SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 6 LEU A 144
VAL A  95
ILE A  26
ARG A 251
 None
 0.97A 1opjB-2xtpA:
undetectable		 1opjB-2xtpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 8 VAL A 129
THR A 141
GLY A 176
ALA A 174
 None
 0.81A 2a1hA-2xtpA:
undetectable
2a1hB-2xtpA:
undetectable		 2a1hA-2xtpA:
21.67
2a1hB-2xtpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 5 GLN A 121
THR A 119
THR A 146
HIS A 147
 None
 1.39A 2zj0C-2xtpA:
undetectable		 2zj0C-2xtpA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 8 ALA A 137
TYR A 219
HIS A 140
GLY A 134
 None
 0.88A 2zm9A-2xtpA:
undetectable		 2zm9A-2xtpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 5 GLN A 121
THR A 119
THR A 146
HIS A 147
 None
 1.43A 3glqA-2xtpA:
undetectable		 3glqA-2xtpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 5 GLN A 121
THR A 119
THR A 146
HIS A 147
 None
 1.44A 3glqB-2xtpA:
undetectable		 3glqB-2xtpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 5 GLN A 121
THR A 119
THR A 146
HIS A 147
 None
 1.46A 3n58A-2xtpA:
undetectable		 3n58A-2xtpA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		5 / 10 LEU A 198
GLY A  39
ALA A  38
GLY A  29
VAL A  28
 None
 0.92A 3oxwC-2xtpA:
undetectable		 3oxwC-2xtpA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		5 / 10 TYR A 219
VAL A 129
ILE A 132
LEU A 243
ILE A  75
 None
 1.34A 5hw8C-2xtpA:
undetectable
5hw8H-2xtpA:
undetectable		 5hw8C-2xtpA:
16.80
5hw8H-2xtpA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 7 THR A  58
ASP A  77
ASP A  80
GLY A  34
 None
 1.10A 5hwaA-2xtpA:
undetectable		 5hwaA-2xtpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		6 / 12 ILE A  75
LEU A 101
VAL A  28
PHE A  48
SER A  62
LEU A 144
 None
 1.36A 6b52A-2xtpA:
2.8		 6b52A-2xtpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens) 		4 / 5 GLN A 121
THR A 119
THR A 146
HIS A 147
 None
 1.41A 6gbnB-2xtpA:
3.2		 6gbnB-2xtpA:
20.13