SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 11 ILE A 337
GLY A 333
ASN A 411
GLY A 335
ASP A 386
None
1.47A 1ho5A-2xtsA:
undetectable
1ho5A-2xtsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)
2xts CYTOCHROME
(Paracoccus
pantotrophus)
4 / 4 HIS B  74
ALA B  78
PHE B  77
GLY B  80
HEC  B 500 (-3.2A)
None
None
None
1.26A 1mjoA-2xtsB:
undetectable
1mjoA-2xtsB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 10 LEU A 197
ALA A 200
LEU A 139
MET A 130
LEU A 129
None
1.30A 1pcgA-2xtsA:
undetectable
1pcgA-2xtsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 10 LEU A 197
ALA A 200
LEU A 139
MET A 130
LEU A 129
None
1.31A 1pcgB-2xtsA:
undetectable
1pcgB-2xtsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 4 LEU A 324
VAL A 325
ILE A 326
TRP A 373
None
1.45A 1s9qB-2xtsA:
undetectable
1s9qB-2xtsA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)
2xts CYTOCHROME
(Paracoccus
pantotrophus)
6 / 12 ALA B  71
GLY B  75
GLY B  80
ASP B  68
ASP B 133
PRO B 122
None
None
None
None
None
HEC  B 500 (-3.7A)
1.27A 1sqfA-2xtsB:
undetectable
1sqfA-2xtsB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 11 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.90A 2f162-2xtsA:
undetectable
2f162-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 11 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.89A 2f16N-2xtsA:
undetectable
2f16N-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)
2xts SULFITE
DEHYDROGENASE
CYTOCHROME

(Paracoccus
pantotrophus;
Paracoccus
pantotrophus)
5 / 12 ALA B  44
ASP A 274
LYS A 275
GLY A 133
LEU B  46
None
1.24A 2nv4A-2xtsB:
undetectable
2nv4A-2xtsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
2xts SULFITE
DEHYDROGENASE
CYTOCHROME

(Paracoccus
pantotrophus;
Paracoccus
pantotrophus)
4 / 6 THR A 287
THR A 299
ASP B 174
THR B 178
None
CO  A1431 (-3.2A)
None
None
1.11A 2okcB-2xtsA:
undetectable
2okcB-2xtsA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
2xts SULFITE
DEHYDROGENASE
CYTOCHROME

(Paracoccus
pantotrophus;
Paracoccus
pantotrophus)
3 / 3 VAL B 203
ASP B 204
GLU A 425
None
0.47A 2qeuA-2xtsB:
undetectable
2qeuA-2xtsB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
2xts SULFITE
DEHYDROGENASE
CYTOCHROME

(Paracoccus
pantotrophus;
Paracoccus
pantotrophus)
3 / 3 VAL B 203
ASP B 204
GLU A 425
None
0.47A 2qeuC-2xtsB:
undetectable
2qeuC-2xtsB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 GLN A 392
THR A 179
TRP A 416
None
1.07A 2rctA-2xtsA:
undetectable
2rctA-2xtsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 ARG A 354
GLY A 328
HIS A 368
THR A 309
ASN A 185
None
None
None
GOL  A1433 (-3.7A)
None
1.45A 3a25A-2xtsA:
undetectable
3a25A-2xtsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)
2xts SULFITE
DEHYDROGENASE
CYTOCHROME

(Paracoccus
pantotrophus;
Paracoccus
pantotrophus)
5 / 11 GLY B 195
THR B 199
ILE B 198
THR A 415
LEU A 379
None
None
None
GOL  A1432 ( 4.5A)
None
1.20A 3bf1E-2xtsB:
undetectable
3bf1F-2xtsB:
undetectable
3bf1E-2xtsB:
23.05
3bf1F-2xtsB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 GLU A 246
GLU A 113
TRP A 266
None
0.91A 3hrdA-2xtsA:
undetectable
3hrdE-2xtsA:
undetectable
3hrdF-2xtsA:
undetectable
3hrdA-2xtsA:
24.30
3hrdE-2xtsA:
24.30
3hrdF-2xtsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.92A 3mg02-2xtsA:
undetectable
3mg0V-2xtsA:
undetectable
3mg02-2xtsA:
20.94
3mg0V-2xtsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 11 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.90A 3mg0N-2xtsA:
undetectable
3mg0N-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 5 ILE A 413
PRO A 393
LYS A 395
GLY A 412
GOL  A1432 (-4.0A)
None
None
None
1.17A 3tkdB-2xtsA:
undetectable
3tkdB-2xtsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 5 ILE A 413
PRO A 393
LYS A 395
GLY A 412
GOL  A1432 (-4.0A)
None
None
None
1.17A 3tkdA-2xtsA:
undetectable
3tkdA-2xtsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 ASP A 386
GLY A 333
TYR A 390
None
0.79A 3w9tC-2xtsA:
undetectable
3w9tC-2xtsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 ASP A 386
GLY A 333
TYR A 390
None
0.79A 3w9tG-2xtsA:
undetectable
3w9tG-2xtsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)
2xts CYTOCHROME
(Paracoccus
pantotrophus)
4 / 5 THR B 160
GLY B  49
VAL B  45
PRO B  47
None
1.07A 4grkA-2xtsB:
undetectable
4grkA-2xtsB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 GLU A 102
ARG A 366
HIS A 368
GOL  A1433 ( 4.9A)
GOL  A1433 ( 4.9A)
None
0.77A 4kf9A-2xtsA:
undetectable
4kf9A-2xtsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 7 MET A 262
GLU A 259
GLU A 281
GLU A 282
None
CO  A1431 (-2.6A)
None
None
1.25A 4mj8C-2xtsA:
undetectable
4mj8C-2xtsA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
3 / 3 THR A 309
ASN A 185
PHE A 157
GOL  A1433 (-3.7A)
None
None
0.83A 4pd9A-2xtsA:
undetectable
4pd9A-2xtsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.90A 4qvnV-2xtsA:
undetectable
4qvnb-2xtsA:
undetectable
4qvnV-2xtsA:
22.22
4qvnb-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.89A 4qvnH-2xtsA:
undetectable
4qvnN-2xtsA:
undetectable
4qvnH-2xtsA:
22.22
4qvnN-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 10 LEU A 197
ALA A 200
LEU A 139
MET A 130
LEU A 129
None
1.28A 5dxeB-2xtsA:
undetectable
5dxeB-2xtsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 10 LEU A 197
ALA A 200
LEU A 139
MET A 130
LEU A 129
None
1.32A 5hyrA-2xtsA:
undetectable
5hyrA-2xtsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 6 GLY A 164
ASP A 396
ILE A 401
ARG A 402
None
GOL  A1432 (-3.5A)
None
None
1.07A 5iwuA-2xtsA:
undetectable
5iwuA-2xtsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 6 GLY A 165
ASP A 396
ILE A 401
ARG A 402
None
GOL  A1432 (-3.5A)
None
None
1.04A 5iwuA-2xtsA:
undetectable
5iwuA-2xtsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 LEU A 380
ALA A 330
GLY A 328
SER A 327
PRO A 311
None
None
None
GOL  A1433 ( 4.3A)
None
1.31A 5jglA-2xtsA:
undetectable
5jglA-2xtsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 LEU A 380
ALA A 330
GLY A 328
SER A 327
PRO A 311
None
None
None
GOL  A1433 ( 4.3A)
None
1.33A 5jglB-2xtsA:
undetectable
5jglB-2xtsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.95A 5lf7V-2xtsA:
undetectable
5lf7b-2xtsA:
undetectable
5lf7V-2xtsA:
21.47
5lf7b-2xtsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.94A 5lf7H-2xtsA:
undetectable
5lf7N-2xtsA:
undetectable
5lf7H-2xtsA:
21.47
5lf7N-2xtsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)
2xts CYTOCHROME
(Paracoccus
pantotrophus)
4 / 6 THR B  61
ASP B  63
LEU B  65
ASP B  68
None
1.01A 5tdzA-2xtsB:
undetectable
5tdzA-2xtsB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 VAL A 340
ILE A 337
LEU A 329
THR A 365
LEU A 364
None
1.16A 5tiwA-2xtsA:
undetectable
5tiwA-2xtsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
4 / 8 GLY A 320
ILE A 317
LYS A 321
ASP A 374
None
1.00A 6ag0C-2xtsA:
undetectable
6ag0C-2xtsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.88A 6hwdV-2xtsA:
undetectable
6hwdb-2xtsA:
undetectable
6hwdV-2xtsA:
10.99
6hwdb-2xtsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus)
5 / 12 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
None
0.88A 6hwdH-2xtsA:
undetectable
6hwdN-2xtsA:
undetectable
6hwdH-2xtsA:
10.99
6hwdN-2xtsA:
10.93