SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 8 GLY A  36
TYR A 186
SER A  34
HIS A 244
 None
 1.11A 1maaD-2xuaA:
12.9		 1maaD-2xuaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 8 GLY A 106
GLY A 103
GLY A 102
MET A 101
LEU A 104
 None
 1.35A 1qzzA-2xuaA:
undetectable		 1qzzA-2xuaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 192
ALA A 196
LEU A 198
LEU A 104
ALA A 108
 None
 1.07A 2bxeA-2xuaA:
undetectable		 2bxeA-2xuaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A 228
ALA A 220
ILE A 129
SER A 100
 None
 1.08A 2othA-2xuaA:
undetectable		 2othA-2xuaA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A 102
ALA A 111
CYH A 123
THR A 125
LEU A 104
 None
 1.40A 2vd0B-2xuaA:
0.0		 2vd0B-2xuaA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 6 THR A 255
VAL A 258
LEU A  49
CYH A  97
 None
 1.06A 3b6rB-2xuaA:
undetectable		 3b6rB-2xuaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		6 / 12 ASP A 217
VAL A 107
GLY A 102
SER A 100
ALA A 126
ALA A 127
 None
 1.48A 3keeB-2xuaA:
undetectable		 3keeB-2xuaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		6 / 12 ASP A 217
VAL A 107
GLY A 102
SER A 100
ALA A 126
ALA A 127
 None
 1.49A 3keeC-2xuaA:
undetectable		 3keeC-2xuaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 11 ARG A  61
LEU A  78
ALA A 196
ASP A 197
ILE A  75
 None
 1.23A 3oxxB-2xuaA:
undetectable		 3oxxB-2xuaA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 7 ILE A  29
VAL A  46
LEU A  49
SER A  50
 None
 0.57A 3r9vA-2xuaA:
undetectable
3r9vB-2xuaA:
undetectable		 3r9vA-2xuaA:
22.15
3r9vB-2xuaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 9 PHE A  53
PHE A 254
ASN A  95
ALA A 121
LEU A  31
 None
 1.42A 3t3sA-2xuaA:
0.0		 3t3sA-2xuaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 7 HIS A 244
LEU A  99
GLY A 214
ALA A 242
 None
 0.99A 3tehB-2xuaA:
undetectable		 3tehB-2xuaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 9 ARG A  61
LEU A  78
ALA A 196
ASP A 197
ILE A  75
 None
 1.31A 3wsjA-2xuaA:
undetectable		 3wsjA-2xuaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 7 ARG A  61
LEU A  78
ALA A 196
ILE A  75
 None
 0.88A 3wsjB-2xuaA:
undetectable		 3wsjB-2xuaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 228
VAL A 211
ALA A 235
GLU A 201
ALA A 202
 None
 1.22A 4fiaA-2xuaA:
undetectable		 4fiaA-2xuaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 228
VAL A 211
ALA A 235
GLU A 201
ALA A 202
 None
 1.22A 4fiaA-2xuaA:
undetectable		 4fiaA-2xuaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 5 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.08A 4w5oA-2xuaA:
3.7		 4w5oA-2xuaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 5 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.10A 4z4cA-2xuaA:
2.0		 4z4cA-2xuaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 5 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.09A 4z4dA-2xuaA:
3.3		 4z4dA-2xuaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 5 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.09A 4z4eA-2xuaA:
3.7		 4z4eA-2xuaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 6 PRO A 208
VAL A 120
ALA A 235
PHE A 261
 None
 1.07A 5t7bA-2xuaA:
4.0		 5t7bA-2xuaA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A  16
ASP A  59
ASP A  38
HIS A  15
 None
 0.90A 6ag0A-2xuaA:
undetectable		 6ag0A-2xuaA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2xua 3-OXOADIPATE
ENOL-LACTONASE
(Paraburkholderia
xenovorans) 		3 / 3 HIS A  65
HIS A  15
ARG A  17
 None
 0.92A 6b58A-2xuaA:
undetectable		 6b58A-2xuaA:
19.57