SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 THR A 468
PRO A 467
THR A 470
 None
 0.97A 1dscC-2xutA:
undetectable		 1dscC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 THR A 470
THR A 468
PRO A 467
 None
 0.83A 1dscC-2xutA:
undetectable		 1dscC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 GLY A  30
LEU A  35
PRO A  37
LEU A 172
ALA A 180
 None
 0.91A 1gseB-2xutA:
undetectable		 1gseB-2xutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 THR A  36
GLN A 341
PHE A  60
ASN A  33
 None
 1.24A 1tt0A-2xutA:
undetectable		 1tt0A-2xutA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 THR A  36
GLN A 341
PHE A  60
ASN A  33
 None
 1.26A 1tt0B-2xutA:
undetectable		 1tt0B-2xutA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 THR A  36
GLN A 341
PHE A  60
ASN A  33
 None
 1.25A 1tt0C-2xutA:
undetectable		 1tt0C-2xutA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 6 THR A  36
GLN A 341
PHE A  60
ASN A  33
 None
 1.24A 1tt0D-2xutA:
undetectable		 1tt0D-2xutA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 LEU A  35
PHE A 181
HIS A  99
GLY A 182
PHE A  63
 None
 1.05A 1zz1B-2xutA:
undetectable
1zz1C-2xutA:
undetectable		 1zz1B-2xutA:
22.16
1zz1C-2xutA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 THR A 470
THR A 468
PRO A 467
 None
 0.87A 209dC-2xutA:
undetectable		 209dC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 LEU A  39
MET A  40
MET A 168
 None
 1.04A 2vavF-2xutA:
undetectable		 2vavF-2xutA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 THR A 468
PRO A 467
THR A 470
 None
 0.81A 316dC-2xutA:
undetectable		 316dC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 8 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.90A 3abkA-2xutA:
2.1
3abkJ-2xutA:
undetectable		 3abkA-2xutA:
23.16
3abkJ-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 8 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.92A 3abmN-2xutA:
1.9
3abmW-2xutA:
undetectable		 3abmN-2xutA:
23.16
3abmW-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 8 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.91A 3asoN-2xutA:
1.4
3asoW-2xutA:
undetectable		 3asoN-2xutA:
23.16
3asoW-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ILE A 119
GLY A  98
ALA A 103
ILE A  94
PRO A 184
 None
 1.10A 3jb1A-2xutA:
undetectable		 3jb1A-2xutA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 7 GLY A 453
SER A 313
PHE A 487
PHE A 488
 None
 0.73A 3v7pA-2xutA:
undetectable		 3v7pA-2xutA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 5 TYR A  29
TRP A 312
PHE A 315
ARG A  32
 None
 1.43A 4g19C-2xutA:
0.0		 4g19C-2xutA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 9 SER A 108
ALA A 103
LEU A 102
GLY A 115
ALA A 342
 None
 1.44A 4l6va-2xutA:
0.0
4l6vf-2xutA:
undetectable		 4l6va-2xutA:
23.43
4l6vf-2xutA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 9 LEU A  43
LEU A 102
SER A 108
THR A 114
VAL A  59
 None
 1.43A 4wnvB-2xutA:
undetectable		 4wnvB-2xutA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 10 ASP A 316
ALA A 120
TYR A  68
PHE A  63
GLY A  66
 None
 1.14A 4xp1A-2xutA:
0.2		 4xp1A-2xutA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 GLY A  66
LEU A 116
LEU A 448
GLY A 125
GLY A  98
 None
 1.12A 5d4uB-2xutA:
undetectable		 5d4uB-2xutA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		3 / 3 ASN A  86
ASP A  79
GLY A  75
 None
 0.60A 5fctB-2xutA:
undetectable		 5fctB-2xutA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		5 / 12 MET A 349
GLY A 160
SER A 161
LEU A 346
PHE A  26
 None
 1.35A 5vlmF-2xutA:
undetectable		 5vlmF-2xutA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN
(Shewanella
oneidensis) 		4 / 8 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.93A 5zcpN-2xutA:
1.9
5zcpW-2xutA:
undetectable		 5zcpN-2xutA:
23.16
5zcpW-2xutA:
8.20