SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 PHE A 155
TYR A 174
PRO A 157
 None
 1.11A 1mcnA-2xsbA:
undetectable
1mcnB-2xsbA:
undetectable
1mcnP-2xsbA:
undetectable		 1mcnA-2xsbA:
17.11
1mcnB-2xsbA:
17.11
1mcnP-2xsbA:
0.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 11 ARG A 177
LEU A 178
ILE A 188
ARG A 213
GLY A 209
 None
 1.09A 2bxmA-2xsbA:
2.7		 2bxmA-2xsbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 ARG A 177
LEU A 178
ILE A 188
ARG A 213
GLY A 209
 None
 1.17A 2bxqA-2xsbA:
2.5		 2bxqA-2xsbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 7 GLY A 239
GLY A 238
ASP A 220
VAL A 201
 None
 0.83A 2oa1B-2xsbA:
undetectable		 2oa1B-2xsbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		9 / 11 ASP A 115
CYH A 156
TYR A 160
THR A 191
TRP A 219
ASN A 221
ASP A 226
TYR A 227
ASN A 254
 None
GDL  A1436 ( 3.9A)
GDL  A1436 (-3.6A)
GDL  A1436 ( 4.5A)
GDL  A1436 (-3.6A)
GDL  A1436 (-3.0A)
GDL  A1436 (-3.0A)
GDL  A1436 (-4.8A)
GDL  A1436 (-3.4A)
 0.49A 2w4xA-2xsbA:
31.3		 2w4xA-2xsbA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		8 / 12 LYS A  39
ASP A 115
TYR A 160
THR A 191
TRP A 219
ASN A 221
ASP A 226
ASN A 254
 GDL  A1436 ( 3.8A)
None
GDL  A1436 (-3.6A)
GDL  A1436 ( 4.5A)
GDL  A1436 (-3.6A)
GDL  A1436 (-3.0A)
GDL  A1436 (-3.0A)
GDL  A1436 (-3.4A)
 0.42A 2x0yA-2xsbA:
38.6		 2x0yA-2xsbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		9 / 12 LYS A  39
ASP A 115
TYR A 160
THR A 191
TRP A 219
ASN A 221
ASP A 226
TYR A 227
ASN A 254
 GDL  A1436 ( 3.8A)
None
GDL  A1436 (-3.6A)
GDL  A1436 ( 4.5A)
GDL  A1436 (-3.6A)
GDL  A1436 (-3.0A)
GDL  A1436 (-3.0A)
GDL  A1436 (-4.8A)
GDL  A1436 (-3.4A)
 0.52A 2x0yB-2xsbA:
39.7		 2x0yB-2xsbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 MET A  23
GLU A   7
ASP A  41
 None
 0.79A 3a25A-2xsbA:
undetectable		 3a25A-2xsbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 8 LEU A 182
ILE A 188
ARG A 213
GLY A 209
 None
 0.87A 3b9lA-2xsbA:
2.6		 3b9lA-2xsbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 8 PHE A 189
VAL A 248
LEU A 205
PRO A 216
 None
 0.77A 3bgdB-2xsbA:
undetectable		 3bgdB-2xsbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 7 LEU A 237
TYR A 272
VAL A  73
ILE A  26
 None
 1.14A 3ik3A-2xsbA:
undetectable		 3ik3A-2xsbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 7 LEU A 237
TYR A 272
VAL A  73
ILE A  26
 None
 1.19A 3ik3B-2xsbA:
undetectable		 3ik3B-2xsbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 9 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.19A 3p4wB-2xsbA:
4.1		 3p4wB-2xsbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.17A 3p4wD-2xsbA:
3.6		 3p4wD-2xsbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.20A 3p4wE-2xsbA:
2.7		 3p4wE-2xsbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PHE A 382
ASN A 256
ALA A 265
THR A 268
ILE A 284
 None
 1.29A 3t3qA-2xsbA:
undetectable		 3t3qA-2xsbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PHE A 382
ASN A 256
ALA A 265
THR A 268
ILE A 284
 None
 1.31A 3t3qB-2xsbA:
undetectable		 3t3qB-2xsbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PHE A 382
ASN A 256
ALA A 265
THR A 268
ILE A 284
 None
 1.32A 3t3qC-2xsbA:
undetectable		 3t3qC-2xsbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PHE A 382
ASN A 256
ALA A 265
THR A 268
ILE A 284
 None
 1.29A 3t3qD-2xsbA:
undetectable		 3t3qD-2xsbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 8 TRP A 349
ARG A 350
LEU A 353
ARG A 357
 None
 0.67A 3zmdA-2xsbA:
undetectable
3zmdB-2xsbA:
undetectable		 3zmdA-2xsbA:
17.34
3zmdB-2xsbA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 12 LEU A 245
TRP A 251
ASP A 220
VAL A 196
PHE A 320
 None
 1.45A 4amjB-2xsbA:
undetectable		 4amjB-2xsbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 7 ASN A 262
GLU A   7
GLU A  18
ARG A  19
 None
 1.06A 4mi4B-2xsbA:
undetectable
4mi4C-2xsbA:
undetectable		 4mi4B-2xsbA:
18.47
4mi4C-2xsbA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 8 ASN A 262
GLU A   7
GLU A  18
ARG A  19
 None
 1.05A 4mj8B-2xsbA:
undetectable
4mj8C-2xsbA:
undetectable		 4mj8B-2xsbA:
17.57
4mj8C-2xsbA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 12 ILE A 329
ALA A 430
LEU A 356
LEU A 396
PHE A 427
 None
 1.26A 4pbhA-2xsbA:
undetectable		 4pbhA-2xsbA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 ARG A  16
ASP A  17
ARG A  15
 None
 0.57A 4wq4B-2xsbA:
1.9		 4wq4B-2xsbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 4 CYH A 400
LEU A 333
LEU A 353
ALA A 352
 None
 1.06A 5hpuA-2xsbA:
undetectable
5hpuB-2xsbA:
undetectable		 5hpuA-2xsbA:
4.27
5hpuB-2xsbA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 7 ILE A 266
ILE A  26
MET A  31
THR A 253
ILE A 252
 None
 1.43A 5murB-2xsbA:
3.4		 5murB-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 7 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.14A 5murB-2xsbA:
3.4		 5murB-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.15A 5mzrA-2xsbA:
4.1		 5mzrA-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 ILE A 266
ILE A  26
MET A  31
THR A 253
ILE A 252
 None
 1.34A 5mzrC-2xsbA:
3.7		 5mzrC-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 10 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.13A 5mzrC-2xsbA:
3.7		 5mzrC-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 9 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.14A 5mzrD-2xsbA:
3.7		 5mzrD-2xsbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		5 / 6 ASN A 225
ALA A 224
PRO A 319
ASP A 226
TYR A 227
 None
GDL  A1436 ( 3.9A)
None
GDL  A1436 (-3.0A)
GDL  A1436 (-4.8A)
 1.46A 5umd2-2xsbA:
undetectable
5umdF-2xsbA:
undetectable		 5umd2-2xsbA:
9.01
5umdF-2xsbA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 ILE A  26
VAL A   5
PRO A 255
 None
 0.68A 5uunA-2xsbA:
undetectable		 5uunA-2xsbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		4 / 8 HIS A 223
HIS A 267
TRP A  25
TRP A 291
 None
 1.23A 5yj1k-2xsbA:
undetectable
5yj1t-2xsbA:
undetectable		 5yj1k-2xsbA:
14.29
5yj1t-2xsbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 LYS A  39
LEU A  82
ASP A 115
 GDL  A1436 ( 3.8A)
None
None
 0.83A 5zv2A-2xsbA:
undetectable		 5zv2A-2xsbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2xsb HYALURONOGLUCOSAMINI
DASE
(Oceanicola
granulosus) 		3 / 3 ARG A 362
ARG A 361
ASP A 358
 None
 0.91A 6d8pA-2xsbA:
2.4		 6d8pA-2xsbA:
20.52