SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2xvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		3 / 3 PRO A 363
ASP A 361
ASP A 359
 None
 0.79A 1sqfA-2xvsA:
undetectable		 1sqfA-2xvsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.11A 2y69C-2xvsA:
undetectable
2y69J-2xvsA:
undetectable		 2y69C-2xvsA:
19.25
2y69J-2xvsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.14A 2y69P-2xvsA:
undetectable
2y69W-2xvsA:
undetectable		 2y69P-2xvsA:
19.25
2y69W-2xvsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.12A 3abmC-2xvsA:
undetectable
3abmJ-2xvsA:
undetectable		 3abmC-2xvsA:
19.25
3abmJ-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.16A 3abmP-2xvsA:
undetectable
3abmW-2xvsA:
undetectable		 3abmP-2xvsA:
19.25
3abmW-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.14A 3ag3C-2xvsA:
undetectable
3ag3J-2xvsA:
undetectable		 3ag3C-2xvsA:
19.25
3ag3J-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 296
GLY A 381
GLY A 339
SER A 383
ASP A 359
 None
 1.26A 3ou7A-2xvsA:
undetectable		 3ou7A-2xvsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A 391
VAL A 367
TYR A 365
LEU A 393
 None
 0.94A 3v81A-2xvsA:
undetectable		 3v81A-2xvsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		5 / 11 ASN A 390
VAL A 331
ILE A 337
TYR A 309
ALA A 335
 None
 1.46A 4m83B-2xvsA:
undetectable		 4m83B-2xvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A 391
VAL A 367
TYR A 365
LEU A 393
 None
 0.93A 4pwdA-2xvsA:
undetectable		 4pwdA-2xvsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.15A 5wauC-2xvsA:
undetectable
5wauJ-2xvsA:
undetectable		 5wauC-2xvsA:
19.25
5wauJ-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.14A 5wauc-2xvsA:
undetectable
5wauj-2xvsA:
undetectable		 5wauc-2xvsA:
19.25
5wauj-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.11A 5xdqC-2xvsA:
undetectable
5xdqJ-2xvsA:
undetectable		 5xdqC-2xvsA:
19.25
5xdqJ-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.13A 5xdqP-2xvsA:
undetectable
5xdqW-2xvsA:
undetectable		 5xdqP-2xvsA:
19.25
5xdqW-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 6 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.12A 5z86C-2xvsA:
undetectable
5z86J-2xvsA:
undetectable		 5z86C-2xvsA:
19.25
5z86J-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 6 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.12A 5zcoP-2xvsA:
undetectable
5zcoW-2xvsA:
undetectable		 5zcoP-2xvsA:
19.25
5zcoW-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5
(Homo
sapiens) 		4 / 6 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.10A 5zcpC-2xvsA:
undetectable
5zcpJ-2xvsA:
undetectable		 5zcpC-2xvsA:
19.25
5zcpJ-2xvsA:
21.97