SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 12 ALA A 431
LEU A 435
MET A 398
LEU A 399
LEU A 370
 None
 0.91A 1errA-2xubA:
undetectable		 1errA-2xubA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 12 ILE A 293
THR A 278
LEU A 288
LEU A 338
ILE A 336
 None
 1.28A 1kqwA-2xubA:
undetectable		 1kqwA-2xubA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.75A 2nmzA-2xubA:
undetectable		 2nmzA-2xubA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.77A 2nnkA-2xubA:
undetectable		 2nnkA-2xubA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		4 / 8 SER A 279
ASP A 240
ARG A 247
ALA A 282
 None
 1.18A 2rk8A-2xubA:
undetectable		 2rk8A-2xubA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		4 / 7 GLY A  44
ASP A  42
ILE A  39
VAL A  50
 None
 0.90A 3fi0E-2xubA:
undetectable		 3fi0E-2xubA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ASP A 318
LEU A 320
GLN A 371
 None
 0.79A 3g4lA-2xubA:
undetectable		 3g4lA-2xubA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.78A 3k4vA-2xubA:
undetectable		 3k4vA-2xubA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.67A 3ndtA-2xubA:
undetectable		 3ndtA-2xubA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.87A 3nduD-2xubA:
undetectable		 3nduD-2xubA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.72A 3pwrA-2xubA:
undetectable		 3pwrA-2xubA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A 150
VAL A 107
THR A  95
 None
 0.79A 3tl9A-2xubA:
undetectable		 3tl9A-2xubA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		3 / 3 ARG A  81
MET A  85
ARG A  84
 None
 1.49A 3uvvA-2xubA:
undetectable		 3uvvA-2xubA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		4 / 4 ASN A 291
GLY A 330
ASP A 318
ASP A 309
 None
 1.18A 4n49A-2xubA:
undetectable		 4n49A-2xubA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		4 / 4 ASN A 291
GLY A 331
ASP A 318
ASP A 309
 None
 1.00A 4n49A-2xubA:
undetectable		 4n49A-2xubA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 12 ALA A 431
LEU A 435
MET A 398
LEU A 399
LEU A 370
 None
 0.89A 4xi3C-2xubA:
undetectable		 4xi3C-2xubA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		4 / 5 TYR A 334
LYS A 325
GLY A 330
SER A 290
 None
 1.02A 5jhdJ-2xubA:
undetectable		 5jhdJ-2xubA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 10 PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
 None
 1.42A 6dlzA-2xubA:
undetectable
6dlzD-2xubA:
5.1		 6dlzA-2xubA:
11.09
6dlzD-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 10 ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
 None
 1.42A 6dlzB-2xubA:
5.1
6dlzC-2xubA:
undetectable		 6dlzB-2xubA:
11.09
6dlzC-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 9 PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
 None
 1.41A 6dm0A-2xubA:
4.2
6dm0D-2xubA:
4.9		 6dm0A-2xubA:
11.09
6dm0D-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 9 ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
 None
 1.42A 6dm0B-2xubA:
4.9
6dm0C-2xubA:
4.3		 6dm0B-2xubA:
11.09
6dm0C-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 10 PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
 None
 1.43A 6dm1A-2xubA:
undetectable
6dm1D-2xubA:
5.1		 6dm1A-2xubA:
11.09
6dm1D-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 10 ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
 None
 1.43A 6dm1B-2xubA:
5.1
6dm1C-2xubA:
undetectable		 6dm1B-2xubA:
11.09
6dm1C-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 9 PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
 None
 1.39A 6dm2A-2xubA:
4.4
6dm2D-2xubA:
5.0		 6dm2A-2xubA:
11.09
6dm2D-2xubA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens) 		5 / 9 ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
 None
 1.39A 6dm2B-2xubA:
4.9
6dm2C-2xubA:
4.4		 6dm2B-2xubA:
11.09
6dm2C-2xubA:
11.09