SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 5 TYR A  34
GLU A  27
TYR A 305
PRO A 302
 None
 1.37A 1i7zB-2xu0A:
undetectable		 1i7zB-2xu0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 LYS A 468
ASP A 447
ASP A 444
 None
 1.03A 2br4A-2xu0A:
undetectable		 2br4A-2xu0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ARG A 480
ASP A 340
ASP A 369
 None
 0.89A 2ejtA-2xu0A:
undetectable		 2ejtA-2xu0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 SER A 191
THR A  14
PRO A  13
THR A 304
 None
 0.93A 2v0zO-2xu0A:
undetectable		 2v0zO-2xu0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 7 ARG A 134
GLU A 322
ALA A 131
ALA A 111
 None
 1.12A 2zgwA-2xu0A:
undetectable		 2zgwA-2xu0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 GLY A 243
GLY A 247
GLY A 245
 None
 0.38A 3bogC-2xu0A:
undetectable		 3bogC-2xu0A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ASP A 207
ARG A 119
ARG A 134
 None
 0.93A 3k37A-2xu0A:
undetectable		 3k37A-2xu0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 6 TYR A 426
ASN A 438
LEU A 435
LYS A 431
 None
 1.45A 3lslG-2xu0A:
undetectable		 3lslG-2xu0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 TYR A 274
GLY A 293
ASP A 277
 None
 0.70A 3ou6C-2xu0A:
undetectable		 3ou6C-2xu0A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 PHE A 417
ILE A 402
LEU A  26
PHE A 432
 None
 0.93A 3rqwI-2xu0A:
undetectable
3rqwJ-2xu0A:
undetectable		 3rqwI-2xu0A:
21.07
3rqwJ-2xu0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 GLY A 187
ALA A 186
ASP A 277
GLY A 183
 None
 0.63A 3so9A-2xu0A:
undetectable		 3so9A-2xu0A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ARG A 314
ARG A 204
ASP A 207
 None
 0.72A 3wipG-2xu0A:
undetectable
3wipH-2xu0A:
undetectable		 3wipG-2xu0A:
17.73
3wipH-2xu0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 ALA A 129
LEU A 313
PHE A 316
ILE A 429
LEU A 433
 None
 0.76A 4ej1B-2xu0A:
undetectable		 4ej1B-2xu0A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 7 PHE A 105
ILE A 329
PRO A 177
HIS A 441
 None
 1.10A 4g5jA-2xu0A:
undetectable		 4g5jA-2xu0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 TYR A 305
HIS A 288
ARG A 280
 None
 0.86A 4htfA-2xu0A:
undetectable		 4htfA-2xu0A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 LEU A 433
PHE A 316
TRP A 319
PRO A 457
 None
 1.10A 4j7uD-2xu0A:
undetectable		 4j7uD-2xu0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 10 LEU A 162
ASN A 160
LEU A 146
LEU A 221
VAL A 224
 None
 1.21A 4po0A-2xu0A:
undetectable		 4po0A-2xu0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 ALA A 129
LEU A 313
PHE A 316
ILE A 429
LEU A 433
 None
 0.75A 4x5iA-2xu0A:
undetectable		 4x5iA-2xu0A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 6 LEU A 210
ASN A 212
PRO A 211
ARG A 253
 None
None
GOL  A1491 (-4.8A)
None
 0.95A 4yv5B-2xu0A:
undetectable		 4yv5B-2xu0A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 6 LEU A 210
ASN A 212
PRO A 211
ARG A 253
 None
None
GOL  A1491 (-4.8A)
None
 0.92A 4yv5A-2xu0A:
undetectable		 4yv5A-2xu0A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 ARG A 206
ILE A 202
GLY A 200
ILE A 199
TYR A 308
 None
 1.27A 5ifuA-2xu0A:
undetectable		 5ifuA-2xu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 GLU A 322
PRO A 177
GLY A 187
ASP A 178
 None
 0.90A 5kgpA-2xu0A:
undetectable		 5kgpA-2xu0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 GLU A 322
PRO A 177
GLY A 187
ASP A 178
 None
 0.91A 5kgpB-2xu0A:
undetectable		 5kgpB-2xu0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 7 GLY A 187
ALA A 186
ASP A 277
GLY A 183
 None
 0.66A 5kqyB-2xu0A:
undetectable		 5kqyB-2xu0A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 5 LEU A 157
ARG A 253
LEU A 143
TRP A 256
 None
 1.02A 5m10A-2xu0A:
undetectable		 5m10A-2xu0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 282
SER A 283
LYS A 281
GLU A  27
GLU A 317
 None
 1.23A 5nwuA-2xu0A:
undetectable		 5nwuA-2xu0A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 187
ALA A 186
ASP A 277
GLY A 183
SER A  16
 None
 0.79A 5t2zB-2xu0A:
undetectable		 5t2zB-2xu0A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		5 / 12 ALA A  22
GLY A 439
LEU A 313
ASN A 437
PHE A 432
 None
 1.09A 5ybbA-2xu0A:
undetectable		 5ybbA-2xu0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		3 / 3 ARG A 134
ILE A 172
SER A 191
 None
 0.86A 5zw2A-2xu0A:
2.0		 5zw2A-2xu0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1
(Plasmodium
falciparum) 		4 / 8 ASP A 175
HIS A 441
GLU A 322
GLU A 107
 None
 1.18A 6mn4A-2xu0A:
undetectable		 6mn4A-2xu0A:
18.07