SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 PHE A 420
GLY A 408
LEU A 446
PHE A 475
 None
 0.82A 1gsfC-2xswA:
undetectable		 1gsfC-2xswA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 11 LEU A 510
ILE A 421
VAL A 465
THR A 466
PHE A 523
 None
 1.20A 1tw4A-2xswA:
undetectable		 1tw4A-2xswA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 10 LEU A 510
ILE A 421
VAL A 465
THR A 466
PHE A 523
 None
 1.19A 1tw4B-2xswA:
0.3		 1tw4B-2xswA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 9 PHE A 413
PHE A 420
VAL A 335
PHE A 411
LEU A 301
 None
 1.09A 1wrkA-2xswA:
undetectable
1wrkB-2xswA:
undetectable		 1wrkA-2xswA:
16.67
1wrkB-2xswA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A 301
PHE A 413
PHE A 420
PHE A 411
 None
 0.95A 1wrlE-2xswA:
undetectable
1wrlF-2xswA:
undetectable		 1wrlE-2xswA:
16.67
1wrlF-2xswA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 PHE A 473
PHE A 420
PHE A 411
VAL A 593
 None
 1.08A 2lh6A-2xswA:
undetectable		 2lh6A-2xswA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A 421
SER A 423
ARG A 435
ILE A 519
 None
 0.80A 2q6hA-2xswA:
undetectable		 2q6hA-2xswA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.21A 2y69C-2xswA:
undetectable
2y69J-2xswA:
undetectable		 2y69C-2xswA:
21.62
2y69J-2xswA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.17A 3ablC-2xswA:
undetectable
3ablJ-2xswA:
undetectable		 3ablC-2xswA:
21.62
3ablJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.21A 3abmC-2xswA:
undetectable
3abmJ-2xswA:
undetectable		 3abmC-2xswA:
21.62
3abmJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 4 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.16A 3ag1P-2xswA:
0.0
3ag1W-2xswA:
0.0		 3ag1P-2xswA:
21.62
3ag1W-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.18A 3ag3C-2xswA:
undetectable
3ag3J-2xswA:
undetectable		 3ag3C-2xswA:
21.62
3ag3J-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 4 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.16A 3ag3P-2xswA:
0.0
3ag3W-2xswA:
0.0		 3ag3P-2xswA:
21.62
3ag3W-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 3 CYH A 385
PHE A 384
PHE A 413
 None
 0.95A 3cr5X-2xswA:
undetectable		 3cr5X-2xswA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A 382
VAL A 361
ARG A 379
TYR A 614
 None
 1.06A 3p6hA-2xswA:
undetectable		 3p6hA-2xswA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 4 SER A 582
GLY A 476
GLU A 525
 None
 0.64A 3raeA-2xswA:
undetectable
3raeC-2xswA:
undetectable		 3raeA-2xswA:
22.82
3raeC-2xswA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 8 PHE A 413
PHE A 418
PHE A 294
ALA A 300
 None
 0.95A 3t3sF-2xswA:
undetectable		 3t3sF-2xswA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 421
LEU A 559
LEU A 510
ILE A 519
THR A 395
 None
 1.03A 4m2xC-2xswA:
undetectable		 4m2xC-2xswA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 GLY A 337
LEU A 333
ILE A 409
LEU A 362
 None
 0.88A 4o8fA-2xswA:
undetectable		 4o8fA-2xswA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 6 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.16A 5b1bC-2xswA:
undetectable
5b1bJ-2xswA:
undetectable		 5b1bC-2xswA:
21.62
5b1bJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 3 GLN A 549
THR A 546
ASP A 544
 None
 0.86A 5k9dA-2xswA:
undetectable		 5k9dA-2xswA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 6 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.11A 5w97C-2xswA:
undetectable
5w97J-2xswA:
undetectable		 5w97C-2xswA:
21.62
5w97J-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.17A 5wauC-2xswA:
undetectable
5wauJ-2xswA:
undetectable		 5wauC-2xswA:
21.62
5wauJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.18A 5xdqC-2xswA:
undetectable
5xdqJ-2xswA:
undetectable		 5xdqC-2xswA:
21.62
5xdqJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.18A 5xdqP-2xswA:
undetectable
5xdqW-2xswA:
undetectable		 5xdqP-2xswA:
21.62
5xdqW-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.17A 5xdxC-2xswA:
undetectable
5xdxJ-2xswA:
undetectable		 5xdxC-2xswA:
22.16
5xdxJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 5 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.17A 5xdxP-2xswA:
undetectable
5xdxW-2xswA:
undetectable		 5xdxP-2xswA:
22.16
5xdxW-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 THR A 392
LEU A 407
ILE A 421
THR A 422
 None
 1.03A 5zsfA-2xswA:
undetectable
5zsfB-2xswA:
undetectable		 5zsfA-2xswA:
11.05
5zsfB-2xswA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		4 / 7 GLU A 320
THR A 581
PRO A 315
PRO A 586
 None
 1.45A 6a4iB-2xswA:
undetectable		 6a4iB-2xswA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		5 / 11 TYR A 439
THR A 466
SER A 423
ALA A 406
LEU A 437
 None
 1.35A 6efnA-2xswA:
undetectable		 6efnA-2xswA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 557
PHE A 523
PHE A 480
 None
 1.05A 6nknC-2xswA:
undetectable
6nknJ-2xswA:
undetectable		 6nknC-2xswA:
21.62
6nknJ-2xswA:
10.08