SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 1cqeA-2xu2A:
undetectable		 1cqeA-2xu2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 1cqeB-2xu2A:
undetectable		 1cqeB-2xu2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 232
HIS A  68
LYS A 115
TYR A 121
 CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
CIT  A1249 ( 4.4A)
 1.15A 1eqbA-2xu2A:
undetectable
1eqbB-2xu2A:
undetectable		 1eqbA-2xu2A:
20.95
1eqbB-2xu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 121
HIS A 232
HIS A  68
LYS A 115
 CIT  A1249 ( 4.4A)
CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
 1.16A 1eqbA-2xu2A:
undetectable
1eqbB-2xu2A:
undetectable		 1eqbA-2xu2A:
20.95
1eqbB-2xu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 232
HIS A  68
LYS A 115
TYR A 121
 CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
CIT  A1249 ( 4.4A)
 1.16A 1eqbC-2xu2A:
undetectable
1eqbD-2xu2A:
undetectable		 1eqbC-2xu2A:
20.95
1eqbD-2xu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 121
HIS A 232
HIS A  68
LYS A 115
 CIT  A1249 ( 4.4A)
CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
 1.16A 1eqbC-2xu2A:
undetectable
1eqbD-2xu2A:
undetectable		 1eqbC-2xu2A:
20.95
1eqbD-2xu2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  27
VAL A  55
ILE A  65
GLY A  66
THR A  50
 None
 0.92A 1k6cA-2xu2A:
undetectable		 1k6cA-2xu2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 2aylB-2xu2A:
undetectable		 2aylB-2xu2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 232
HIS A  68
LYS A 115
TYR A 121
 CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
CIT  A1249 ( 4.4A)
 1.21A 2vmyA-2xu2A:
undetectable
2vmyB-2xu2A:
undetectable		 2vmyA-2xu2A:
23.58
2vmyB-2xu2A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 121
HIS A 232
HIS A  68
LYS A 115
 CIT  A1249 ( 4.4A)
CIT  A1249 (-3.7A)
CIT  A1249 (-4.4A)
CIT  A1249 (-2.7A)
 1.16A 2vmyA-2xu2A:
undetectable
2vmyB-2xu2A:
undetectable		 2vmyA-2xu2A:
23.58
2vmyB-2xu2A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  97
ASP A 101
ARG A 142
VAL A 114
PRO A  69
 None
 1.31A 2yzqA-2xu2A:
undetectable		 2yzqA-2xu2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		3 / 3 CYH A  13
PRO A  32
ASP A  26
 None
 0.89A 3hlwB-2xu2A:
undetectable		 3hlwB-2xu2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 3n8wA-2xu2A:
undetectable		 3n8wA-2xu2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 179
ASP A 176
ASP A 234
 None
 0.87A 3ou6B-2xu2A:
undetectable		 3ou6B-2xu2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 229
MET A 148
PHE A 174
ASN A  38
 None
None
CIT  A1249 (-3.9A)
None
 1.42A 3uq6A-2xu2A:
2.4		 3uq6A-2xu2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 137
ALA A  67
ALA A  99
GLY A  98
LEU A 100
 None
 1.10A 4oaeA-2xu2A:
undetectable		 4oaeA-2xu2A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		3 / 3 CYH A  13
PRO A  32
ASP A  26
 None
 0.92A 4pm5A-2xu2A:
undetectable		 4pm5A-2xu2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.01A 4rs0A-2xu2A:
undetectable		 4rs0A-2xu2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 147
TYR A 113
PRO A 116
GLU A 172
 None
 1.15A 4z4gA-2xu2A:
2.8		 4z4gA-2xu2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  65
GLY A  66
PHE A  19
ASP A  14
 None
None
None
CIT  A1249 (-2.9A)
 0.82A 5hieB-2xu2A:
undetectable		 5hieB-2xu2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 8 ILE A  65
GLY A  66
PHE A  19
ASP A  14
 None
None
None
CIT  A1249 (-2.9A)
 0.82A 5hieD-2xu2A:
undetectable		 5hieD-2xu2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 149
LEU A 150
LEU A 169
GLY A 126
LEU A 131
 None
 1.05A 5ikrB-2xu2A:
undetectable		 5ikrB-2xu2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 4 ASP A  14
HIS A  68
HIS A 117
HIS A 232
 CIT  A1249 (-2.9A)
CIT  A1249 (-4.4A)
CIT  A1249 (-3.9A)
CIT  A1249 (-3.7A)
 1.24A 5ncdD-2xu2A:
11.1		 5ncdD-2xu2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		3 / 3 ILE A  97
VAL A 114
PRO A 116
 None
 0.67A 5uunA-2xu2A:
undetectable		 5uunA-2xu2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 147
TYR A 113
LYS A 115
GLU A 172
 None
None
CIT  A1249 (-2.7A)
None
 0.84A 5weaA-2xu2A:
2.2		 5weaA-2xu2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_1
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 4 SER A  30
ASP A 234
HIS A 232
ASP A  27
 None
None
CIT  A1249 (-3.7A)
None
 1.28A 5x7fA-2xu2A:
0.5		 5x7fA-2xu2A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2xu2 UPF0271 PROTEIN
PA4511
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 220
GLY A 192
ALA A 193
LEU A 180
 None
 0.65A 6dwnB-2xu2A:
undetectable		 6dwnB-2xu2A:
18.10