SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 7 SER A 298
GLY A 306
HIS A 304
ILE A 286
 None
 0.96A 1gtnF-2xszA:
undetectable
1gtnG-2xszA:
undetectable		 1gtnF-2xszA:
12.53
1gtnG-2xszA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 7 GLU A 342
GLU A 339
GLU A 343
GLU A 346
 None
 1.08A 1knyA-2xszA:
undetectable
1knyB-2xszA:
undetectable		 1knyA-2xszA:
21.49
1knyB-2xszA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 7 SER A 335
ASP A 334
GLU A 337
GLU A 300
 None
 0.91A 1knyA-2xszA:
undetectable
1knyB-2xszA:
undetectable		 1knyA-2xszA:
21.49
1knyB-2xszA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 8 GLU A 300
SER A 335
ASP A 334
GLU A 337
 None
 0.97A 1knyA-2xszA:
undetectable
1knyB-2xszA:
undetectable		 1knyA-2xszA:
21.49
1knyB-2xszA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 GLY A  89
GLY A  84
GLN A  56
THR A 274
ILE A 285
 ATP  A 501 (-3.2A)
None
None
None
ATP  A 501 (-3.7A)
 1.36A 2azxB-2xszA:
undetectable		 2azxB-2xszA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 8 VAL A 269
LEU A 263
PRO A 258
HIS A 259
 None
 0.91A 2ddwA-2xszA:
undetectable		 2ddwA-2xszA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 11 GLY A  89
GLY A  84
GLN A  56
THR A 274
ILE A 285
 ATP  A 501 (-3.2A)
None
None
None
ATP  A 501 (-3.7A)
 1.35A 2dr2A-2xszA:
undetectable		 2dr2A-2xszA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 4 SER A 103
GLY A 102
HIS A  32
ASP A 213
 None
None
ATP  A 501 (-3.7A)
ATP  A 501 ( 4.6A)
 1.39A 2oxtC-2xszA:
undetectable		 2oxtC-2xszA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 5 ILE A 271
HIS A 259
ARG A 273
GLY A  84
 None
 1.29A 3b9mA-2xszA:
undetectable		 3b9mA-2xszA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 LEU A 136
SER A 232
LEU A 151
THR A 150
PRO A 236
 None
 1.22A 3iz0B-2xszA:
undetectable		 3iz0B-2xszA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 ILE A 239
GLY A  55
LEU A  38
ILE A 288
ILE A 285
 None
None
None
None
ATP  A 501 (-3.7A)
 1.09A 3pwwA-2xszA:
undetectable		 3pwwA-2xszA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 5 TYR A 225
THR A 224
PHE A 223
LEU A 230
 None
 1.02A 3qelC-2xszA:
2.8		 3qelC-2xszA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		3 / 3 GLY A  87
GLY A  89
THR A  91
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
 0.44A 3si7B-2xszA:
undetectable		 3si7B-2xszA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 7 ILE A 239
ILE A 272
GLU A  68
LEU A  38
 None
 0.65A 3ua5B-2xszA:
undetectable		 3ua5B-2xszA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  89
GLN A  56
VAL A  54
VAL A 318
 None
ATP  A 501 (-3.2A)
None
ATP  A 501 (-4.2A)
None
 1.32A 4okwA-2xszA:
undetectable		 4okwA-2xszA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  89
GLN A  56
VAL A  54
VAL A 318
 None
ATP  A 501 (-3.2A)
None
ATP  A 501 (-4.2A)
None
 1.33A 4okxA-2xszA:
undetectable		 4okxA-2xszA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 5 LEU A  38
ALA A  98
VAL A  80
ILE A 237
 None
 0.95A 4xe3B-2xszA:
undetectable		 4xe3B-2xszA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		3 / 3 LEU A 210
PHE A 107
ILE A 239
 None
 0.77A 5dzk1-2xszA:
undetectable
5dzkF-2xszA:
2.2
5dzkM-2xszA:
undetectable		 5dzk1-2xszA:
20.00
5dzkF-2xszA:
20.00
5dzkM-2xszA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 SER A 317
GLN A 291
THR A 312
GLY A 306
GLN A 284
 None
 1.21A 5oj0A-2xszA:
undetectable		 5oj0A-2xszA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		4 / 8 VAL A 209
GLN A  99
GLY A  37
LEU A  38
 None
 0.85A 5w3jB-2xszA:
undetectable		 5w3jB-2xszA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 HIS A 259
GLY A 245
ILE A 272
GLY A  84
SER A 242
 None
 1.14A 6c2mA-2xszA:
undetectable		 6c2mA-2xszA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2xsz RUVB-LIKE 1
(Homo
sapiens) 		5 / 9 VAL A 209
LEU A  38
LEU A  93
VAL A  67
CYH A  63
 None
 1.31A 6czmD-2xszA:
undetectable
6czmE-2xszA:
undetectable		 6czmD-2xszA:
22.78
6czmE-2xszA:
22.78