SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 ILE A 127
MET A 257
LEU A 150
LEU A 143
ILE A 264
 None
 1.13A 1bsxA-2xt0A:
undetectable		 1bsxA-2xt0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 ILE A 127
MET A 257
LEU A 150
LEU A 143
ILE A 264
 None
 1.13A 1bsxB-2xt0A:
undetectable		 1bsxB-2xt0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 11 ILE A 213
ARG A 103
GLY A 222
LEU A 128
SER A 104
 None
None
SO4  A1298 (-3.0A)
None
None
 1.36A 2bxeA-2xt0A:
undetectable		 2bxeA-2xt0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2001_1
(SERUM ALBUMIN)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 9 ILE A 213
ARG A 103
GLY A 222
LEU A 128
SER A 104
 None
None
SO4  A1298 (-3.0A)
None
None
 1.43A 2bxgB-2xt0A:
0.1		 2bxgB-2xt0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 7 ARG A 103
GLY A  99
SER A 104
PHE A 100
 None
 1.09A 2c8aD-2xt0A:
undetectable		 2c8aD-2xt0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.48A 2nnkB-2xt0A:
undetectable		 2nnkB-2xt0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.49A 2q63A-2xt0A:
undetectable		 2q63A-2xt0A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		3 / 3 ARG A 209
GLY A 206
SER A 104
 None
 0.62A 2xctB-2xt0A:
1.9		 2xctB-2xt0A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.45A 3k4vB-2xt0A:
undetectable		 3k4vB-2xt0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.46A 3ndtA-2xt0A:
undetectable		 3ndtA-2xt0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.45A 3ndtB-2xt0A:
undetectable		 3ndtB-2xt0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.42A 3ndtC-2xt0A:
undetectable		 3ndtC-2xt0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.43A 3nduC-2xt0A:
undetectable		 3nduC-2xt0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.49A 3tkgB-2xt0A:
undetectable		 3tkgB-2xt0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		6 / 12 LEU A 252
ASP A 123
GLY A  54
ILE A 183
PRO A 250
VAL A 251
 None
 1.48A 3tl9A-2xt0A:
undetectable		 3tl9A-2xt0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 PHE A 100
GLY A  99
ALA A 205
GLY A 206
MET A   1
 None
 1.29A 3v3oB-2xt0A:
2.1		 3v3oB-2xt0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 LEU A 114
LEU A 109
LEU A 106
ALA A 107
MET A  35
 None
 1.23A 4fn9B-2xt0A:
undetectable		 4fn9B-2xt0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 5 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.38A 4lvcA-2xt0A:
5.5		 4lvcA-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 5 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.37A 4lvcC-2xt0A:
undetectable		 4lvcC-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 5 GLY A  54
ASP A 123
GLU A 282
VAL A 273
 None
 1.00A 4nkvD-2xt0A:
undetectable		 4nkvD-2xt0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 GLY A 157
GLY A 159
SER A 155
LEU A 154
ALA A 151
 None
 1.06A 4uckB-2xt0A:
undetectable		 4uckB-2xt0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		3 / 3 THR A 187
ASP A 188
ALA A 189
 None
 0.00A 5g5gB-2xt0A:
undetectable		 5g5gB-2xt0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 MET A  65
TYR A  62
GLN A 122
GLY A 246
VAL A 120
 None
 1.47A 5g6sB-2xt0A:
undetectable
5g6sC-2xt0A:
undetectable		 5g6sB-2xt0A:
21.82
5g6sC-2xt0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 4 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.35A 5m5kA-2xt0A:
undetectable		 5m5kA-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 4 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.34A 5m5kC-2xt0A:
2.5		 5m5kC-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 4 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.33A 5m66B-2xt0A:
4.5		 5m66B-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 PHE A 210
PHE A 100
GLY A  54
LEU A 105
PHE A  30
 None
 1.05A 5v5zA-2xt0A:
undetectable		 5v5zA-2xt0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		3 / 3 GLY A 246
THR A 187
PRO A 184
 None
 0.65A 5v5zA-2xt0A:
undetectable		 5v5zA-2xt0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 10 ARG A  63
PRO A  18
GLY A 185
ILE A 186
ALA A 189
 None
 1.16A 5vyhA-2xt0A:
undetectable		 5vyhA-2xt0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 MET A  65
VAL A 280
GLY A 126
GLY A 125
MET A 257
 None
 0.98A 6brdB-2xt0A:
undetectable		 6brdB-2xt0A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		3 / 3 TYR A  96
HIS A 101
PHE A  84
 None
 1.06A 6esmA-2xt0A:
undetectable		 6esmA-2xt0A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 10 GLY A 239
VAL A 140
ASP A 141
THR A 241
ILE A 264
 None
 1.08A 6exiA-2xt0A:
5.5		 6exiA-2xt0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 10 GLY A 239
VAL A 140
ASP A 141
THR A 241
ILE A 264
 None
 1.05A 6exiB-2xt0A:
2.3		 6exiB-2xt0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 GLY A 239
VAL A 140
ASP A 141
THR A 241
ILE A 264
 None
 1.08A 6exiC-2xt0A:
2.3
6exiD-2xt0A:
2.8		 6exiC-2xt0A:
20.93
6exiD-2xt0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		5 / 12 GLY A 239
VAL A 140
ASP A 141
THR A 241
ILE A 264
 None
 1.07A 6exiC-2xt0A:
2.4
6exiD-2xt0A:
2.8		 6exiC-2xt0A:
20.93
6exiD-2xt0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 4 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.34A 6f3mB-2xt0A:
6.5		 6f3mB-2xt0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 5 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.38A 6gbnA-2xt0A:
undetectable		 6gbnA-2xt0A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		4 / 5 GLN A 236
THR A 235
THR A 241
LEU A 130
 None
 1.39A 6gbnD-2xt0A:
undetectable		 6gbnD-2xt0A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt0 HALOALKANE
DEHALOGENASE
(Plesiocystis
pacifica) 		3 / 3 ARG A  10
PHE A  17
PHE A 198
 SO4  A1300 (-2.7A)
None
None
 1.00A 6nknC-2xt0A:
undetectable
6nknJ-2xt0A:
undetectable		 6nknC-2xt0A:
21.23
6nknJ-2xt0A:
17.71