SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICR_A_NIOA604_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	SER A 86 THR A 41 PHE A 84 GLU A 68	None U C 4 ( 4.3A) U C 4 ( 3.6A) None	1.23A	1icrA-2xs5A: undetectable 1icrB-2xs5A: undetectable	1icrA-2xs5A: 19.54 1icrB-2xs5A: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICR_B_NIOB602_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	GLU A 68 SER A 86 THR A 41 PHE A 84	None None U C 4 ( 4.3A) U C 4 ( 3.6A)	1.26A	1icrA-2xs5A: undetectable 1icrB-2xs5A: undetectable	1icrA-2xs5A: 19.54 1icrB-2xs5A: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICV_C_NIOC708_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	SER A 86 THR A 41 PHE A 84 GLU A 68	None U C 4 ( 4.3A) U C 4 ( 3.6A) None	1.26A	1icvC-2xs5A: undetectable 1icvD-2xs5A: undetectable	1icvC-2xs5A: 19.54 1icvD-2xs5A: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICV_D_NIOD706_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	GLU A 68 SER A 86 THR A 41 PHE A 84	None None U C 4 ( 4.3A) U C 4 ( 3.6A)	1.26A	1icvC-2xs5A: undetectable 1icvD-2xs5A: undetectable	1icvC-2xs5A: 19.54 1icvD-2xs5A: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_B_BEZB525_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	GLU A 68 SER A 86 THR A 41 PHE A 84	None None U C 4 ( 4.3A) U C 4 ( 3.6A)	1.18A	1kqbA-2xs5A: undetectable 1kqbB-2xs5A: undetectable	1kqbA-2xs5A: 18.86 1kqbB-2xs5A: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_B_BEZB525_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 5	GLY A 83 SER A 86 THR A 41 PHE A 84	None None U C 4 ( 4.3A) U C 4 ( 3.6A)	1.20A	1kqbA-2xs5A: undetectable 1kqbB-2xs5A: undetectable	1kqbA-2xs5A: 18.86 1kqbB-2xs5A: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_A_CCSA417_0 (ESTROGEN RECEPTOR)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	3 / 3	GLU A 53 LYS A 70 VAL A 69	C D 5 ( 4.2A) U C 4 ( 2.6A) None	0.96A	1l2iA-2xs5A: undetectable	1l2iA-2xs5A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ACTA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2xs5	DELETED IN AZOOSPERMIA-LIKE (Mus musculus)	4 / 6	PHE A 60 VAL A 85 MET A 51 ILE A 47	None	1.22A	5iwuA-2xs5A: undetectable	5iwuA-2xs5A: 12.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICR_A_NIOA604_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"SER A  86;THR A  41;PHE A  84;GLU A  68","None;  U C   4 ( 4.3A);  U C   4 ( 3.6A);None","1.23A","1icrA-2xs5A:undetectable;1icrB-2xs5A:undetectable","1icrA-2xs5A:19.54;1icrB-2xs5A:19.54"],["1ICR_B_NIOB602_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"GLU A  68;SER A  86;THR A  41;PHE A  84","None;None;  U C   4 ( 4.3A);  U C   4 ( 3.6A)","1.26A","1icrA-2xs5A:undetectable;1icrB-2xs5A:undetectable","1icrA-2xs5A:19.54;1icrB-2xs5A:19.54"],["1ICV_C_NIOC708_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"SER A  86;THR A  41;PHE A  84;GLU A  68","None;  U C   4 ( 4.3A);  U C   4 ( 3.6A);None","1.26A","1icvC-2xs5A:undetectable;1icvD-2xs5A:undetectable","1icvC-2xs5A:19.54;1icvD-2xs5A:19.54"],["1ICV_D_NIOD706_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"GLU A  68;SER A  86;THR A  41;PHE A  84","None;None;  U C   4 ( 4.3A);  U C   4 ( 3.6A)","1.26A","1icvC-2xs5A:undetectable;1icvD-2xs5A:undetectable","1icvC-2xs5A:19.54;1icvD-2xs5A:19.54"],["1KQB_B_BEZB525_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"GLU A  68;SER A  86;THR A  41;PHE A  84","None;None;  U C   4 ( 4.3A);  U C   4 ( 3.6A)","1.18A","1kqbA-2xs5A:undetectable;1kqbB-2xs5A:undetectable","1kqbA-2xs5A:18.86;1kqbB-2xs5A:18.86"],["1KQB_B_BEZB525_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"GLY A  83;SER A  86;THR A  41;PHE A  84","None;None;  U C   4 ( 4.3A);  U C   4 ( 3.6A)","1.20A","1kqbA-2xs5A:undetectable;1kqbB-2xs5A:undetectable","1kqbA-2xs5A:18.86;1kqbB-2xs5A:18.86"],["1L2I_A_CCSA417_0","ESTROGEN RECEPTOR","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",3,"GLU A  53;LYS A  70;VAL A  69","  C D   5 ( 4.2A);  U C   4 ( 2.6A);None","0.96A","1l2iA-2xs5A:undetectable","1l2iA-2xs5A:17.27"],["5IWU_A_ACTA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","2xs5","DELETED IN AZOOSPERMIA-LIKE","Mus musculus",4,"PHE A  60;VAL A  85;MET A  51;ILE A  47","None","1.22A","5iwuA-2xs5A:undetectable","5iwuA-2xs5A:12.29"]]