetectable
1pnlB-2xryA:
undetectable		 1pnlA-2xryA:
17.15
1pnlB-2xryA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 LEU A 120
PRO A 413
GLY A 274
ASP A  28
 GOL  A1473 ( 4.0A)
None
None
None
 1.06A 2ddwB-2xryA:
undetectable		 2ddwB-2xryA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 PHE A 225
ILE A 400
ALA A 399
GLY A 371
LEU A 367
 None
 1.14A 2v0mB-2xryA:
undetectable		 2v0mB-2xryA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 PHE A 225
ILE A 419
ALA A 382
GLY A 371
LEU A 367
 None
FAD  A1463 ( 4.7A)
FAD  A1463 (-3.5A)
None
None
 1.07A 2v0mB-2xryA:
undetectable		 2v0mB-2xryA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 LEU A 396
PRO A 392
LEU A 386
LEU A 333
ALA A 329
 None
 1.13A 2vcvD-2xryA:
undetectable		 2vcvD-2xryA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 LEU A 396
PRO A 392
LEU A 386
LEU A 333
ALA A 329
 None
 1.17A 2vcvH-2xryA:
undetectable		 2vcvH-2xryA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 LEU A 396
PRO A 392
LEU A 386
LEU A 333
ALA A 329
 None
 1.09A 2vcvI-2xryA:
undetectable		 2vcvI-2xryA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 SER A 268
PHE A 230
VAL A 240
ASN A 262
 FAD  A1463 (-3.3A)
None
None
None
 1.13A 2wekA-2xryA:
2.2		 2wekA-2xryA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 SER A 268
PHE A 230
VAL A 240
ASN A 262
 FAD  A1463 (-3.3A)
None
None
None
 1.11A 2wekB-2xryA:
2.3		 2wekB-2xryA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRZ_A_ACTA1468_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 5 LYS A 383
LYS A 384
GLU A 387
THR A 437
TYR A 442
 None
 0.55A 2xrzA-2xryA:
61.7		 2xrzA-2xryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRZ_A_ACTA1469_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 4 GLN A  77
GLU A  80
LEU A 200
SER A 201
 SO4  A1467 (-4.2A)
SO4  A1467 (-2.8A)
SO4  A1467 (-3.9A)
SO4  A1467 (-2.7A)
 0.40A 2xrzA-2xryA:
61.7		 2xrzA-2xryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 5 ARG A 256
ALA A 297
ASP A 300
GLU A 301
TRP A 305
 None
None
None
FAD  A1463 (-3.9A)
GOL  A1474 ( 3.4A)
 0.37A 2xrzA-2xryA:
61.7		 2xrzA-2xryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		7 / 7 GLN A  16
VAL A  21
ILE A  43
ALA A  47
VAL A  49
GLY A 111
THR A 112
 None
 0.26A 2xrzB-2xryA:
59.6		 2xrzB-2xryA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRZ_B_ACTB1464_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 4 LYS A 383
GLU A 387
THR A 437
TYR A 442
 None
 0.41A 2xrzB-2xryA:
59.6		 2xrzB-2xryA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 SER A 389
GLY A 321
GLU A 393
ILE A 400
 None
 0.84A 3aodA-2xryA:
undetectable		 3aodA-2xryA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 10 LEU A  38
ALA A 143
ASP A 116
GLY A 274
ILE A 276
 None
 1.16A 3el5A-2xryA:
undetectable		 3el5A-2xryA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 12 MET A   3
ILE A   8
LEU A  38
VAL A  53
ARG A  30
 None
 1.20A 3fpjB-2xryA:
undetectable		 3fpjB-2xryA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 MET A 373
LEU A 367
SER A 268
GLY A 418
 None
None
FAD  A1463 (-3.3A)
GOL  A1474 (-3.6A)
 1.05A 3hcnA-2xryA:
2.9		 3hcnA-2xryA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		3 / 3 TYR A 376
LEU A 299
LYS A 296
 None
 0.78A 3sueD-2xryA:
undetectable		 3sueD-2xryA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 12 PRO A 392
LEU A 386
ILE A 440
ALA A 335
SER A 332
 None
 1.34A 4a83A-2xryA:
undetectable		 4a83A-2xryA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.20A 4feuF-2xryA:
undetectable		 4feuF-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.21A 4fevD-2xryA:
undetectable		 4fevD-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.22A 4fevF-2xryA:
undetectable		 4fevF-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.20A 4fewD-2xryA:
undetectable		 4fewD-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 7 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.21A 4gkhG-2xryA:
undetectable		 4gkhG-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 6 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.29A 4gkhJ-2xryA:
undetectable		 4gkhJ-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 6 ASP A 116
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.34A 4gkhJ-2xryA:
undetectable		 4gkhJ-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		4 / 8 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.21A 4gkiC-2xryA:
undetectable		 4gkiC-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 12 THR A 377
THR A 370
ASN A 266
HIS A 374
TYR A 457
 None
None
FAD  A1463 (-4.6A)
None
None
 1.36A 4s0vA-2xryA:
undetectable		 4s0vA-2xryA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		3 / 3 GLY A 410
ASP A 409
ASN A 266
 FAD  A1463 (-3.4A)
FAD  A1463 (-3.4A)
FAD  A1463 (-4.6A)
 0.57A 5jglA-2xryA:
2.3		 5jglA-2xryA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 12 SER A  40
TRP A  24
VAL A 141
PHE A 138
LEU A 113
 None
 1.46A 5jo9A-2xryA:
2.5		 5jo9A-2xryA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 VAL A 105
LEU A 113
PHE A 138
VAL A 130
ILE A 101
 None
 1.20A 5om2A-2xryA:
undetectable
5om2B-2xryA:
undetectable		 5om2A-2xryA:
13.97
5om2B-2xryA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Methanosarcina
mazei) 		5 / 9 GLN A  29
LEU A  83
SER A  82
GLU A  78
LEU A  76
 None
 1.31A 6ftpA-2xryA:
undetectable
6ftpB-2xryA:
undetectable		 6ftpA-2xryA:
13.97
6ftpB-2xryA:
6.52