SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 6 PHE A 193
ASN A 194
ARG A 180
GLN A 215
 None
None
EB4  A1300 (-2.8A)
EB4  A1300 (-3.5A)
 1.27A 1t9uA-2xuzA:
undetectable		 1t9uA-2xuzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 TRP A 282
GLY A 279
GLN A 277
PHE A  71
 None
 1.14A 2qx4A-2xuzA:
undetectable
2qx4B-2xuzA:
undetectable		 2qx4A-2xuzA:
21.45
2qx4B-2xuzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 11 LEU A  53
GLY A 142
ILE A 150
GLU A 144
ALA A 147
 None
 1.19A 2yy8A-2xuzA:
2.7
2yy8B-2xuzA:
2.5		 2yy8A-2xuzA:
22.53
2yy8B-2xuzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA A 246
VAL A 269
TRP A 256
GLY A 182
ILE A 179
 None
PEG  A1303 (-4.1A)
None
None
None
 1.44A 3a65A-2xuzA:
undetectable		 3a65A-2xuzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 11 GLY A 118
ALA A 117
LEU A 111
PRO A  87
ILE A  92
 None
 0.90A 3em4U-2xuzA:
undetectable		 3em4U-2xuzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A  49
SER A  46
SER A 103
VAL A 123
 None
None
EB4  A1300 ( 4.4A)
None
 1.06A 3rxhA-2xuzA:
undetectable		 3rxhA-2xuzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 8 ASN A 240
GLY A 182
ALA A 246
ASP A 249
ILE A 177
 None
 1.28A 3so9A-2xuzA:
undetectable		 3so9A-2xuzA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 LEU A 101
VAL A  31
TYR A  24
TYR A  29
 None
 1.15A 4b3qA-2xuzA:
undetectable		 4b3qA-2xuzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 5 VAL A 285
ARG A 286
GLU A  48
LEU A  52
 None
 1.45A 4hojA-2xuzA:
undetectable		 4hojA-2xuzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 LYS A 105
ARG A 178
GLN A 277
GLU A  45
 EB4  A1300 ( 2.9A)
EB4  A1300 (-4.1A)
None
None
 1.26A 4mv7A-2xuzA:
5.5		 4mv7A-2xuzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 VAL A  44
ALA A 276
PHE A  71
 None
 0.93A 4olbA-2xuzA:
5.0		 4olbA-2xuzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 8 PHE A  67
PHE A  63
GLY A  82
ILE A  92
 PG4  A1302 (-3.7A)
None
None
None
 0.93A 4qogA-2xuzA:
3.5
4qogB-2xuzA:
2.2		 4qogA-2xuzA:
21.69
4qogB-2xuzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 ASP A  54
HIS A  56
LYS A  51
 None
 0.86A 4qzuD-2xuzA:
undetectable		 4qzuD-2xuzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 VAL A  44
ALA A 276
PHE A  71
 None
 0.93A 4z4iA-2xuzA:
3.4		 4z4iA-2xuzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 5 PRO A 274
ALA A 276
LYS A  84
GLN A 277
 None
None
EB4  A1300 ( 2.5A)
None
 1.20A 5odcA-2xuzA:
4.4
5odcG-2xuzA:
3.6		 5odcA-2xuzA:
18.50
5odcG-2xuzA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 8 ILE A 121
LEU A 140
LEU A  53
ALA A  50
 None
 0.74A 5y7pE-2xuzA:
undetectable		 5y7pE-2xuzA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 LEU A 288
ALA A 291
ALA A 292
THR A 296
 None
 0.62A 6a7jA-2xuzA:
undetectable		 6a7jA-2xuzA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 10 ALA A  60
PHE A  63
MET A  70
VAL A  44
THR A  81
 None
 1.46A 6aogA-2xuzA:
undetectable		 6aogA-2xuzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		5 / 10 ALA A  60
PHE A  63
MET A  70
VAL A  44
THR A  81
 None
 1.44A 6aogB-2xuzA:
undetectable		 6aogB-2xuzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 THR A 161
ALA A 292
LYS A 294
 None
None
PEG  A1303 ( 3.7A)
 0.72A 6fgcA-2xuzA:
4.2		 6fgcA-2xuzA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		3 / 3 THR A 161
ALA A 292
LYS A 294
 None
None
PEG  A1303 ( 3.7A)
 0.66A 6fgdA-2xuzA:
3.6		 6fgdA-2xuzA:
22.79