SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 4 ALA D  40
ARG D  38
GLN D  43
GLU D  46
 None
 0.98A 1lqtB-2xtjD:
undetectable		 1lqtB-2xtjD:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 4 ALA D  40
ARG D  38
GLN D  43
GLU D  46
 None
 1.02A 1lquB-2xtjD:
undetectable		 1lquB-2xtjD:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 8 LEU E 142
ALA E 155
SER E 145
SER E 146
 None
 0.95A 4ikkA-2xtjE:
undetectable
4ikkB-2xtjE:
undetectable		 4ikkA-2xtjE:
20.15
4ikkB-2xtjE:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		3 / 3 ARG C 141
GLN C 165
GLU C 164
 None
 0.87A 4tvtA-2xtjC:
undetectable		 4tvtA-2xtjC:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 6 ASP C 169
THR C 171
TYR C 139
THR C 108
 None
 1.41A 5b6iB-2xtjC:
undetectable		 5b6iB-2xtjC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		5 / 11 SER E 206
GLY E 152
THR E 153
ALA E 154
THR E 149
 None
 0.93A 5bxnH-2xtjE:
undetectable
5bxnI-2xtjE:
undetectable		 5bxnH-2xtjE:
21.88
5bxnI-2xtjE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 7 ALA D  92
THR D  91
VAL D 127
GLU D  89
 None
 0.74A 5ecmD-2xtjD:
undetectable		 5ecmD-2xtjD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		4 / 7 ALA D  92
THR D  91
VAL D 127
GLU D  89
 None
 0.81A 5ecoD-2xtjD:
undetectable		 5ecoD-2xtjD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		5 / 12 SER E 206
GLY E 152
THR E 153
ALA E 154
THR E 149
 None
 1.02A 6hwdH-2xtjE:
undetectable
6hwdI-2xtjE:
undetectable		 6hwdH-2xtjE:
18.11
6hwdI-2xtjE:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05
(Homo
sapiens) 		5 / 11 SER E 206
GLY E 152
THR E 153
ALA E 154
THR E 149
 None
 1.02A 6hwdV-2xtjE:
undetectable		 6hwdV-2xtjE:
18.11