SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 7 LEU A  71
PHE A  99
VAL A 101
VAL A 109
 None
 0.64A 1epbA-2xstA:
18.1		 1epbA-2xstA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 ASP A  87
HIS A  74
HIS A  72
 None
 0.61A 1oe1A-2xstA:
undetectable		 1oe1A-2xstA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 ASP A  87
HIS A  74
HIS A  72
 None
 0.60A 1oe3A-2xstA:
undetectable		 1oe3A-2xstA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 ASP A  87
HIS A  74
HIS A  72
 None
 0.62A 2xxgA-2xstA:
undetectable		 2xxgA-2xstA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 ASP A  87
HIS A  74
HIS A  72
 None
 0.65A 2xxgC-2xstA:
undetectable		 2xxgC-2xstA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 7 GLY A 105
ASP A 108
TYR A 106
ARG A 110
 None
 1.21A 3arrA-2xstA:
undetectable		 3arrA-2xstA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 7 GLY A 105
ASP A 108
TYR A 106
ARG A 110
 None
 1.24A 3aruA-2xstA:
undetectable		 3aruA-2xstA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2xst LIPOCALIN 15
(Homo
sapiens) 		5 / 9 TYR A 139
LEU A 104
VAL A  39
PHE A  77
VAL A  86
 None
None
EDO  A1174 ( 4.7A)
EDO  A1174 (-4.6A)
None
 1.45A 3jwqA-2xstA:
undetectable		 3jwqA-2xstA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 PHE A 119
SER A 146
GLN A 148
 None
 0.33A 3smtA-2xstA:
undetectable		 3smtA-2xstA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 8 ASP A 113
SER A 146
PHE A 119
ASP A 155
 None
 1.14A 4kttA-2xstA:
undetectable		 4kttA-2xstA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 8 ASP A 113
SER A 146
PHE A 119
ASP A 155
 None
 1.09A 4kttC-2xstA:
undetectable		 4kttC-2xstA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2xst LIPOCALIN 15
(Homo
sapiens) 		4 / 8 ASP A 113
SER A 146
PHE A 119
ASP A 155
 None
 1.08A 4ndnA-2xstA:
undetectable		 4ndnA-2xstA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2xst LIPOCALIN 15
(Homo
sapiens) 		5 / 12 ASP A 115
PHE A  33
PHE A  99
LEU A 122
TYR A 139
 None
 1.39A 5ef8B-2xstA:
undetectable		 5ef8B-2xstA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 TYR A 106
TYR A 139
GLN A 137
 None
 0.87A 5jsdA-2xstA:
undetectable
5jsdB-2xstA:
undetectable		 5jsdA-2xstA:
13.00
5jsdB-2xstA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 TYR A 106
TYR A 139
GLN A 137
 None
 0.88A 5jsdB-2xstA:
undetectable
5jsdC-2xstA:
undetectable		 5jsdB-2xstA:
13.00
5jsdC-2xstA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2xst LIPOCALIN 15
(Homo
sapiens) 		3 / 3 ALA A  20
VAL A 136
TYR A 123
 None
 0.70A 5zmqH-2xstA:
undetectable		 5zmqH-2xstA:
21.86