SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 THR A 344
ASP A 375
SER A 377
 None
 0.69A 2nxeA-2xssA:
undetectable		 2nxeA-2xssA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 THR A 344
ASP A 375
SER A 377
 None
 0.71A 2nxeB-2xssA:
undetectable		 2nxeB-2xssA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 GLN A 490
LEU A 492
GLU A 489
LEU A 452
 None
 0.75A 3h5gA-2xssA:
undetectable
3h5gC-2xssA:
undetectable		 3h5gA-2xssA:
11.05
3h5gC-2xssA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ARG A 432
PHE A 433
PRO A 434
 None
 0.53A 3zoaB-2xssA:
undetectable		 3zoaB-2xssA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 GLU A 390
GLU A 392
TYR A 409
VAL A 415
 None
 1.06A 4a97A-2xssA:
undetectable		 4a97A-2xssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 GLU A 390
GLU A 392
TYR A 409
VAL A 415
 None
 1.04A 4a97D-2xssA:
undetectable		 4a97D-2xssA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 GLU A 390
GLU A 392
TYR A 409
VAL A 415
 None
 1.11A 4a97H-2xssA:
undetectable		 4a97H-2xssA:
21.94