SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		4 / 8 LEU A 111
LEU A 181
LEU A 255
THR A 187
 None
 0.98A 1dvtA-2xs6A:
undetectable
1dvtB-2xs6A:
undetectable		 1dvtA-2xs6A:
21.46
1dvtB-2xs6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		4 / 4 LEU A 131
VAL A 132
ILE A 135
TRP A 165
 None
 1.47A 1s9qB-2xs6A:
undetectable		 1s9qB-2xs6A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		4 / 7 LEU A 185
LEU A 181
LEU A 214
PRO A 115
 None
None
None
CL  A1295 ( 4.3A)
 0.91A 2vq5B-2xs6A:
undetectable		 2vq5B-2xs6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		5 / 12 LEU A 246
THR A 249
GLU A 136
LEU A 225
ILE A 174
 None
 1.44A 2ydoA-2xs6A:
undetectable		 2ydoA-2xs6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		3 / 3 HIS A 145
HIS A 228
ILE A 174
 None
 0.70A 3u52A-2xs6A:
undetectable
3u52C-2xs6A:
undetectable		 3u52A-2xs6A:
13.70
3u52C-2xs6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		4 / 4 VAL A 232
GLU A 136
GLY A 230
LEU A 229
 None
 1.37A 5g5gC-2xs6A:
undetectable		 5g5gC-2xs6A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2xs6 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens) 		4 / 8 THR A 138
GLY A 139
LEU A 170
ALA A 168
 None
 0.72A 5vw5A-2xs6A:
undetectable		 5vw5A-2xs6A:
21.25