SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
LEU A 105
ILE A  99
LEU A 100
PHE A  92
 SFG  A1198 (-4.3A)
None
None
None
None
 0.94A 1mx1D-2xvaA:
undetectable		 1mx1D-2xvaA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		3 / 3 PRO A  31
ASP A  97
ASP A  54
 None
 0.64A 1sqfA-2xvaA:
11.5		 1sqfA-2xvaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 7 GLY A  40
ASP A  59
ASP A  86
LEU A  87
 SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
 0.49A 2uyqA-2xvaA:
13.4		 2uyqA-2xvaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 LEU A  37
GLY A  38
GLY A  40
LEU A  87
LEU A  90
 None
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.8A)
None
 0.81A 2zbpA-2xvaA:
14.2		 2zbpA-2xvaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  86
LEU A  87
ASN A  88
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
SFG  A1198 (-4.0A)
 0.51A 2zw9B-2xvaA:
12.3		 2zw9B-2xvaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 ASP A  36
LEU A  37
GLY A  38
ASP A  59
LEU A 108
 SFG  A1198 ( 4.7A)
None
SFG  A1198 (-4.3A)
SFG  A1198 (-2.8A)
SFG  A1198 (-4.8A)
 0.92A 3cjtC-2xvaA:
14.7		 3cjtC-2xvaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.19A 3erdA-2xvaA:
undetectable		 3erdA-2xvaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.13A 3hm1A-2xvaA:
undetectable		 3hm1A-2xvaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 6 VAL A  22
LEU A  87
ILE A  65
LEU A 100
 None
SFG  A1198 (-3.8A)
None
None
 0.93A 3kk6A-2xvaA:
undetectable		 3kk6A-2xvaA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  86
LEU A  87
VAL A 104
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
SFG  A1198 (-3.8A)
 0.41A 3o7wA-2xvaA:
11.2		 3o7wA-2xvaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		3 / 3 GLY A  40
ASP A  59
ASP A  86
 SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
SFG  A1198 (-3.9A)
 0.16A 3ou7C-2xvaA:
15.1		 3ou7C-2xvaA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASN A  44
LYS A  60
ASP A  86
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.3A)
SFG  A1198 (-3.9A)
 0.78A 3sglA-2xvaA:
9.7		 3sglA-2xvaA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 5 ILE A  74
ASP A  78
GLU A  75
VAL A  68
 None
 1.05A 4nkxC-2xvaA:
undetectable		 4nkxC-2xvaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 11 LEU A  23
ALA A  25
LEU A 100
LEU A 131
LEU A  48
 None
 1.17A 4zn7B-2xvaA:
undetectable		 4zn7B-2xvaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 7 ASN A  79
VAL A  55
ALA A  57
GLY A  42
 None
 0.86A 5fpdB-2xvaA:
undetectable		 5fpdB-2xvaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		3 / 3 MET A 192
GLU A 161
ARG A 165
 None
 1.13A 5tjyA-2xvaA:
4.4		 5tjyA-2xvaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  59
ASN A  61
LEU A 108
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
None
SFG  A1198 (-4.8A)
 0.52A 5wy0A-2xvaA:
14.0		 5wy0A-2xvaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 6 GLU A  21
LYS A 167
LEU A 193
LEU A 131
 None
 0.87A 5yvnA-2xvaA:
undetectable		 5yvnA-2xvaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 ASP A  36
GLY A  38
GLY A  40
LYS A  60
ASP A  86
 SFG  A1198 ( 4.7A)
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.3A)
SFG  A1198 (-3.9A)
 0.63A 6nj9K-2xvaA:
11.8		 6nj9K-2xvaA:
20.43