SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A1061
ASP A1004
VAL A 971
HIS A1055
 None
CA  A2003 (-2.5A)
None
CA  A2003 (-3.8A)
 1.31A 1ekjG-2xt6A:
undetectable
1ekjH-2xt6A:
undetectable		 1ekjG-2xt6A:
12.84
1ekjH-2xt6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A1094
LEU A1051
LEU A1184
LEU A1195
 None
 0.91A 1errA-2xt6A:
undetectable		 1errA-2xt6A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 723
ARG A 728
PHE A 731
TRP A 462
 None
 0.80A 1fapB-2xt6A:
undetectable		 1fapB-2xt6A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A1006
LEU A1008
LEU A 927
LEU A 883
MET A 970
 None
 1.23A 1mx1B-2xt6A:
undetectable		 1mx1B-2xt6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 900
SER A 899
ARG A 897
ARG A 618
SER A 951
 None
 1.21A 1tufA-2xt6A:
undetectable
1tufB-2xt6A:
undetectable		 1tufA-2xt6A:
17.85
1tufB-2xt6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.92A 1v54P-2xt6A:
undetectable
1v54W-2xt6A:
undetectable		 1v54P-2xt6A:
12.79
1v54W-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLU A 892
GLY A 940
MET A 839
LEU A 930
ALA A 931
 None
 1.01A 1x7pA-2xt6A:
2.4
1x7pB-2xt6A:
2.5		 1x7pA-2xt6A:
14.12
1x7pB-2xt6A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A 413
LEU A 410
LYS A 366
 None
 1.23A 1yajK-2xt6A:
2.1		 1yajK-2xt6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR A 600
THR A 671
LEU A 616
VAL A 617
GLY A 615
 None
 1.32A 2cp4A-2xt6A:
undetectable		 2cp4A-2xt6A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.92A 2dyrP-2xt6A:
undetectable
2dyrW-2xt6A:
undetectable		 2dyrP-2xt6A:
12.79
2dyrW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.91A 2eikC-2xt6A:
undetectable
2eikJ-2xt6A:
undetectable		 2eikC-2xt6A:
12.79
2eikJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.87A 2eikP-2xt6A:
undetectable
2eikW-2xt6A:
undetectable		 2eikP-2xt6A:
12.79
2eikW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.91A 2eilP-2xt6A:
undetectable
2eilW-2xt6A:
undetectable		 2eilP-2xt6A:
12.79
2eilW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 927
LEU A 886
LEU A 972
ARG A 867
ILE A 843
 None
 1.33A 2qd3A-2xt6A:
5.0		 2qd3A-2xt6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ARG A 897
TYR A 666
SER A 899
GLY A 900
THR A 903
 None
 1.32A 2xffA-2xt6A:
undetectable		 2xffA-2xt6A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 738
THR A 696
ARG A 690
ILE A 387
PRO A 389
 None
 1.22A 2yzqA-2xt6A:
undetectable		 2yzqA-2xt6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.88A 3ag2C-2xt6A:
undetectable		 3ag2C-2xt6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.86A 3ag2P-2xt6A:
undetectable
3ag2W-2xt6A:
undetectable		 3ag2P-2xt6A:
12.79
3ag2W-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.94A 3ag4C-2xt6A:
undetectable
3ag4J-2xt6A:
undetectable		 3ag4C-2xt6A:
12.79
3ag4J-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.96A 3ag4P-2xt6A:
undetectable
3ag4W-2xt6A:
undetectable		 3ag4P-2xt6A:
12.79
3ag4W-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.93A 3asnC-2xt6A:
undetectable
3asnJ-2xt6A:
undetectable		 3asnC-2xt6A:
12.79
3asnJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.97A 3asoC-2xt6A:
undetectable
3asoJ-2xt6A:
undetectable		 3asoC-2xt6A:
12.79
3asoJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.13A 3eeyA-2xt6A:
undetectable		 3eeyA-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.14A 3eeyE-2xt6A:
undetectable		 3eeyE-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyF-2xt6A:
undetectable		 3eeyF-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyH-2xt6A:
undetectable		 3eeyH-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 671
GLY A 669
ILE A 702
HIS A 673
THR A 657
 None
 1.12A 3eeyJ-2xt6A:
2.2		 3eeyJ-2xt6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.40A 3elzA-2xt6A:
undetectable		 3elzA-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.43A 3elzB-2xt6A:
undetectable		 3elzB-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 725
VAL A 545
LEU A 599
ILE A 549
TYR A 586
 None
 1.38A 3elzC-2xt6A:
undetectable		 3elzC-2xt6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A 899
GLY A 961
VAL A 612
GLY A 957
VAL A 971
 None
 1.35A 3f8wB-2xt6A:
undetectable		 3f8wB-2xt6A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLN A 524
ASP A 519
ILE A 549
VAL A 597
VAL A 533
 None
 1.19A 3fi0K-2xt6A:
undetectable		 3fi0K-2xt6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLN A 524
ASP A 519
ILE A 549
VAL A 597
VAL A 533
 None
 1.21A 3fi0O-2xt6A:
undetectable		 3fi0O-2xt6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.21A 3jq7B-2xt6A:
2.9		 3jq7B-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.19A 3jqaA-2xt6A:
2.7		 3jqaA-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.19A 3jqaB-2xt6A:
undetectable		 3jqaB-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.22A 3jqaC-2xt6A:
3.0		 3jqaC-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 802
SER A 484
ASP A 519
TYR A 481
 None
 1.22A 3jqaD-2xt6A:
2.9		 3jqaD-2xt6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 159
PHE A 339
PHE A 338
 None
 0.72A 3lk0D-2xt6A:
0.4		 3lk0D-2xt6A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 643
HIS A 673
MET A 641
 None
 0.70A 3mihA-2xt6A:
undetectable		 3mihA-2xt6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 197
GLN A 274
LEU A 255
LEU A 196
ILE A 165
 None
 1.30A 3nbqA-2xt6A:
6.3		 3nbqA-2xt6A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 197
GLN A 274
LEU A 255
LEU A 196
ILE A 165
 None
 1.34A 3nbqD-2xt6A:
3.5		 3nbqD-2xt6A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 MET A 517
VAL A 709
PHE A 707
VAL A 447
ILE A 737
 None
 1.21A 3rf4A-2xt6A:
undetectable
3rf4C-2xt6A:
undetectable		 3rf4A-2xt6A:
7.92
3rf4C-2xt6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 737
MET A 517
VAL A 709
PHE A 707
VAL A 447
 None
 1.18A 3rf4A-2xt6A:
undetectable
3rf4B-2xt6A:
undetectable		 3rf4A-2xt6A:
7.92
3rf4B-2xt6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 737
MET A 517
VAL A 709
PHE A 707
VAL A 447
 None
 1.21A 3rf4B-2xt6A:
undetectable
3rf4C-2xt6A:
undetectable		 3rf4B-2xt6A:
7.92
3rf4C-2xt6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 847
GLY A 844
GLY A 887
PHE A 943
ALA A 913
 None
 1.21A 3sueD-2xt6A:
undetectable		 3sueD-2xt6A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.96A 3x2qC-2xt6A:
undetectable
3x2qJ-2xt6A:
undetectable		 3x2qC-2xt6A:
12.79
3x2qJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.99A 3x2qP-2xt6A:
undetectable
3x2qW-2xt6A:
undetectable		 3x2qP-2xt6A:
12.79
3x2qW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 341
PHE A 339
TYR A 163
PHE A 224
 None
 1.11A 4a97E-2xt6A:
undetectable		 4a97E-2xt6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 324
ILE A 317
THR A 328
PHE A 325
 None
 1.06A 4acbC-2xt6A:
4.1		 4acbC-2xt6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A1038
ILE A1039
THR A1183
PHE A1180
 None
 1.04A 4acbC-2xt6A:
4.1		 4acbC-2xt6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1123
ALA A1225
LEU A1222
THR A1224
 None
 0.95A 4d7bA-2xt6A:
undetectable		 4d7bA-2xt6A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS A 620
LEU A 616
ALA A 619
 None
 0.72A 4ikiA-2xt6A:
undetectable		 4ikiA-2xt6A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 439
TYR A 377
LEU A 410
LEU A 432
 None
 1.00A 4l1xA-2xt6A:
undetectable		 4l1xA-2xt6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A1150
LEU A1094
GLU A1095
 None
 0.68A 4l3gF-2xt6A:
undetectable		 4l3gF-2xt6A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LYS A1118
ARG A1200
GLN A1218
GLU A1122
 None
 1.20A 4mv7A-2xt6A:
2.6		 4mv7A-2xt6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 995
ILE A 987
ILE A 988
ARG A1062
LEU A1007
 None
 1.08A 4mwzA-2xt6A:
undetectable		 4mwzA-2xt6A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ARG A 867
ALA A 879
ALA A 913
VAL A 914
GLN A 910
 None
 1.42A 4ryaA-2xt6A:
undetectable		 4ryaA-2xt6A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 321
ASP A 313
ALA A 276
TYR A 312
 None
 1.19A 4zz8A-2xt6A:
undetectable		 4zz8A-2xt6A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 911
TYR A1048
GLU A 882
 None
 0.69A 4zzbE-2xt6A:
undetectable		 4zzbE-2xt6A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
PHE A1192
 None
 1.15A 5b1aC-2xt6A:
undetectable
5b1aJ-2xt6A:
undetectable		 5b1aC-2xt6A:
12.79
5b1aJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.97A 5b1aP-2xt6A:
undetectable
5b1aW-2xt6A:
undetectable		 5b1aP-2xt6A:
12.79
5b1aW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.93A 5b1bP-2xt6A:
undetectable
5b1bW-2xt6A:
undetectable		 5b1bP-2xt6A:
12.79
5b1bW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.96A 5b3sC-2xt6A:
undetectable
5b3sJ-2xt6A:
undetectable		 5b3sC-2xt6A:
12.79
5b3sJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.99A 5b3sP-2xt6A:
undetectable		 5b3sP-2xt6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 871
GLY A 844
LEU A 883
ARG A 868
LEU A 864
 None
 1.00A 5c0oG-2xt6A:
undetectable		 5c0oG-2xt6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA612_0
(SERUM ALBUMIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A1022
HIS A1013
GLU A1170
PRO A1171
 None
 1.29A 5dbyA-2xt6A:
1.1		 5dbyA-2xt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 414
VAL A 405
LEU A 436
 None
 0.55A 5e5jB-2xt6A:
undetectable		 5e5jB-2xt6A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 233
ALA A 230
GLN A 274
GLY A 197
SER A 254
 None
 0.81A 5hfjF-2xt6A:
undetectable		 5hfjF-2xt6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
PHE A1192
 None
 1.15A 5iy5C-2xt6A:
undetectable
5iy5J-2xt6A:
undetectable		 5iy5C-2xt6A:
12.96
5iy5J-2xt6A:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLU A 509
GLN A 497
LEU A 496
THR A 498
 None
 1.00A 5syjB-2xt6A:
2.1		 5syjB-2xt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 972
GLY A 893
ALA A 913
THR A 925
GLY A 941
 None
 1.00A 5veuH-2xt6A:
undetectable		 5veuH-2xt6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 488
ARG A 744
TYR A 742
ASP A 712
THR A 513
 None
 1.28A 5vlmD-2xt6A:
0.4		 5vlmD-2xt6A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 530
VAL A 725
ASP A 726
 None
 0.61A 5x23A-2xt6A:
undetectable		 5x23A-2xt6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 963
ARG A 897
GLU A 959
TYR A 962
 None
 1.47A 5x7pA-2xt6A:
undetectable		 5x7pA-2xt6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 963
ARG A 897
GLU A 959
TYR A 962
 None
 1.44A 5x7pB-2xt6A:
undetectable		 5x7pB-2xt6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 963
ARG A 897
GLU A 959
TYR A 962
 None
 1.46A 5x7qA-2xt6A:
undetectable		 5x7qA-2xt6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 963
ARG A 897
GLU A 959
TYR A 962
 None
 1.48A 5x7qB-2xt6A:
1.1		 5x7qB-2xt6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A 985
HIS A1011
ASN A 982
LEU A1029
 None
 1.27A 5xdhA-2xt6A:
undetectable
5xdhC-2xt6A:
undetectable		 5xdhA-2xt6A:
6.01
5xdhC-2xt6A:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLN A 799
ARG A 802
TYR A 554
ASP A 523
 None
 1.23A 5yf0A-2xt6A:
3.7		 5yf0A-2xt6A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.97A 5zcqC-2xt6A:
undetectable
5zcqJ-2xt6A:
undetectable		 5zcqC-2xt6A:
12.79
5zcqJ-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS A 894
LEU A 972
ASP A1004
 None
None
CA  A2003 (-2.5A)
 0.87A 5zv2A-2xt6A:
undetectable		 5zv2A-2xt6A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 911
HIS A 912
ARG A 867
 None
 0.79A 6dwdD-2xt6A:
undetectable		 6dwdD-2xt6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 597
GLU A 532
ILE A 522
 None
 0.50A 6f7lB-2xt6A:
undetectable		 6f7lB-2xt6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 746
HIS A 747
ARG A 745
GLU A 749
GLY A 750
 None
TPP  A2001 (-4.5A)
None
None
None
 1.35A 6gngA-2xt6A:
undetectable		 6gngA-2xt6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 MET A 641
LEU A 640
THR A 668
LEU A 530
 None
 1.16A 6mvxA-2xt6A:
undetectable
6mvxB-2xt6A:
2.7
6mvxC-2xt6A:
2.8		 6mvxA-2xt6A:
14.12
6mvxB-2xt6A:
14.12
6mvxC-2xt6A:
14.12