SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 8 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.66A 1f5lA-2xtzA:
undetectable		 1f5lA-2xtzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 9 LEU A 174
LEU A 167
ILE A  86
THR A 132
ILE A 135
 None
 1.18A 1hzeA-2xtzA:
undetectable
1hzeB-2xtzA:
undetectable		 1hzeA-2xtzA:
14.08
1hzeB-2xtzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 9 THR A 132
ILE A 135
LEU A 174
LEU A 167
ILE A  86
 None
 1.18A 1hzeA-2xtzA:
undetectable
1hzeB-2xtzA:
undetectable		 1hzeA-2xtzA:
14.08
1hzeB-2xtzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 6 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.75A 1tnlA-2xtzA:
undetectable		 1tnlA-2xtzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 9 PHE A 365
VAL A 368
LEU A 372
PHE A  62
LEU A  41
 None
 1.41A 1wrkA-2xtzA:
undetectable
1wrkB-2xtzA:
undetectable		 1wrkA-2xtzA:
13.57
1wrkB-2xtzA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 8 LYS A  59
LYS A 288
THR A 194
GLU A 247
 None
GSP  A1382 (-3.1A)
None
None
 1.48A 1xr2B-2xtzA:
1.7		 1xr2B-2xtzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 7 GLY A 221
SER A  49
ARG A 226
GLU A 247
 GSP  A1382 (-3.4A)
GSP  A1382 (-3.4A)
None
None
 1.05A 2c8aB-2xtzA:
undetectable		 2c8aB-2xtzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 7 GLY A 221
SER A  49
ARG A 226
GLU A 247
 GSP  A1382 (-3.4A)
GSP  A1382 (-3.4A)
None
None
 1.08A 2c8aD-2xtzA:
undetectable		 2c8aD-2xtzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 6 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.73A 2otvA-2xtzA:
undetectable		 2otvA-2xtzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 8 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.70A 2vinA-2xtzA:
undetectable		 2vinA-2xtzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 10 GLU A 325
VAL A 299
PHE A 292
PHE A 289
ARG A 352
 None
 1.31A 3a3yA-2xtzA:
undetectable		 3a3yA-2xtzA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 6 TYR A 106
GLY A 155
THR A  93
GLU A 169
 None
 0.94A 3fpjA-2xtzA:
undetectable		 3fpjA-2xtzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		3 / 3 MET A 168
CYH A 152
PRO A 161
 None
 0.94A 3h52C-2xtzA:
undetectable		 3h52C-2xtzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		4 / 6 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.63A 3rxfA-2xtzA:
undetectable		 3rxfA-2xtzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 12 GLY A  47
VAL A 236
GLY A 220
ASP A 218
GLN A 222
 GSP  A1382 (-3.6A)
None
GSP  A1382 (-3.8A)
MG  A1381 ( 3.8A)
GSP  A1382 ( 4.6A)
 1.20A 5hg0A-2xtzA:
undetectable		 5hg0A-2xtzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 10 TYR A  83
GLY A 123
LEU A 126
ARG A 125
GLU A 121
 None
 1.40A 5hwkA-2xtzA:
undetectable		 5hwkA-2xtzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT
(Arabidopsis
thaliana) 		5 / 10 TYR A  83
GLY A 123
LEU A 126
ARG A 125
GLU A 121
 None
 1.39A 5hwkB-2xtzA:
undetectable		 5hwkB-2xtzA:
22.65