SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 8 GLU A 210
GLY A 396
SER A 370
ASP A 318
ASP A 245
 PO4  A 501 (-4.0A)
None
None
MG  A 500 (-3.2A)
MG  A 500 (-2.6A)
 1.50A 1m4iA-2xsxA:
undetectable		 1m4iA-2xsxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 11 LEU A 259
PHE A 251
VAL A 289
LEU A 224
LEU A 276
 EDO  A 504 ( 4.7A)
None
None
None
None
 1.13A 1mx1B-2xsxA:
undetectable		 1mx1B-2xsxA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 4 SER A 115
VAL A  22
PHE A 380
VAL A 344
 None
 1.34A 1o86A-2xsxA:
undetectable		 1o86A-2xsxA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 TYR A 407
ILE A 170
PRO A 172
ALA A 181
 None
 1.02A 1oniD-2xsxA:
undetectable
1oniE-2xsxA:
undetectable		 1oniD-2xsxA:
16.59
1oniE-2xsxA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 11 MET A   3
LEU A  77
VAL A  22
ALA A 117
LEU A 116
 None
 0.94A 2c12F-2xsxA:
undetectable		 2c12F-2xsxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		3 / 3 ILE A 184
ILE A 231
LEU A 404
 EDO  A 506 (-4.9A)
None
None
 0.53A 2prgA-2xsxA:
undetectable		 2prgA-2xsxA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 8 LEU A 388
THR A 395
VAL A 367
GLY A 391
 None
 0.67A 3dcjB-2xsxA:
undetectable		 3dcjB-2xsxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
 None
 1.24A 4j24C-2xsxA:
undetectable		 4j24C-2xsxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
 None
 1.18A 4j26B-2xsxA:
undetectable		 4j26B-2xsxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		3 / 3 PRO A  75
LEU A  78
HIS A  25
 None
 0.71A 4pevA-2xsxA:
undetectable		 4pevA-2xsxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 12 ALA A  33
ASP A 378
LEU A  24
HIS A 133
LEU A 130
 None
EDO  A 511 (-4.3A)
None
None
None
 1.08A 4xi3A-2xsxA:
undetectable		 4xi3A-2xsxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 10 GLY A 155
ASN A 151
ILE A 217
LEU A 163
TYR A 200
 None
 1.06A 4xj7A-2xsxA:
undetectable
4xj7B-2xsxA:
undetectable		 4xj7A-2xsxA:
23.12
4xj7B-2xsxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 6 ALA A 123
LYS A 126
LEU A 130
LEU A 137
 None
 1.22A 4xp3A-2xsxA:
undetectable		 4xp3A-2xsxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.69A 5a06A-2xsxA:
undetectable		 5a06A-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.68A 5a06B-2xsxA:
undetectable		 5a06B-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.67A 5a06C-2xsxA:
undetectable		 5a06C-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.66A 5a06E-2xsxA:
undetectable		 5a06E-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		4 / 7 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.68A 5a06F-2xsxA:
undetectable		 5a06F-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		5 / 12 GLY A 174
PHE A 150
THR A 390
GLU A 414
GLY A 425
 None
 1.01A 5veuH-2xsxA:
undetectable		 5veuH-2xsxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xsx BETA-ENOLASE
(Homo
sapiens) 		3 / 3 LYS A 120
LEU A 112
ASP A 378
 None
None
EDO  A 511 (-4.3A)
 0.86A 5zv2A-2xsxA:
undetectable		 5zv2A-2xsxA:
11.50