SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		4 / 7 GLY C  89
ILE C  80
TYR C  81
GLY A  77
 None
 0.84A 11gsB-2xsjC:
undetectable		 11gsB-2xsjC:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 LEU B 108
ALA B 111
LYS B 112
LYS B 115
 None
 0.42A 1e7cA-2xsjB:
undetectable		 1e7cA-2xsjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		4 / 7 ASP C  14
GLY A  69
GLY A  68
TYR A  84
 None
 0.96A 1ekjE-2xsjC:
undetectable
1ekjF-2xsjC:
undetectable		 1ekjE-2xsjC:
18.47
1ekjF-2xsjC:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 LEU A 115
LEU A 118
CYH A 119
LEU A 121
VAL A 100
 None
 1.05A 1s9pC-2xsjA:
undetectable		 1s9pC-2xsjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		4 / 5 ILE C  39
LEU C  50
ALA C  30
GLU C  31
 None
 1.00A 1xvaA-2xsjC:
undetectable
1xvaB-2xsjC:
undetectable		 1xvaA-2xsjC:
18.43
1xvaB-2xsjC:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		4 / 6 ALA C  30
GLU C  31
ILE C  39
LEU C  50
 None
 1.01A 1xvaA-2xsjC:
undetectable
1xvaB-2xsjC:
undetectable		 1xvaA-2xsjC:
18.43
1xvaB-2xsjC:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		4 / 7 PRO C  64
GLY C  87
LEU C  53
PRO C 101
 None
 0.93A 1ya4B-2xsjC:
undetectable		 1ya4B-2xsjC:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 8 LEU A 388
VAL A 400
LEU A 397
VAL A 395
VAL A 329
 None
 1.32A 2bdmA-2xsjA:
undetectable		 2bdmA-2xsjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 6 LEU A 205
ASN A 170
LYS A 215
ASP A 233
 None
None
SRM  B 503 ( 2.6A)
None
 1.31A 2w98A-2xsjA:
undetectable
2w98B-2xsjA:
undetectable		 2w98A-2xsjA:
20.70
2w98B-2xsjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 10 MET A 341
ALA A 331
HIS B 197
GLY A 342
ILE A 229
 None
 1.28A 2zm7A-2xsjA:
0.0		 2zm7A-2xsjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 10 MET A 341
ALA A 331
HIS B 197
GLY A 342
ILE A 229
 None
 1.28A 2zm8A-2xsjA:
0.0		 2zm8A-2xsjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		3 / 3 GLY B 174
GLY B  50
GLY B 133
 None
 0.39A 3bogC-2xsjB:
undetectable		 3bogC-2xsjB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		3 / 3 CYH A  85
HIS A  64
PHE A  91
 None
 1.13A 3cr4X-2xsjA:
undetectable		 3cr4X-2xsjA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 ARG A 231
GLY A 134
ALA A 175
THR A 173
LEU A 205
 SRM  B 503 (-4.0A)
SRM  B 503 (-3.3A)
None
None
None
 1.12A 3dh0B-2xsjA:
undetectable		 3dh0B-2xsjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 LEU A 121
MET A 132
ILE B  21
ASP B  28
 None
 1.46A 3hecA-2xsjA:
1.5		 3hecA-2xsjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 GLY A 220
GLY A 238
PHE A 218
SER A 176
ALA A 186
 SF4  A 502 (-3.5A)
None
None
None
SF4  A 502 (-3.8A)
 1.14A 3kkzA-2xsjA:
undetectable		 3kkzA-2xsjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		6 / 12 VAL A 226
GLY A 220
ARG A 323
ILE A 358
TYR A 355
LEU A 193
 None
SF4  A 502 (-3.5A)
None
None
None
None
 1.44A 3mb5A-2xsjA:
undetectable		 3mb5A-2xsjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 ASP A 233
VAL A 329
GLY A 364
VAL A 346
 None
 0.70A 3nu9A-2xsjA:
undetectable		 3nu9A-2xsjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 10 ALA B 290
ASP B 200
ILE B 184
VAL B 324
ILE B 328
 None
 1.06A 3oxvB-2xsjB:
undetectable		 3oxvB-2xsjB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		5 / 12 LEU C  69
GLY C  87
ALA C  92
ALA C  96
LEU C  50
 None
 1.15A 3p5nA-2xsjC:
undetectable		 3p5nA-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		5 / 12 LEU C  69
GLY C  89
ALA C  92
ALA C  96
LEU C  50
 None
 1.14A 3p5nA-2xsjC:
undetectable		 3p5nA-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		5 / 12 LEU C  69
GLY C  87
ALA C  92
ALA C  96
LEU C  50
 None
 1.16A 3p5nB-2xsjC:
undetectable		 3p5nB-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum) 		5 / 12 LEU C  69
GLY C  89
ALA C  92
ALA C  96
LEU C  50
 None
 1.14A 3p5nB-2xsjC:
undetectable		 3p5nB-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 5 GLU A 377
LEU A 379
GLN A 340
GLY A 330
 None
 1.29A 3pp1A-2xsjA:
2.0		 3pp1A-2xsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 GLY B  50
ILE B  46
GLY B 174
PHE B 173
MET B 176
 None
 1.40A 3ps9A-2xsjB:
undetectable		 3ps9A-2xsjB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		5 / 12 VAL A 102
ALA A 103
ALA B  26
LEU A 118
TYR A 110
 None
 1.19A 3qxyA-2xsjA:
undetectable		 3qxyA-2xsjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		5 / 11 VAL A 102
ALA A 103
ALA B  26
LEU A 118
TYR A 110
 None
 1.19A 3rc0A-2xsjA:
undetectable		 3rc0A-2xsjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		5 / 12 VAL A 102
ALA A 103
ALA B  26
LEU A 118
TYR A 110
 None
 1.17A 3rc0B-2xsjA:
undetectable		 3rc0B-2xsjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 9 GLY B 291
GLY B 350
ILE B 349
LEU B 360
VAL B 307
 None
 1.02A 3u7sB-2xsjB:
undetectable		 3u7sB-2xsjB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 TRP B 148
VAL B 149
PHE A  20
TRP B 318
 None
 1.14A 3v35A-2xsjB:
undetectable		 3v35A-2xsjB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		3 / 3 ASP A 233
ARG A 172
LYS A 215
 None
SO3  B 504 (-3.0A)
SRM  B 503 ( 2.6A)
 1.13A 3wipG-2xsjA:
undetectable		 3wipG-2xsjA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 7 VAL B 342
PHE B 354
VAL B 307
ILE B 184
 None
 0.98A 3zjqA-2xsjB:
undetectable		 3zjqA-2xsjB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		3 / 3 TYR A  76
HIS A 206
ARG A 207
 None
 0.98A 4e7bC-2xsjA:
undetectable		 4e7bC-2xsjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 11 HIS A  98
ILE A  81
GLY A 165
GLY A 166
ASN A 170
 None
SRM  B 503 ( 4.1A)
None
None
None
 1.26A 4fglA-2xsjA:
2.3
4fglB-2xsjA:
2.4		 4fglA-2xsjA:
18.95
4fglB-2xsjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 501 (-2.2A)
SF4  A 501 ( 4.2A)
None
 0.72A 4fo4A-2xsjA:
undetectable		 4fo4A-2xsjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 501 (-2.2A)
SF4  A 501 ( 4.2A)
None
 0.73A 4fo4B-2xsjA:
undetectable		 4fo4B-2xsjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 SER A 169
TYR A 212
ALA A 333
ASP A 233
GLY A 168
 None
SRM  B 503 (-4.6A)
SRM  B 503 (-3.6A)
None
None
 1.17A 4iilA-2xsjA:
undetectable		 4iilA-2xsjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 GLU A  26
MET B  73
ARG A  30
ILE B 101
GLY B  69
 None
 1.23A 4j26A-2xsjA:
undetectable		 4j26A-2xsjA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 PHE A  91
HIS A  64
GLY A  52
ILE A  53
 None
 1.41A 4k50E-2xsjA:
undetectable		 4k50E-2xsjA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 PHE A  91
HIS A  64
GLY A  52
ILE A  53
 None
 1.42A 4k50M-2xsjA:
0.0		 4k50M-2xsjA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 7 GLU B 168
GLU B 172
GLU B 330
ARG B 177
 None
 1.11A 4mi4B-2xsjB:
undetectable
4mi4C-2xsjB:
undetectable		 4mi4B-2xsjB:
17.39
4mi4C-2xsjB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 GLU B 168
GLU B 172
GLU B 330
ARG B 177
 None
 1.08A 4mj8B-2xsjB:
undetectable
4mj8C-2xsjB:
undetectable		 4mj8B-2xsjB:
16.41
4mj8C-2xsjB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 6 VAL B 182
ASP B 200
ALA B 346
PHE B 354
 None
 1.24A 4nedA-2xsjB:
undetectable		 4nedA-2xsjB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 ASP A 163
THR A 198
GLN A 202
LEU A 205
THR A 173
 None
 1.08A 4ng6A-2xsjA:
undetectable		 4ng6A-2xsjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 VAL B 162
LEU B 166
GLY B  69
ALA B  70
LEU B  72
 None
 0.95A 4o1zA-2xsjB:
undetectable		 4o1zA-2xsjB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 6 LEU A 141
MET A 160
LEU A 121
VAL A  38
 None
 1.15A 4okbA-2xsjA:
undetectable		 4okbA-2xsjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 7 GLU B 330
GLU B 168
GLU B 172
GLU B 171
 None
 1.27A 4r87I-2xsjB:
undetectable		 4r87I-2xsjB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 THR B  64
THR B 135
GLN B 181
THR B  96
CYH A 225
 None
SRM  A 503 (-4.2A)
None
SRM  A 503 (-2.8A)
SF4  A 502 ( 2.2A)
 1.42A 5d0xH-2xsjB:
undetectable
5d0xI-2xsjB:
undetectable		 5d0xH-2xsjB:
21.48
5d0xI-2xsjB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 GLY A  77
ASP B  20
HIS A 206
LEU A 164
TYR A 153
 None
 1.35A 5eeiB-2xsjA:
undetectable		 5eeiB-2xsjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		4 / 6 TYR A 254
LYS B 338
TYR B 339
GLY A 263
 None
 1.24A 5emlA-2xsjA:
undetectable		 5emlA-2xsjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 5 GLY A 330
ASP A 233
ARG A 378
MET B 289
 None
None
SRM  B 503 (-2.9A)
None
 1.08A 5gwkA-2xsjA:
2.0		 5gwkA-2xsjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 5 GLY A 143
THR A 144
GLY B 125
LEU A  51
 None
 0.71A 5jlcA-2xsjA:
undetectable		 5jlcA-2xsjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		3 / 3 LYS A 278
ASP A 282
ARG B 337
 None
 0.77A 5jwaA-2xsjA:
undetectable
5jwaH-2xsjA:
undetectable		 5jwaA-2xsjA:
18.45
5jwaH-2xsjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 9 ALA B 290
ASP B 200
ILE B 184
VAL B 324
ILE B 328
 None
 1.10A 5kr0A-2xsjB:
undetectable		 5kr0A-2xsjB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 5 ALA B 346
VAL B 342
LYS B 305
ILE B 201
 None
 0.92A 5of1A-2xsjB:
undetectable		 5of1A-2xsjB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 9 VAL A 351
LEU A 193
ALA A 190
PHE A 218
ILE A 358
 None
 1.08A 5om2A-2xsjA:
undetectable
5om2B-2xsjA:
undetectable		 5om2A-2xsjA:
11.21
5om2B-2xsjA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SRM  A 503 (-2.7A)
 1.38A 5tzoA-2xsjB:
undetectable		 5tzoA-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SRM  A 503 (-2.7A)
 1.39A 5tzoB-2xsjB:
undetectable		 5tzoB-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2xsj SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SRM  A 503 (-2.7A)
 1.36A 5tzoC-2xsjB:
undetectable		 5tzoC-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY
(Desulfomicrobium
norvegicum;
Desulfomicrobium
norvegicum) 		5 / 7 GLY A  78
GLY A  77
GLY C  87
GLY C  91
GLY C  89
 None
 1.01A 6ag0A-2xsjA:
undetectable		 6ag0A-2xsjA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 LEU A   9
ASP A  10
GLN A  13
VAL A 140
 None
 1.47A 6bzoF-2xsjA:
undetectable		 6bzoF-2xsjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT
(Desulfomicrobium
norvegicum) 		5 / 12 GLY A 166
GLY A 165
VAL A 102
ASN A 162
GLY B  22
 None
 1.18A 6gneA-2xsjA:
undetectable		 6gneA-2xsjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 LYS A  25
LEU A  51
ALA A  28
LEU A  50
 None
 1.45A 6gnrA-2xsjA:
undetectable		 6gnrA-2xsjA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		4 / 4 LYS A  25
LEU A  51
ALA A  28
LEU A  50
 None
 1.46A 6gnrB-2xsjA:
undetectable		 6gnrB-2xsjA:
14.71