SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xtq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 7 TYR A 188
HIS A 183
LEU A 201
ILE A 263
 None
 0.99A 1tuvA-2xtqA:
undetectable		 1tuvA-2xtqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 7 TYR A 188
HIS A 183
LEU A 201
ILE A 265
 None
 1.10A 1tuvA-2xtqA:
undetectable		 1tuvA-2xtqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 8 TYR A 255
THR A 234
GLY A 193
THR A 192
ALA A 194
 None
 1.45A 2a1hA-2xtqA:
undetectable
2a1hB-2xtqA:
undetectable		 2a1hA-2xtqA:
21.47
2a1hB-2xtqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 6 TYR A 102
TYR A  82
TYR A  18
ILE A 130
 None
 1.29A 2xz5A-2xtqA:
0.0
2xz5B-2xtqA:
undetectable		 2xz5A-2xtqA:
21.58
2xz5B-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 7 TYR A 102
TYR A  82
TYR A  18
ILE A 130
 None
 1.30A 2xz5B-2xtqA:
undetectable
2xz5E-2xtqA:
undetectable		 2xz5B-2xtqA:
21.58
2xz5E-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 8 ILE A 130
TYR A 102
TYR A  82
TYR A  18
 None
 1.28A 2xz5A-2xtqA:
undetectable
2xz5C-2xtqA:
undetectable		 2xz5A-2xtqA:
21.58
2xz5C-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 8 ILE A 130
TYR A 102
TYR A  82
TYR A  18
 None
 1.28A 2xz5C-2xtqA:
undetectable
2xz5D-2xtqA:
undetectable		 2xz5C-2xtqA:
21.58
2xz5D-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 7 ILE A 130
TYR A 102
TYR A  82
TYR A  18
 None
 1.27A 2xz5D-2xtqA:
undetectable
2xz5E-2xtqA:
undetectable		 2xz5D-2xtqA:
21.58
2xz5E-2xtqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 11 THR A 234
VAL A 146
ILE A 257
TYR A 255
THR A 128
 None
 1.42A 3elzB-2xtqA:
3.3		 3elzB-2xtqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 6 ILE A 166
THR A 179
PHE A 181
TYR A 217
 None
 1.28A 3elzB-2xtqA:
3.3		 3elzB-2xtqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2xtq COLICIN-M
(Escherichia
coli) 		4 / 5 ILE A 166
THR A 179
PHE A 181
TYR A 217
 None
 1.35A 3em0A-2xtqA:
3.0		 3em0A-2xtqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 10 ILE A 160
PHE A 181
ILE A 148
ILE A 155
TYR A 217
 None
 1.33A 3um5A-2xtqA:
undetectable		 3um5A-2xtqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 10 ILE A 160
PHE A 181
ILE A 148
ILE A 155
TYR A 217
 None
 1.37A 3um5B-2xtqA:
undetectable		 3um5B-2xtqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 7 TYR A 136
HIS A 235
ILE A 257
ARG A 144
ALA A 132
 None
 1.23A 4lv9A-2xtqA:
undetectable		 4lv9A-2xtqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2xtq COLICIN-M
(Escherichia
coli) 		5 / 9 ILE A 263
THR A 185
LEU A 201
ASN A 147
LEU A 196
 None
 1.40A 5fhzB-2xtqA:
undetectable		 5fhzB-2xtqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2xtq COLICIN-M
(Escherichia
coli) 		3 / 3 ALA A  86
ASN A  89
LEU A  90
 None
 0.49A 5i1nC-2xtqA:
undetectable		 5i1nC-2xtqA:
8.50