SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 6 VAL A 535
GLY A 474
GLN A 591
TYR A 515
 None
 1.24A 1ekjC-2xtlA:
undetectable
1ekjD-2xtlA:
undetectable		 1ekjC-2xtlA:
19.08
1ekjD-2xtlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 LYS A 400
THR A 352
THR A 434
VAL A 432
 None
 0.84A 1ictD-2xtlA:
5.9		 1ictD-2xtlA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 197
SER A 238
TYR A 331
LEU A 284
LEU A 286
 None
 1.16A 1s19A-2xtlA:
undetectable		 1s19A-2xtlA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 PHE A 605
VAL A 479
LEU A 486
PHE A 461
LEU A 580
 None
 1.29A 1wrkA-2xtlA:
undetectable
1wrkB-2xtlA:
undetectable		 1wrkA-2xtlA:
11.53
1wrkB-2xtlA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 PRO A 195
VAL A 197
ALA A 297
ALA A 293
LEU A 286
 None
 1.17A 2x2nC-2xtlA:
undetectable		 2x2nC-2xtlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 TYR A 273
VAL A 261
THR A 271
 None
 0.85A 2ygnA-2xtlA:
2.9		 2ygnA-2xtlA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 VAL A 225
SER A 310
THR A 312
ASP A 279
ILE A 259
 None
 1.07A 3ddyA-2xtlA:
undetectable		 3ddyA-2xtlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 VAL A 414
VAL A 388
TYR A 412
VAL A 433
 None
 1.11A 3fhxB-2xtlA:
undetectable		 3fhxB-2xtlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 VAL A 565
VAL A 479
LEU A 587
SER A 586
 None
 0.86A 3hs6B-2xtlA:
undetectable		 3hs6B-2xtlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 4 ASP A 527
GLY A 525
LYS A 522
GLU A 524
 None
 1.48A 3hznD-2xtlA:
undetectable		 3hznD-2xtlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 PRO A 195
TYR A 331
THR A 232
ILE A 305
 None
 0.85A 3p4wC-2xtlA:
2.4		 3p4wC-2xtlA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 5 SER A 248
GLY A 281
VAL A 276
ASP A 278
 None
 0.98A 4eohA-2xtlA:
2.6		 4eohA-2xtlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 5 VAL A 479
LEU A 580
VAL A 607
PHE A 605
 None
 1.05A 4lb0B-2xtlA:
undetectable		 4lb0B-2xtlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 9 LEU A 253
ASP A 279
GLN A 280
THR A 376
ILE A 415
 None
 1.43A 4pcuA-2xtlA:
0.0
4pcuB-2xtlA:
0.0		 4pcuA-2xtlA:
22.80
4pcuB-2xtlA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 MET A 249
ALA A 311
THR A 232
VAL A 197
LEU A 284
 None
 1.28A 4qynA-2xtlA:
undetectable		 4qynA-2xtlA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 VAL A 462
THR A 464
ARG A 471
 None
 0.59A 5b2sB-2xtlA:
undetectable		 5b2sB-2xtlA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 VAL A 462
THR A 464
ARG A 471
 None
 0.58A 5b2tB-2xtlA:
undetectable		 5b2tB-2xtlA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 LYS A 480
ASP A 482
ILE A 577
 None
 0.90A 5kc4E-2xtlA:
3.0		 5kc4E-2xtlA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 PRO A 195
TYR A 331
THR A 232
ILE A 305
 None
 0.80A 5murB-2xtlA:
3.5		 5murB-2xtlA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 PRO A 195
TYR A 331
THR A 232
ILE A 305
 None
 0.87A 5mzrE-2xtlA:
2.3		 5mzrE-2xtlA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 VAL A 230
VAL A 197
LYS A 199
ASP A 247
 None
 0.77A 5y9mA-2xtlA:
undetectable		 5y9mA-2xtlA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 VAL A 230
VAL A 197
LYS A 199
ASP A 247
 None
 0.79A 5ywmX-2xtlA:
undetectable		 5ywmX-2xtlA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASP A 509
LEU A 508
ARG A 488
 None
 0.69A 7dfrA-2xtlA:
undetectable		 7dfrA-2xtlA:
17.21